Q5XIK2 (TMX2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin-related transmembrane protein 2

Alternative name(s):
Thioredoxin domain-containing protein 14

Gene names

Name:	Tmx2
Synonyms:	Txndc14

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Domain	The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity By similarity. The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins By similarity.
Sequence similarities	Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 48	48	Potential
	Chain	49 – 295	247	Thioredoxin-related transmembrane protein 2		PRO_0000315756
Regions
	Topological domain	49 – 102	54	Extracellular Potential
	Transmembrane	103 – 125	23	Helical; Potential
	Topological domain	126 – 295	170	Cytoplasmic Potential
	Domain	114 – 269	156	Thioredoxin
	Motif	292 – 295	4	Di-lysine motif
Amino acid modifications
	Modified residue	243	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5XIK2 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: C64BA65CDC600B34	FASTA	295	33,866
	10 20 30 40 50 60 MAVLAPLIAL VYSVPRLSRW LARPYCLLSA LLSIAFLLVR KLPPICNGLP TQREDGNPCD 70 80 90 100 110 120 FDWREVEILM FLSAIVMMKN RRSITVEQHV GNIFMFSKVA NAILFFRLDI RMGLLYLTLC 130 140 150 160 170 180 IVFLMTCKPP LYMGPEYIKY FNDKTIDEEL ERDKRVTWIV EFFANWSNDC QSFAPIYADL 190 200 210 220 230 240 SLKYNCSGLN FGKVDVGRYT DVSTRYKVST SPLTKQLPTL ILFQGGKEVM RRPQIDKKGR 250 260 270 280 290 AVSWTFSEEN VIREFNLNEL YQRAKKLSKG GDMSEEKPGN PTPTAVPDGE NKKDK

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC083678 mRNA. Translation: AAH83678.1.
IPI	IPI00188819.
RefSeq	NP_001007644.1. NM_001007643.1.
UniGene	Rn.3027.
3D structure databases
ProteinModelPortal	Q5XIK2.
SMR	Q5XIK2. Positions 137-260.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000007914.
Proteomic databases
PaxDb	Q5XIK2.
PRIDE	Q5XIK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000007914; ENSRNOP00000007914; ENSRNOG00000005308.
GeneID	295701.
KEGG	rno:295701.
UCSC	RGD:1359456. rat.
Organism-specific databases
CTD	51075.
RGD	1359456. Tmx2.
Phylogenomic databases
eggNOG	NOG256458.
GeneTree	ENSGT00390000003751.
HOGENOM	HOG000007149.
InParanoid	Q5XIK2.
OMA	VEQHVGN.
OrthoDB	EOG47SSF8.
Gene expression databases
Genevestigator	Q5XIK2.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR012336. Thioredoxin-like_fold. IPR013766. Thioredoxin_domain. [Graphical view]
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. False negative. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	639918.

Entry information

Entry name

TMX2_RAT

Accession

Primary (citable) accession number: Q5XIK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program