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Q5XIG6 (GALK2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetylgalactosamine kinase
EC=2.7.1.157
Alternative name(s):
GalNAc kinase
Galactokinase 2
Gene names
Name:Galk2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations By similarity.

Catalytic activity

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the GHMP kinase family. GalK subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458N-acetylgalactosamine kinase
PRO_0000184650

Regions

Nucleotide binding139 – 14911ATP Potential
Region49 – 524Substrate binding By similarity
Region187 – 1904Substrate binding By similarity

Sites

Active site1901Proton acceptor By similarity
Site431Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XIG6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 4F582ACF66DB3231

FASTA45850,198
        10         20         30         40         50         60 
MAAEDPATRR VQVAEHPRLL KLKEMFNSKF GSTPKFYVRA PGRVNIIGEH IDYCGYSVLP 

        70         80         90        100        110        120 
MAVEQDMLIA VGPVKTQTLQ LANTDPLYPD FSTTANNICI DKTQPLWHNY FLCGFKGIQE 

       130        140        150        160        170        180 
HFGLTQLPGM NCLVDGNIPP SSGLSSSSAL VCCAGLVTLT VLGMRLSKVE LAEICAKSER 

       190        200        210        220        230        240 
YIGTEGGGMD QSISFLAEEG TAKLIEFSPL RATDVKLPSG AVFVIANSCV EMNKAATSHF 

       250        260        270        280        290        300 
NVRVMECRLA AKVLAKHKGL QWDKVLRLEE VQSELGISLE EMLLVTEDAL HAEPYSREEI 

       310        320        330        340        350        360 
CKCLGISLEE LRTQILSPNT QGELTFKLYQ RAKHVYSEAA RVLQFKQVCE AAPDNAVQLL 

       370        380        390        400        410        420 
GELMNQSHRS CRDMYECSCP ELDQLVDICR KFGAKGSRLT GAGWGGCTVS LVPADTLSSF 

       430        440        450 
LASVHEAYYQ GNMSRLAREK HSLFATKPGG GALVFLEA

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC083716 mRNA. Translation: AAH83716.1.
IPIIPI00373115.
RefSeqNP_001013941.1. NM_001013919.1.
UniGeneRn.2937.

3D structure databases

ProteinModelPortalQ5XIG6.
SMRQ5XIG6. Positions 2-458.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012447.

Proteomic databases

PaxDbQ5XIG6.
PRIDEQ5XIG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012447; ENSRNOP00000012447; ENSRNOG00000009289.
GeneID296117.
KEGGrno:296117.
UCSCRGD:1308691. rat.

Organism-specific databases

CTD2585.
RGD1308691. Galk2.

Phylogenomic databases

eggNOGCOG0153.
GeneTreeENSGT00530000063433.
HOGENOMHOG000241099.
HOVERGENHBG051696.
InParanoidQ5XIG6.
KOK00849.
OMALKGIQEH.
OrthoDBEOG441QBG.

Gene expression databases

GenevestigatorQ5XIG6.
GermOnlineENSRNOG00000009289. Rattus norvegicus.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
InterProIPR000705. Galactokinase.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000530. Galactokinase. 1 hit.
PRINTSPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00131. gal_kin. 1 hit.
PROSITEPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio640601.

Entry information

Entry nameGALK2_RAT
AccessionPrimary (citable) accession number: Q5XIG6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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