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Protein

Dynein regulatory complex subunit 2

Gene

Ccdc65

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex subunit 2By similarity
Alternative name(s):
Coiled-coil domain-containing protein 65
Gene namesi
Name:Ccdc65
Synonyms:Drc2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1595842 Ccdc65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847811 – 502Dynein regulatory complex subunit 2Add BLAST502

Proteomic databases

PaxDbiQ5XIJ8
PRIDEiQ5XIJ8

Expressioni

Gene expression databases

BgeeiENSRNOG00000058916
GenevisibleiQ5XIJ8 RN

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050912

Structurei

3D structure databases

ProteinModelPortaliQ5XIJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 160Sequence analysisAdd BLAST65
Coiled coili252 – 285Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the DRC2 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE4Y Eukaryota
ENOG410XQTS LUCA
GeneTreeiENSGT00730000111193
HOGENOMiHOG000059628
HOVERGENiHBG103693
InParanoidiQ5XIJ8
OMAiCKDNVIK
OrthoDBiEOG091G0BMS
PhylomeDBiQ5XIJ8
TreeFamiTF326074

Sequencei

Sequence statusi: Complete.

Q5XIJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKGKKPKL PLTDEEQLIL FQQKLLADEE AAKKKERLLT QFLKDKLAKE
60 70 80 90 100
EHNSSLNLNK INTQWRTVLR EVKTRELHKD IEILSQIFER VVDCKDSVIK
110 120 130 140 150
SLARDLTEAE EQYAHALRGH LHNVDQLLTL QRRRLSLLEE NYNMELEVLT
160 170 180 190 200
KEFETERKAI LDHHDKEIHY LHDVFMAMEQ NYVDSEYESK LEFQSMWDDL
210 220 230 240 250
KNKNLEEKHF LRLQLENVVE DLWRRFQDAL KNYTDATEDR KIAFETLKVK
260 270 280 290 300
DEKSSKEIEV QMKKIQRLQE AISALKGKIV AHSREGEWQN QCIRNDKELV
310 320 330 340 350
HVQLRKLKIQ RTQARTESQE NLVKLTLESN ATLKALKKVV EKGEKILKLA
360 370 380 390 400
EICRKFETEE EKVLPFYSSA LTPEEQEEVE IQSQEEITED LAKIMMDYLG
410 420 430 440 450
MENFWKRYNK VKLEVLSLQH RRLQLLDISS KLREMLKQYL DGISVSDEVL
460 470 480 490 500
SRLNPLFIVN HKSNLPQLPP SAAQPGGDRG PGGDRRLTYN VIEAAHIASH

IL
Length:502
Mass (Da):59,004
Last modified:November 23, 2004 - v1
Checksum:i0EF92278761B5026
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083683 mRNA Translation: AAH83683.1
RefSeqiNP_001014225.1, NM_001014203.1
UniGeneiRn.34654

Genome annotation databases

EnsembliENSRNOT00000090760; ENSRNOP00000071850; ENSRNOG00000058916
GeneIDi362994
KEGGirno:362994
UCSCiRGD:1595842 rat

Similar proteinsi

Entry informationi

Entry nameiDRC2_RAT
AccessioniPrimary (citable) accession number: Q5XIJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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