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Q5XIK2 (TMX2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin-related transmembrane protein 2
Alternative name(s):
Thioredoxin domain-containing protein 14
Gene names
Name:Tmx2
Synonyms:Txndc14
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Domain

The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity By similarity.

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins By similarity.

Sequence similarities

Contains 1 thioredoxin domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4848 Potential
Chain49 – 295247Thioredoxin-related transmembrane protein 2
PRO_0000315756

Regions

Topological domain49 – 10254Extracellular Potential
Transmembrane103 – 12523Helical; Potential
Topological domain126 – 295170Cytoplasmic Potential
Domain114 – 269156Thioredoxin
Motif292 – 2954Di-lysine motif

Amino acid modifications

Modified residue2431Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XIK2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C64BA65CDC600B34

FASTA29533,866
        10         20         30         40         50         60 
MAVLAPLIAL VYSVPRLSRW LARPYCLLSA LLSIAFLLVR KLPPICNGLP TQREDGNPCD 

        70         80         90        100        110        120 
FDWREVEILM FLSAIVMMKN RRSITVEQHV GNIFMFSKVA NAILFFRLDI RMGLLYLTLC 

       130        140        150        160        170        180 
IVFLMTCKPP LYMGPEYIKY FNDKTIDEEL ERDKRVTWIV EFFANWSNDC QSFAPIYADL 

       190        200        210        220        230        240 
SLKYNCSGLN FGKVDVGRYT DVSTRYKVST SPLTKQLPTL ILFQGGKEVM RRPQIDKKGR 

       250        260        270        280        290 
AVSWTFSEEN VIREFNLNEL YQRAKKLSKG GDMSEEKPGN PTPTAVPDGE NKKDK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC083678 mRNA. Translation: AAH83678.1.
RefSeqNP_001007644.1. NM_001007643.1.
UniGeneRn.3027.

3D structure databases

ProteinModelPortalQ5XIK2.
SMRQ5XIK2. Positions 137-260.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007914.

Proteomic databases

PaxDbQ5XIK2.
PRIDEQ5XIK2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007914; ENSRNOP00000007914; ENSRNOG00000005308.
GeneID295701.
KEGGrno:295701.
UCSCRGD:1359456. rat.

Organism-specific databases

CTD51075.
RGD1359456. Tmx2.

Phylogenomic databases

eggNOGNOG256458.
GeneTreeENSGT00390000003751.
HOGENOMHOG000007149.
InParanoidQ5XIK2.
OMAKYNCTGL.
OrthoDBEOG718KCN.
PhylomeDBQ5XIK2.
TreeFamTF314606.

Gene expression databases

GenevestigatorQ5XIK2.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio639918.
PROQ5XIK2.

Entry information

Entry nameTMX2_RAT
AccessionPrimary (citable) accession number: Q5XIK2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families