Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Telomerase Cajal body protein 1

Gene

Wrap53

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase Cajal body protein 1
Alternative name(s):
WD repeat-containing protein 79
WD repeat-containing protein WRAP53
WD40 repeat-containing protein antisense to TP53 gene
Gene namesi
Name:Wrap53
Synonyms:Tcab1, Wdr79
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359624. Wrap53.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Telomerase Cajal body protein 1PRO_0000242698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271PhosphoserineCombined sources
Modified residuei61 – 611PhosphoserineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity
Modified residuei474 – 4741PhosphothreonineBy similarity
Modified residuei476 – 4761PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XII5.
PRIDEiQ5XII5.

PTM databases

iPTMnetiQ5XII5.
PhosphoSiteiQ5XII5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010520.
GenevisibleiQ5XII5. RN.

Interactioni

Subunit structurei

Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014261.

Structurei

3D structure databases

ProteinModelPortaliQ5XII5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati151 – 19040WD 1Add
BLAST
Repeati206 – 25146WD 2Add
BLAST
Repeati256 – 29742WD 3Add
BLAST
Repeati307 – 34842WD 4Add
BLAST
Repeati349 – 38941WD 5Add
BLAST
Repeati395 – 43440WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2919. Eukaryota.
ENOG410XS4K. LUCA.
GeneTreeiENSGT00390000010169.
HOGENOMiHOG000030352.
HOVERGENiHBG098609.
InParanoidiQ5XII5.
OMAiPPELYHE.
OrthoDBiEOG091G0FP1.
PhylomeDBiQ5XII5.
TreeFamiTF315169.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XII5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSEELRLA PDSLPSDLVP APVLQASPAD KNTDSEPVPP PCGGDDQLQV
60 70 80 90 100
ATDAVASSVV SQELQQGDSA PLEVEFNISS ELSPRIEEQE VPENASLPVE
110 120 130 140 150
ETNRPELESG EAMEGVSEEP AAVDEGDIFW SYSFSQVPQY LSGSWSEFST
160 170 180 190 200
RSENFLKGCK WAPDGSCILT NSADNVLRIY NLPPELYSES EQVDYAEMVP
210 220 230 240 250
VLRMVEGDTI YDYCWYSLMS STQPDTSYVA SSSRENPIHI WDAFTGELRA
260 270 280 290 300
SFRAYNHLDE LTAAHSLCFS PDGSQLFCGF NRTVRVFSTS RPGRDCEVRT
310 320 330 340 350
TFAKKQGQSG IISCLAFSPA QPLYACGSYG RTLGLYAWDD GSPLALLGGH
360 370 380 390 400
QGGITHLCFH PDGNLFFSGA RKDAELLCWD LRQPGHLLWS LSREVTTNQR
410 420 430 440 450
IYFDLDPSGQ FLVSGNTSGV VSVWDISGAF SDCKQLEPVM TFLPQDDCTN
460 470 480 490 500
GVSLHPTLPL LATASGQRMF PEPTNSGDEG EPELDLPLLS LRHAHPECQL
510 520 530
QLWWCGGGPD PSNPDEDQDE KGQGRTEAVG MS
Length:532
Mass (Da):58,195
Last modified:November 23, 2004 - v1
Checksum:i5A0A44F0CB08D84D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083696 mRNA. Translation: AAH83696.1.
RefSeqiNP_001007611.1. NM_001007610.1.
UniGeneiRn.23316.

Genome annotation databases

EnsembliENSRNOT00000014261; ENSRNOP00000014261; ENSRNOG00000010520.
GeneIDi287432.
KEGGirno:287432.
UCSCiRGD:1359624. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083696 mRNA. Translation: AAH83696.1.
RefSeqiNP_001007611.1. NM_001007610.1.
UniGeneiRn.23316.

3D structure databases

ProteinModelPortaliQ5XII5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014261.

PTM databases

iPTMnetiQ5XII5.
PhosphoSiteiQ5XII5.

Proteomic databases

PaxDbiQ5XII5.
PRIDEiQ5XII5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014261; ENSRNOP00000014261; ENSRNOG00000010520.
GeneIDi287432.
KEGGirno:287432.
UCSCiRGD:1359624. rat.

Organism-specific databases

CTDi55135.
RGDi1359624. Wrap53.

Phylogenomic databases

eggNOGiKOG2919. Eukaryota.
ENOG410XS4K. LUCA.
GeneTreeiENSGT00390000010169.
HOGENOMiHOG000030352.
HOVERGENiHBG098609.
InParanoidiQ5XII5.
OMAiPPELYHE.
OrthoDBiEOG091G0FP1.
PhylomeDBiQ5XII5.
TreeFamiTF315169.

Miscellaneous databases

PROiQ5XII5.

Gene expression databases

BgeeiENSRNOG00000010520.
GenevisibleiQ5XII5. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWAP53_RAT
AccessioniPrimary (citable) accession number: Q5XII5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.