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Protein

Serine-threonine kinase receptor-associated protein

Gene

Strap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-2173788. Downregulation of TGF-beta receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-threonine kinase receptor-associated protein
Alternative name(s):
UNR-interacting protein
Gene namesi
Name:Strap
Synonyms:Unrip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1311114. Strap.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localized predominantly in the cytoplasm but also found in the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Serine-threonine kinase receptor-associated proteinPRO_0000288476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei338 – 3381PhosphoserineCombined sources
Modified residuei342 – 3421PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIG8.
PRIDEiQ5XIG8.

PTM databases

iPTMnetiQ5XIG8.

Expressioni

Gene expression databases

GenevisibleiQ5XIG8. RN.

Interactioni

Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi255640. 1 interaction.
IntActiQ5XIG8. 1 interaction.
STRINGi10116.ENSRNOP00000009923.

Structurei

3D structure databases

ProteinModelPortaliQ5XIG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati12 – 5645WD 1Add
BLAST
Repeati57 – 9640WD 2Add
BLAST
Repeati98 – 13740WD 3Add
BLAST
Repeati141 – 17939WD 4Add
BLAST
Repeati180 – 21233WD 5Add
BLAST
Repeati221 – 26242WD 6Add
BLAST
Repeati263 – 30240WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat STRAP family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0278. Eukaryota.
ENOG410XPJ4. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000174258.
HOVERGENiHBG055228.
InParanoidiQ5XIG8.
KOiK13137.
OMAiATPLVCH.
OrthoDBiEOG7288RQ.
PhylomeDBiQ5XIG8.
TreeFamiTF323287.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD
60 70 80 90 100
WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK
110 120 130 140 150
HIVKTVDFTQ DSNYLLTGGQ DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL
160 170 180 190 200
WCSEDKQILS ADDKTVRLWD HATMTEVKSL NFNMSVSSME YIPEGEILVI
210 220 230 240 250
TYGRSIAFHS AVSLEPIKSF EAPATINSAS LHPEKEFLVA GGEDFKLYKY
260 270 280 290 300
DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY
310 320 330 340 350
GLWKCVLPEE DSGELAKPKI GFPETAEEEL EEIASENSDS IYSSTPEVKA
Length:350
Mass (Da):38,456
Last modified:November 23, 2004 - v1
Checksum:iF2482082247FA5E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083714 mRNA. Translation: AAH83714.1.
RefSeqiNP_001011969.1. NM_001011969.1.
UniGeneiRn.228807.

Genome annotation databases

EnsembliENSRNOT00000009923; ENSRNOP00000009923; ENSRNOG00000007134.
GeneIDi297699.
KEGGirno:297699.
UCSCiRGD:1311114. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083714 mRNA. Translation: AAH83714.1.
RefSeqiNP_001011969.1. NM_001011969.1.
UniGeneiRn.228807.

3D structure databases

ProteinModelPortaliQ5XIG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255640. 1 interaction.
IntActiQ5XIG8. 1 interaction.
STRINGi10116.ENSRNOP00000009923.

PTM databases

iPTMnetiQ5XIG8.

Proteomic databases

PaxDbiQ5XIG8.
PRIDEiQ5XIG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009923; ENSRNOP00000009923; ENSRNOG00000007134.
GeneIDi297699.
KEGGirno:297699.
UCSCiRGD:1311114. rat.

Organism-specific databases

CTDi11171.
RGDi1311114. Strap.

Phylogenomic databases

eggNOGiKOG0278. Eukaryota.
ENOG410XPJ4. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000174258.
HOVERGENiHBG055228.
InParanoidiQ5XIG8.
KOiK13137.
OMAiATPLVCH.
OrthoDBiEOG7288RQ.
PhylomeDBiQ5XIG8.
TreeFamiTF323287.

Enzyme and pathway databases

ReactomeiR-RNO-2173788. Downregulation of TGF-beta receptor signaling.

Miscellaneous databases

PROiQ5XIG8.

Gene expression databases

GenevisibleiQ5XIG8. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 273-290, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTRAP_RAT
AccessioniPrimary (citable) accession number: Q5XIG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.