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Protein

ADP-ribose pyrophosphatase, mitochondrial

Gene

Nudt9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

Catalytic activityi

ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese

Enzyme and pathway databases

ReactomeiR-RNO-2393930 Phosphate bond hydrolysis by NUDT proteins
SABIO-RKQ5XIG0

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribose pyrophosphatase, mitochondrial (EC:3.6.1.13)
Alternative name(s):
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
Adenosine diphosphoribose pyrophosphatase
Short name:
ADPR-PPase
Nucleoside diphosphate-linked moiety X motif 9
Short name:
Nudix motif 9
Gene namesi
Name:Nudt9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1359522 Nudt9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
ChainiPRO_000001995247 – 350ADP-ribose pyrophosphatase, mitochondrialAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIG0
PRIDEiQ5XIG0

PTM databases

iPTMnetiQ5XIG0
PhosphoSitePlusiQ5XIG0

Expressioni

Gene expression databases

BgeeiENSRNOG00000002186
GenevisibleiQ5XIG0 RN

Interactioni

Subunit structurei

Monomer. Interacts with GLOD4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002973

Structurei

3D structure databases

ProteinModelPortaliQ5XIG0
SMRiQ5XIG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 334Nudix hydrolasePROSITE-ProRule annotationAdd BLAST157

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi215 – 237Nudix boxAdd BLAST23

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudF subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4195 Eukaryota
ENOG410XPYY LUCA
GeneTreeiENSGT00390000017405
HOGENOMiHOG000130166
HOVERGENiHBG052693
InParanoidiQ5XIG0
KOiK13988
OMAiDDFRNTD
OrthoDBiEOG091G0H75
PhylomeDBiQ5XIG0
TreeFamiTF106351

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSLGKAV ATVSLSVALA SVTVRSSGCR AIPAPRNPFP SCGFHLKANI
60 70 80 90 100
MSGSNGVKDN SHNKARTSPY PGSKVERSKV PNEKVGWLVE WQDYNPVEYT
110 120 130 140 150
AVSVLAGPQW ADPQISESSF SPRFNEKDGH VERKSQNGLY EIENGRPRNP
160 170 180 190 200
AGRTGLVGRG LLGRWGPNHA ADPIITRWKR DESGNKITHP VSGKCILQFV
210 220 230 240 250
AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ KSSAEKREIE
260 270 280 290 300
EKLHALFSQE HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGETMDNLTL
310 320 330 340 350
EAGDDAGKVK WVDISDQLKL YASHSQFIKL VAEKRDAHWS EDCAADSHGL
Length:350
Mass (Da):38,562
Last modified:November 23, 2004 - v1
Checksum:iCB85E68713BD242C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083722 mRNA Translation: AAH83722.1
RefSeqiNP_001006992.1, NM_001006991.1
UniGeneiRn.22103

Genome annotation databases

EnsembliENSRNOT00000002973; ENSRNOP00000002973; ENSRNOG00000002186
GeneIDi305149
KEGGirno:305149

Similar proteinsi

Entry informationi

Entry nameiNUDT9_RAT
AccessioniPrimary (citable) accession number: Q5XIG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health