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Q5XIK2

- TMX2_RAT

UniProt

Q5XIK2 - TMX2_RAT

Protein

Thioredoxin-related transmembrane protein 2

Gene

Tmx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin-related transmembrane protein 2
    Alternative name(s):
    Thioredoxin domain-containing protein 14
    Gene namesi
    Name:Tmx2
    Synonyms:Txndc14
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1359456. Tmx2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4848Sequence AnalysisAdd
    BLAST
    Chaini49 – 295247Thioredoxin-related transmembrane protein 2PRO_0000315756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei243 – 2431PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5XIK2.
    PRIDEiQ5XIK2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XIK2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XIK2.
    SMRiQ5XIK2. Positions 137-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini49 – 10254ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 295170CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei103 – 12523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 269156ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi292 – 2954Di-lysine motif

    Domaini

    The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.By similarity
    The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

    Sequence similaritiesi

    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256458.
    GeneTreeiENSGT00390000003751.
    HOGENOMiHOG000007149.
    InParanoidiQ5XIK2.
    OMAiSKAGDNI.
    OrthoDBiEOG718KCN.
    PhylomeDBiQ5XIK2.
    TreeFamiTF314606.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5XIK2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLAPLIAL VYSVPRLSRW LARPYCLLSA LLSIAFLLVR KLPPICNGLP    50
    TQREDGNPCD FDWREVEILM FLSAIVMMKN RRSITVEQHV GNIFMFSKVA 100
    NAILFFRLDI RMGLLYLTLC IVFLMTCKPP LYMGPEYIKY FNDKTIDEEL 150
    ERDKRVTWIV EFFANWSNDC QSFAPIYADL SLKYNCSGLN FGKVDVGRYT 200
    DVSTRYKVST SPLTKQLPTL ILFQGGKEVM RRPQIDKKGR AVSWTFSEEN 250
    VIREFNLNEL YQRAKKLSKG GDMSEEKPGN PTPTAVPDGE NKKDK 295
    Length:295
    Mass (Da):33,866
    Last modified:November 23, 2004 - v1
    Checksum:iC64BA65CDC600B34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083678 mRNA. Translation: AAH83678.1.
    RefSeqiNP_001007644.1. NM_001007643.1.
    UniGeneiRn.3027.

    Genome annotation databases

    EnsembliENSRNOT00000007914; ENSRNOP00000007914; ENSRNOG00000005308.
    GeneIDi295701.
    KEGGirno:295701.
    UCSCiRGD:1359456. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083678 mRNA. Translation: AAH83678.1 .
    RefSeqi NP_001007644.1. NM_001007643.1.
    UniGenei Rn.3027.

    3D structure databases

    ProteinModelPortali Q5XIK2.
    SMRi Q5XIK2. Positions 137-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007914.

    Proteomic databases

    PaxDbi Q5XIK2.
    PRIDEi Q5XIK2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007914 ; ENSRNOP00000007914 ; ENSRNOG00000005308 .
    GeneIDi 295701.
    KEGGi rno:295701.
    UCSCi RGD:1359456. rat.

    Organism-specific databases

    CTDi 51075.
    RGDi 1359456. Tmx2.

    Phylogenomic databases

    eggNOGi NOG256458.
    GeneTreei ENSGT00390000003751.
    HOGENOMi HOG000007149.
    InParanoidi Q5XIK2.
    OMAi SKAGDNI.
    OrthoDBi EOG718KCN.
    PhylomeDBi Q5XIK2.
    TreeFami TF314606.

    Miscellaneous databases

    NextBioi 639918.
    PROi Q5XIK2.

    Gene expression databases

    Genevestigatori Q5XIK2.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiTMX2_RAT
    AccessioniPrimary (citable) accession number: Q5XIK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3