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Protein

Thioredoxin-related transmembrane protein 2

Gene

Tmx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 2
Alternative name(s):
Thioredoxin domain-containing protein 14
Gene namesi
Name:Tmx2
Synonyms:Txndc14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1359456. Tmx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini49 – 10254ExtracellularSequence AnalysisAdd
BLAST
Transmembranei103 – 12523HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 295170CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4848Sequence AnalysisAdd
BLAST
Chaini49 – 295247Thioredoxin-related transmembrane protein 2PRO_0000315756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIK2.
PRIDEiQ5XIK2.

Expressioni

Gene expression databases

GenevestigatoriQ5XIK2.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007914.

Structurei

3D structure databases

ProteinModelPortaliQ5XIK2.
SMRiQ5XIK2. Positions 137-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 269156ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi292 – 2954Di-lysine motif

Domaini

The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.By similarity
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256458.
GeneTreeiENSGT00390000003751.
HOGENOMiHOG000007149.
InParanoidiQ5XIK2.
OMAiKYNCTGL.
OrthoDBiEOG718KCN.
PhylomeDBiQ5XIK2.
TreeFamiTF314606.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLAPLIAL VYSVPRLSRW LARPYCLLSA LLSIAFLLVR KLPPICNGLP
60 70 80 90 100
TQREDGNPCD FDWREVEILM FLSAIVMMKN RRSITVEQHV GNIFMFSKVA
110 120 130 140 150
NAILFFRLDI RMGLLYLTLC IVFLMTCKPP LYMGPEYIKY FNDKTIDEEL
160 170 180 190 200
ERDKRVTWIV EFFANWSNDC QSFAPIYADL SLKYNCSGLN FGKVDVGRYT
210 220 230 240 250
DVSTRYKVST SPLTKQLPTL ILFQGGKEVM RRPQIDKKGR AVSWTFSEEN
260 270 280 290
VIREFNLNEL YQRAKKLSKG GDMSEEKPGN PTPTAVPDGE NKKDK
Length:295
Mass (Da):33,866
Last modified:November 23, 2004 - v1
Checksum:iC64BA65CDC600B34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083678 mRNA. Translation: AAH83678.1.
RefSeqiNP_001007644.1. NM_001007643.1.
UniGeneiRn.3027.

Genome annotation databases

EnsembliENSRNOT00000007914; ENSRNOP00000007914; ENSRNOG00000005308.
GeneIDi295701.
KEGGirno:295701.
UCSCiRGD:1359456. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083678 mRNA. Translation: AAH83678.1.
RefSeqiNP_001007644.1. NM_001007643.1.
UniGeneiRn.3027.

3D structure databases

ProteinModelPortaliQ5XIK2.
SMRiQ5XIK2. Positions 137-260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007914.

Proteomic databases

PaxDbiQ5XIK2.
PRIDEiQ5XIK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007914; ENSRNOP00000007914; ENSRNOG00000005308.
GeneIDi295701.
KEGGirno:295701.
UCSCiRGD:1359456. rat.

Organism-specific databases

CTDi51075.
RGDi1359456. Tmx2.

Phylogenomic databases

eggNOGiNOG256458.
GeneTreeiENSGT00390000003751.
HOGENOMiHOG000007149.
InParanoidiQ5XIK2.
OMAiKYNCTGL.
OrthoDBiEOG718KCN.
PhylomeDBiQ5XIK2.
TreeFamiTF314606.

Miscellaneous databases

NextBioi639918.
PROiQ5XIK2.

Gene expression databases

GenevestigatoriQ5XIK2.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTMX2_RAT
AccessioniPrimary (citable) accession number: Q5XIK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: March 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.