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Protein

N-acetylgalactosamine kinase

Gene

Galk2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity).By similarity

Catalytic activityi

ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei43 – 431Transition state stabilizerBy similarity
Active sitei190 – 1901Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 14911ATPSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine kinase (EC:2.7.1.157)
Alternative name(s):
GalNAc kinase
Galactokinase 2
Gene namesi
Name:Galk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1308691. Galk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458N-acetylgalactosamine kinasePRO_0000184650Add
BLAST

Proteomic databases

PaxDbiQ5XIG6.
PRIDEiQ5XIG6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009289.
ExpressionAtlasiQ5XIG6. baseline and differential.
GenevisibleiQ5XIG6. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012447.

Structurei

3D structure databases

ProteinModelPortaliQ5XIG6.
SMRiQ5XIG6. Positions 2-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 524Substrate bindingBy similarity
Regioni187 – 1904Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.Curated

Phylogenomic databases

eggNOGiKOG0631. Eukaryota.
COG0153. LUCA.
GeneTreeiENSGT00530000063433.
HOGENOMiHOG000241099.
HOVERGENiHBG051696.
InParanoidiQ5XIG6.
KOiK18674.
OMAiLKRDYYA.
PhylomeDBiQ5XIG6.
TreeFamiTF324235.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 2 hits.
InterProiIPR000705. Galactokinase.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 2 hits.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 2 hits.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDPATRR VQVAEHPRLL KLKEMFNSKF GSTPKFYVRA PGRVNIIGEH
60 70 80 90 100
IDYCGYSVLP MAVEQDMLIA VGPVKTQTLQ LANTDPLYPD FSTTANNICI
110 120 130 140 150
DKTQPLWHNY FLCGFKGIQE HFGLTQLPGM NCLVDGNIPP SSGLSSSSAL
160 170 180 190 200
VCCAGLVTLT VLGMRLSKVE LAEICAKSER YIGTEGGGMD QSISFLAEEG
210 220 230 240 250
TAKLIEFSPL RATDVKLPSG AVFVIANSCV EMNKAATSHF NVRVMECRLA
260 270 280 290 300
AKVLAKHKGL QWDKVLRLEE VQSELGISLE EMLLVTEDAL HAEPYSREEI
310 320 330 340 350
CKCLGISLEE LRTQILSPNT QGELTFKLYQ RAKHVYSEAA RVLQFKQVCE
360 370 380 390 400
AAPDNAVQLL GELMNQSHRS CRDMYECSCP ELDQLVDICR KFGAKGSRLT
410 420 430 440 450
GAGWGGCTVS LVPADTLSSF LASVHEAYYQ GNMSRLAREK HSLFATKPGG

GALVFLEA
Length:458
Mass (Da):50,198
Last modified:November 23, 2004 - v1
Checksum:i4F582ACF66DB3231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083716 mRNA. Translation: AAH83716.1.
RefSeqiNP_001013941.1. NM_001013919.1.
UniGeneiRn.2937.

Genome annotation databases

EnsembliENSRNOT00000012447; ENSRNOP00000012447; ENSRNOG00000009289.
ENSRNOT00000079023; ENSRNOP00000069500; ENSRNOG00000009289.
GeneIDi296117.
KEGGirno:296117.
UCSCiRGD:1308691. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083716 mRNA. Translation: AAH83716.1.
RefSeqiNP_001013941.1. NM_001013919.1.
UniGeneiRn.2937.

3D structure databases

ProteinModelPortaliQ5XIG6.
SMRiQ5XIG6. Positions 2-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012447.

Proteomic databases

PaxDbiQ5XIG6.
PRIDEiQ5XIG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012447; ENSRNOP00000012447; ENSRNOG00000009289.
ENSRNOT00000079023; ENSRNOP00000069500; ENSRNOG00000009289.
GeneIDi296117.
KEGGirno:296117.
UCSCiRGD:1308691. rat.

Organism-specific databases

CTDi2585.
RGDi1308691. Galk2.

Phylogenomic databases

eggNOGiKOG0631. Eukaryota.
COG0153. LUCA.
GeneTreeiENSGT00530000063433.
HOGENOMiHOG000241099.
HOVERGENiHBG051696.
InParanoidiQ5XIG6.
KOiK18674.
OMAiLKRDYYA.
PhylomeDBiQ5XIG6.
TreeFamiTF324235.

Miscellaneous databases

PROiQ5XIG6.

Gene expression databases

BgeeiENSRNOG00000009289.
ExpressionAtlasiQ5XIG6. baseline and differential.
GenevisibleiQ5XIG6. RN.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 2 hits.
InterProiIPR000705. Galactokinase.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 2 hits.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 2 hits.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALK2_RAT
AccessioniPrimary (citable) accession number: Q5XIG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.