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Protein

DNA-directed RNA polymerase III subunit RPC3

Gene

Polr3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-RNO-1834949. Cytosolic sensors of pathogen-associated DNA.
R-RNO-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-RNO-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-RNO-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC3
Short name:
RNA polymerase III subunit C3
Alternative name(s):
DNA-directed RNA polymerase III subunit C
Gene namesi
Name:Polr3c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311545. Polr3c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533DNA-directed RNA polymerase III subunit RPC3PRO_0000254906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIL3.
PRIDEiQ5XIL3.

Expressioni

Gene expression databases

GenevisibleiQ5XIL3. RN.

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028815.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2587. Eukaryota.
ENOG410XPVH. LUCA.
GeneTreeiENSGT00390000002799.
HOGENOMiHOG000046475.
HOVERGENiHBG059543.
InParanoidiQ5XIL3.
KOiK03023.
OMAiNQLPTAR.
OrthoDBiEOG7TMZS8.
PhylomeDBiQ5XIL3.
TreeFamiTF103048.

Family and domain databases

InterProiIPR013197. RNA_pol_III_RPC82-rel_HTH.
IPR008806. RNA_pol_III_Rpc82_C.
[Graphical view]
PfamiPF08221. HTH_9. 1 hit.
PF05645. RNA_pol_Rpc82. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTKASLDQV
60 70 80 90 100
KKALCVLIHH NLVIYHVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYG
110 120 130 140 150
DTGELIVEEL LLNGKMTMSA VVKKVADRLT ETMEDGKTMD YAEVSNAFVR
160 170 180 190 200
LADTHFVQRC PLVPDTDSSD PGPPPPAPNL VINEKDMYLV PKLSLIGKGK
210 220 230 240 250
RRRSSDEDAA GEPKAKKPRC TDNEEPTPDD GIYWQVNLDR FHQHFRDQAI
260 270 280 290 300
VSAVANRMDQ TSSEIVRTML RMSEITTPSG APFTQPLSSN EIFRSLPVGY
310 320 330 340 350
NISKQVLDQY LTLLADDPLE FIGKAGDSGG GMYVINLHKA LASLSTATLE
360 370 380 390 400
SVIQERFGSR CARIFRLVLQ KKHLEQKQVE DFAMIPAKEA KDMLYKMLSE
410 420 430 440 450
NFISLQEIPK TPDHAPSRTF YLYTVNVLSA ARMLLHRCYK SIANLIERRQ
460 470 480 490 500
FETKENKRLL EKSQRVEAIM ASMQATGAEE VQLQEIEEMI TAPERQQLET
510 520 530
LKRNVNKLDA SEIQVDETIF LLESYIESTM KRQ
Length:533
Mass (Da):60,543
Last modified:November 23, 2004 - v1
Checksum:i6584FD72D4962312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083667 mRNA. Translation: AAH83667.1.
RefSeqiNP_001012081.1. NM_001012081.1.
XP_008759532.1. XM_008761310.1.
UniGeneiRn.35251.

Genome annotation databases

EnsembliENSRNOT00000028815; ENSRNOP00000028815; ENSRNOG00000033560.
GeneIDi310685.
KEGGirno:310685.
UCSCiRGD:1311545. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083667 mRNA. Translation: AAH83667.1.
RefSeqiNP_001012081.1. NM_001012081.1.
XP_008759532.1. XM_008761310.1.
UniGeneiRn.35251.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028815.

Proteomic databases

PaxDbiQ5XIL3.
PRIDEiQ5XIL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028815; ENSRNOP00000028815; ENSRNOG00000033560.
GeneIDi310685.
KEGGirno:310685.
UCSCiRGD:1311545. rat.

Organism-specific databases

CTDi10623.
RGDi1311545. Polr3c.

Phylogenomic databases

eggNOGiKOG2587. Eukaryota.
ENOG410XPVH. LUCA.
GeneTreeiENSGT00390000002799.
HOGENOMiHOG000046475.
HOVERGENiHBG059543.
InParanoidiQ5XIL3.
KOiK03023.
OMAiNQLPTAR.
OrthoDBiEOG7TMZS8.
PhylomeDBiQ5XIL3.
TreeFamiTF103048.

Enzyme and pathway databases

ReactomeiR-RNO-1834949. Cytosolic sensors of pathogen-associated DNA.
R-RNO-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-RNO-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-RNO-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

NextBioi662443.
PROiQ5XIL3.

Gene expression databases

GenevisibleiQ5XIL3. RN.

Family and domain databases

InterProiIPR013197. RNA_pol_III_RPC82-rel_HTH.
IPR008806. RNA_pol_III_Rpc82_C.
[Graphical view]
PfamiPF08221. HTH_9. 1 hit.
PF05645. RNA_pol_Rpc82. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiRPC3_RAT
AccessioniPrimary (citable) accession number: Q5XIL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.