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Protein

N-acetylgalactosamine kinase

Gene

Galk2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity).By similarity

Catalytic activityi

ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei43Transition state stabilizerBy similarity1
Active sitei190Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 149ATPSequence analysisAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine kinase (EC:2.7.1.157)
Alternative name(s):
GalNAc kinase
Galactokinase 2
Gene namesi
Name:Galk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1308691 Galk2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846501 – 458N-acetylgalactosamine kinaseAdd BLAST458

Proteomic databases

PaxDbiQ5XIG6
PRIDEiQ5XIG6

Expressioni

Gene expression databases

BgeeiENSRNOG00000009289
ExpressionAtlasiQ5XIG6 baseline and differential
GenevisibleiQ5XIG6 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012447

Structurei

3D structure databases

ProteinModelPortaliQ5XIG6
SMRiQ5XIG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 52Substrate bindingBy similarity4
Regioni187 – 190Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.Curated

Phylogenomic databases

eggNOGiKOG0631 Eukaryota
COG0153 LUCA
GeneTreeiENSGT00530000063433
HOGENOMiHOG000241099
HOVERGENiHBG051696
InParanoidiQ5XIG6
KOiK18674
OMAiYECSHPD
PhylomeDBiQ5XIG6
TreeFamiTF324235

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000705 Galactokinase
IPR019741 Galactokinase_CS
IPR019539 GalKase_gal-bd
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR006206 Mevalonate/galactokinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF10509 GalKase_gal_bdg, 1 hit
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000530 Galactokinase, 1 hit
PRINTSiPR00473 GALCTOKINASE
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 2 hits
TIGRFAMsiTIGR00131 gal_kin, 1 hit
PROSITEiView protein in PROSITE
PS00106 GALACTOKINASE, 1 hit
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XIG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDPATRR VQVAEHPRLL KLKEMFNSKF GSTPKFYVRA PGRVNIIGEH
60 70 80 90 100
IDYCGYSVLP MAVEQDMLIA VGPVKTQTLQ LANTDPLYPD FSTTANNICI
110 120 130 140 150
DKTQPLWHNY FLCGFKGIQE HFGLTQLPGM NCLVDGNIPP SSGLSSSSAL
160 170 180 190 200
VCCAGLVTLT VLGMRLSKVE LAEICAKSER YIGTEGGGMD QSISFLAEEG
210 220 230 240 250
TAKLIEFSPL RATDVKLPSG AVFVIANSCV EMNKAATSHF NVRVMECRLA
260 270 280 290 300
AKVLAKHKGL QWDKVLRLEE VQSELGISLE EMLLVTEDAL HAEPYSREEI
310 320 330 340 350
CKCLGISLEE LRTQILSPNT QGELTFKLYQ RAKHVYSEAA RVLQFKQVCE
360 370 380 390 400
AAPDNAVQLL GELMNQSHRS CRDMYECSCP ELDQLVDICR KFGAKGSRLT
410 420 430 440 450
GAGWGGCTVS LVPADTLSSF LASVHEAYYQ GNMSRLAREK HSLFATKPGG

GALVFLEA
Length:458
Mass (Da):50,198
Last modified:November 23, 2004 - v1
Checksum:i4F582ACF66DB3231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083716 mRNA Translation: AAH83716.1
RefSeqiNP_001013941.1, NM_001013919.1
UniGeneiRn.2937

Genome annotation databases

EnsembliENSRNOT00000012447; ENSRNOP00000012447; ENSRNOG00000009289
ENSRNOT00000079023; ENSRNOP00000069500; ENSRNOG00000009289
GeneIDi296117
KEGGirno:296117
UCSCiRGD:1308691 rat

Similar proteinsi

Entry informationi

Entry nameiGALK2_RAT
AccessioniPrimary (citable) accession number: Q5XIG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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