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Protein

Tripartite motif-containing protein 54

Gene

Trim54

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May bind and stabilize microtubules during myotubes formation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 54
Alternative name(s):
RING finger protein 30
Gene namesi
Name:Trim54
Synonyms:Rnf30
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1306453. Trim54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Tripartite motif-containing protein 54PRO_0000056285Add
BLAST

Proteomic databases

PaxDbiQ5XIH6.

Expressioni

Gene expression databases

GenevisibleiQ5XIH6. RN.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55. Interacts with tubulin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008113.

Structurei

3D structure databases

ProteinModelPortaliQ5XIH6.
SMRiQ5XIH6. Positions 118-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 32959COSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 21144Mediates microtubule-binding and homooligomerizationBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili194 – 25259Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG3. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOVERGENiHBG071242.
InParanoidiQ5XIH6.
KOiK10653.
OMAiGYESMDQ.
OrthoDBiEOG7VDXPK.
PhylomeDBiQ5XIH6.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTVGFKPL LGDAHNMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHSKA EQHLMCEEHE DEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEDNSRRQK QLLNQKFETL CAVLEERKGE LLQALARVQE EKLQRVRSLI
260 270 280 290 300
RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
310 320 330 340 350
RPEPGYESME QFSVIVEHVA EMLRTIDFQP GASGDEEDDE VTLDGEEGNT
360
GLEEERLDGP EGLH
Length:364
Mass (Da):41,031
Last modified:November 23, 2004 - v1
Checksum:i30D0B386B085016C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083706 mRNA. Translation: AAH83706.1.
RefSeqiNP_001013235.1. NM_001013217.1.
UniGeneiRn.6303.

Genome annotation databases

EnsembliENSRNOT00000008113; ENSRNOP00000008113; ENSRNOG00000006146.
GeneIDi362708.
KEGGirno:362708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083706 mRNA. Translation: AAH83706.1.
RefSeqiNP_001013235.1. NM_001013217.1.
UniGeneiRn.6303.

3D structure databases

ProteinModelPortaliQ5XIH6.
SMRiQ5XIH6. Positions 118-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008113.

Proteomic databases

PaxDbiQ5XIH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008113; ENSRNOP00000008113; ENSRNOG00000006146.
GeneIDi362708.
KEGGirno:362708.

Organism-specific databases

CTDi57159.
RGDi1306453. Trim54.

Phylogenomic databases

eggNOGiENOG410ITG3. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOVERGENiHBG071242.
InParanoidiQ5XIH6.
KOiK10653.
OMAiGYESMDQ.
OrthoDBiEOG7VDXPK.
PhylomeDBiQ5XIH6.

Miscellaneous databases

PROiQ5XIH6.

Gene expression databases

GenevisibleiQ5XIH6. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiTRI54_RAT
AccessioniPrimary (citable) accession number: Q5XIH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.