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Protein

Katanin p60 ATPase-containing subunit A-like 1

Gene

Katnal1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 253ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A-like 1UniRule annotation (EC:3.6.4.3UniRule annotation)
Short name:
Katanin p60 subunit A-like 1UniRule annotation
Alternative name(s):
p60 katanin-like 1UniRule annotation
Gene namesi
Name:Katnal1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1359252. Katnal1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846031 – 488Katanin p60 ATPase-containing subunit A-like 1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei172PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XIK7.
PRIDEiQ5XIK7.

PTM databases

iPTMnetiQ5XIK7.
PhosphoSitePlusiQ5XIK7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000916.
ExpressionAtlasiQ5XIK7. baseline.
GenevisibleiQ5XIK7. RN.

Interactioni

Subunit structurei

Interacts with KATNB1 and KATNBL1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065936.

Structurei

3D structure databases

ProteinModelPortaliQ5XIK7.
SMRiQ5XIK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0738. Eukaryota.
ENOG410XPN7. LUCA.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ5XIK7.
KOiK07767.
OMAiDKGRKNM.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ5XIK7.
TreeFamiTF323170.

Family and domain databases

HAMAPiMF_03023. Katanin_p60_A1. 1 hit.
MF_03024. Katanin_p60_AL1. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR028594. Katnal1_chordates.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XIK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAEICENA KKGREYALLG NYDSSMVYYQ GVIQQIQRHC QSLRDPATKA
60 70 80 90 100
KWQQVRQELL EEYEQVKSIV STLESFKMDK PPDFPVSCRD EPFRDPAVWP
110 120 130 140 150
PPVPAEHRAP PQIRRPNREV RPLRKDMGAG ARGLVGRAHQ ISKSDKAASR
160 170 180 190 200
DKDYRARGRD DKARKNMQDG ASDGEIPKFD GAGYDKDLVE ALERDIVSRN
210 220 230 240 250
PSIHWDDIAD LEEAKKLLRE AVVLPMWMPD FFKGIRRPWK GVLMVGPPGT
260 270 280 290 300
GKTMLAKAVA TECGTTFFNV SSSTLTSKYR GESEKLVRLL FEMARFYAPT
310 320 330 340 350
TIFIDEIDSI CSRRGTSDEH EASRRVKSEL LIQMDGVGGA LENDDPSKMV
360 370 380 390 400
MVLAATNFPW DIDEALRRRL EKRIYIPLPT AKGRAELLKI SLREVELDPD
410 420 430 440 450
IHLEDIAEKT EGYSGADITN ICRDASLMAM RRRINGLSPE EIRALSKEEL
460 470 480
QMPVTRGDLE LALKKIAKSV SAADLEKYEK WMVEFGSA
Length:488
Mass (Da):55,201
Last modified:November 23, 2004 - v1
Checksum:i0ED5B66744EEBCD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083673 mRNA. Translation: AAH83673.1.
RefSeqiNP_001006957.1. NM_001006956.1.
XP_003751164.1. XM_003751116.4.
XP_006248878.1. XM_006248816.3.
XP_006248879.1. XM_006248817.3.
XP_006248886.1. XM_006248824.3.
XP_017453776.1. XM_017598287.1.
XP_017453970.1. XM_017598481.1.
XP_017453971.1. XM_017598482.1.
XP_017459908.1. XM_017604419.1.
XP_017459909.1. XM_017604420.1.
XP_017459910.1. XM_017604421.1.
XP_017459911.1. XM_017604422.1.
XP_017459912.1. XM_017604423.1.
UniGeneiRn.208215.

Genome annotation databases

EnsembliENSRNOT00000001219; ENSRNOP00000001219; ENSRNOG00000000916.
ENSRNOT00000072801; ENSRNOP00000065936; ENSRNOG00000047618.
ENSRNOT00000077328; ENSRNOP00000068753; ENSRNOG00000047618.
GeneIDi100910196.
103690050.
288449.
KEGGirno:100910196.
rno:103690050.
rno:288449.
UCSCiRGD:1359252. rat.

Similar proteinsi

Entry informationi

Entry nameiKATL1_RAT
AccessioniPrimary (citable) accession number: Q5XIK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families