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Protein

BRISC and BRCA1-A complex member 1

Gene

Babam1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-RNO-5693571. Nonhomologous End-Joining (NHEJ).
R-RNO-69473. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
BRISC and BRCA1-A complex member 1
Alternative name(s):
Mediator of RAP80 interactions and targeting subunit of 40 kDa
New component of the BRCA1-A complex
Gene namesi
Name:Babam1
Synonyms:Merit40, Nba1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1359516. Babam1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localizes at sites of DNA damage at double-strand breaks (DSBs).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884611 – 334BRISC and BRCA1-A complex member 1Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei8PhosphoserineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Modified residuei54PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XIJ6.
PRIDEiQ5XIJ6.

PTM databases

iPTMnetiQ5XIJ6.
PhosphoSitePlusiQ5XIJ6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017071.
GenevisibleiQ5XIJ6. RN.

Interactioni

Subunit structurei

Component of the ARISC complex, at least composed of UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas and BRE/BRCC45. Component of the BRISC complex, at least composed of FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex.By similarity

Protein-protein interaction databases

BioGridi253253. 2 interactors.
STRINGi10116.ENSRNOP00000022938.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 303VWFA-likeAdd BLAST204

Domaini

The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.By similarity

Sequence similaritiesi

Belongs to the BABAM1 family.Curated

Phylogenomic databases

eggNOGiENOG410IF7E. Eukaryota.
ENOG4111NFW. LUCA.
GeneTreeiENSGT00390000016934.
InParanoidiQ5XIJ6.
KOiK20776.
OMAiRPFQSHA.
OrthoDBiEOG091G0SJH.
PhylomeDBiQ5XIJ6.
TreeFamiTF329070.

Family and domain databases

InterProiIPR026126. BABAM1.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR15660. PTHR15660. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XIJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAEANSPT EEEEEEEEEE GEEPISEPRP HTRSNPEGAE DRAIGAQANV
60 70 80 90 100
GSRSEGEGEA ATADDGAASV PGAVPKPWQV PAPASEVQIR TPRVNCPEKV
110 120 130 140 150
IICLDLSEEM SVPKLESFNG SRTNALNVSQ KMVEMFVRTK HKIDKSHEFA
160 170 180 190 200
LVVVNDDSAW LSGLTSDPRE LCSCLYDLET ASCSTFNLEG LFSLIQQKTE
210 220 230 240 250
LPVTENVQTI PPPYVVRTIL VYSRPPCQPQ FSLTEPMKKM FQCPYFFFDI
260 270 280 290 300
IYIHSGPEEK EDDMSWKDMF AFMGSLDTKG TSYKYAVALA GPALELHNCV
310 320 330
AKLLAHPLQR PCQSHASYSL LEEDEEAGEG EATV
Length:334
Mass (Da):36,878
Last modified:November 23, 2004 - v1
Checksum:i856B099DC0BCC85C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083685 mRNA. Translation: AAH83685.1.
RefSeqiNP_001006965.1. NM_001006964.1.
XP_006252919.1. XM_006252857.3.
UniGeneiRn.74107.

Genome annotation databases

EnsembliENSRNOT00000022938; ENSRNOP00000022938; ENSRNOG00000017071.
GeneIDi290631.
KEGGirno:290631.
UCSCiRGD:1359516. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083685 mRNA. Translation: AAH83685.1.
RefSeqiNP_001006965.1. NM_001006964.1.
XP_006252919.1. XM_006252857.3.
UniGeneiRn.74107.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi253253. 2 interactors.
STRINGi10116.ENSRNOP00000022938.

PTM databases

iPTMnetiQ5XIJ6.
PhosphoSitePlusiQ5XIJ6.

Proteomic databases

PaxDbiQ5XIJ6.
PRIDEiQ5XIJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022938; ENSRNOP00000022938; ENSRNOG00000017071.
GeneIDi290631.
KEGGirno:290631.
UCSCiRGD:1359516. rat.

Organism-specific databases

CTDi29086.
RGDi1359516. Babam1.

Phylogenomic databases

eggNOGiENOG410IF7E. Eukaryota.
ENOG4111NFW. LUCA.
GeneTreeiENSGT00390000016934.
InParanoidiQ5XIJ6.
KOiK20776.
OMAiRPFQSHA.
OrthoDBiEOG091G0SJH.
PhylomeDBiQ5XIJ6.
TreeFamiTF329070.

Enzyme and pathway databases

ReactomeiR-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-RNO-5693571. Nonhomologous End-Joining (NHEJ).
R-RNO-69473. G2/M DNA damage checkpoint.

Miscellaneous databases

PROiQ5XIJ6.

Gene expression databases

BgeeiENSRNOG00000017071.
GenevisibleiQ5XIJ6. RN.

Family and domain databases

InterProiIPR026126. BABAM1.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR15660. PTHR15660. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBABA1_RAT
AccessioniPrimary (citable) accession number: Q5XIJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.