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Q5XIK2

- TMX2_RAT

UniProt

Q5XIK2 - TMX2_RAT

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Protein
Thioredoxin-related transmembrane protein 2
Gene
Tmx2, Txndc14
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 2
Alternative name(s):
Thioredoxin domain-containing protein 14
Gene namesi
Name:Tmx2
Synonyms:Txndc14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1359456. Tmx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini49 – 10254Extracellular Reviewed prediction
Add
BLAST
Transmembranei103 – 12523Helical; Reviewed prediction
Add
BLAST
Topological domaini126 – 295170Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4848 Reviewed prediction
Add
BLAST
Chaini49 – 295247Thioredoxin-related transmembrane protein 2
PRO_0000315756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIK2.
PRIDEiQ5XIK2.

Expressioni

Gene expression databases

GenevestigatoriQ5XIK2.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007914.

Structurei

3D structure databases

ProteinModelPortaliQ5XIK2.
SMRiQ5XIK2. Positions 137-260.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 269156Thioredoxin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi292 – 2954Di-lysine motif

Domaini

The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity By similarity.
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins By similarity.

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256458.
GeneTreeiENSGT00390000003751.
HOGENOMiHOG000007149.
InParanoidiQ5XIK2.
OMAiSKAGDNI.
OrthoDBiEOG718KCN.
PhylomeDBiQ5XIK2.
TreeFamiTF314606.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIK2-1 [UniParc]FASTAAdd to Basket

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MAVLAPLIAL VYSVPRLSRW LARPYCLLSA LLSIAFLLVR KLPPICNGLP    50
TQREDGNPCD FDWREVEILM FLSAIVMMKN RRSITVEQHV GNIFMFSKVA 100
NAILFFRLDI RMGLLYLTLC IVFLMTCKPP LYMGPEYIKY FNDKTIDEEL 150
ERDKRVTWIV EFFANWSNDC QSFAPIYADL SLKYNCSGLN FGKVDVGRYT 200
DVSTRYKVST SPLTKQLPTL ILFQGGKEVM RRPQIDKKGR AVSWTFSEEN 250
VIREFNLNEL YQRAKKLSKG GDMSEEKPGN PTPTAVPDGE NKKDK 295
Length:295
Mass (Da):33,866
Last modified:November 23, 2004 - v1
Checksum:iC64BA65CDC600B34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC083678 mRNA. Translation: AAH83678.1.
RefSeqiNP_001007644.1. NM_001007643.1.
UniGeneiRn.3027.

Genome annotation databases

EnsembliENSRNOT00000007914; ENSRNOP00000007914; ENSRNOG00000005308.
GeneIDi295701.
KEGGirno:295701.
UCSCiRGD:1359456. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC083678 mRNA. Translation: AAH83678.1 .
RefSeqi NP_001007644.1. NM_001007643.1.
UniGenei Rn.3027.

3D structure databases

ProteinModelPortali Q5XIK2.
SMRi Q5XIK2. Positions 137-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007914.

Proteomic databases

PaxDbi Q5XIK2.
PRIDEi Q5XIK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007914 ; ENSRNOP00000007914 ; ENSRNOG00000005308 .
GeneIDi 295701.
KEGGi rno:295701.
UCSCi RGD:1359456. rat.

Organism-specific databases

CTDi 51075.
RGDi 1359456. Tmx2.

Phylogenomic databases

eggNOGi NOG256458.
GeneTreei ENSGT00390000003751.
HOGENOMi HOG000007149.
InParanoidi Q5XIK2.
OMAi SKAGDNI.
OrthoDBi EOG718KCN.
PhylomeDBi Q5XIK2.
TreeFami TF314606.

Miscellaneous databases

NextBioi 639918.
PROi Q5XIK2.

Gene expression databases

Genevestigatori Q5XIK2.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTMX2_RAT
AccessioniPrimary (citable) accession number: Q5XIK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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