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Protein

ADP-ribose pyrophosphatase, mitochondrial

Gene

Nudt9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

Catalytic activityi

ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese

Enzyme and pathway databases

ReactomeiR-RNO-2393930. Phosphate bond hydrolysis by NUDT proteins.
SABIO-RKQ5XIG0.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribose pyrophosphatase, mitochondrial (EC:3.6.1.13)
Alternative name(s):
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
Adenosine diphosphoribose pyrophosphatase
Short name:
ADPR-PPase
Nucleoside diphosphate-linked moiety X motif 9
Short name:
Nudix motif 9
Gene namesi
Name:Nudt9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1359522. Nudt9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4646MitochondrionSequence analysisAdd
BLAST
Chaini47 – 350304ADP-ribose pyrophosphatase, mitochondrialPRO_0000019952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei121 – 1211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIG0.
PRIDEiQ5XIG0.

PTM databases

iPTMnetiQ5XIG0.
PhosphoSiteiQ5XIG0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002186.
GenevisibleiQ5XIG0. RN.

Interactioni

Subunit structurei

Monomer. Interacts with GLOD4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002973.

Structurei

3D structure databases

ProteinModelPortaliQ5XIG0.
SMRiQ5XIG0. Positions 59-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 334157Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi215 – 23723Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudF subfamily.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4195. Eukaryota.
ENOG410XPYY. LUCA.
GeneTreeiENSGT00390000017405.
HOGENOMiHOG000130166.
HOVERGENiHBG052693.
InParanoidiQ5XIG0.
KOiK13988.
OMAiQISESNF.
OrthoDBiEOG091G0H75.
PhylomeDBiQ5XIG0.
TreeFamiTF106351.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSLGKAV ATVSLSVALA SVTVRSSGCR AIPAPRNPFP SCGFHLKANI
60 70 80 90 100
MSGSNGVKDN SHNKARTSPY PGSKVERSKV PNEKVGWLVE WQDYNPVEYT
110 120 130 140 150
AVSVLAGPQW ADPQISESSF SPRFNEKDGH VERKSQNGLY EIENGRPRNP
160 170 180 190 200
AGRTGLVGRG LLGRWGPNHA ADPIITRWKR DESGNKITHP VSGKCILQFV
210 220 230 240 250
AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ KSSAEKREIE
260 270 280 290 300
EKLHALFSQE HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGETMDNLTL
310 320 330 340 350
EAGDDAGKVK WVDISDQLKL YASHSQFIKL VAEKRDAHWS EDCAADSHGL
Length:350
Mass (Da):38,562
Last modified:November 23, 2004 - v1
Checksum:iCB85E68713BD242C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083722 mRNA. Translation: AAH83722.1.
RefSeqiNP_001006992.1. NM_001006991.1.
UniGeneiRn.22103.

Genome annotation databases

EnsembliENSRNOT00000002973; ENSRNOP00000002973; ENSRNOG00000002186.
GeneIDi305149.
KEGGirno:305149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083722 mRNA. Translation: AAH83722.1.
RefSeqiNP_001006992.1. NM_001006991.1.
UniGeneiRn.22103.

3D structure databases

ProteinModelPortaliQ5XIG0.
SMRiQ5XIG0. Positions 59-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002973.

PTM databases

iPTMnetiQ5XIG0.
PhosphoSiteiQ5XIG0.

Proteomic databases

PaxDbiQ5XIG0.
PRIDEiQ5XIG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002973; ENSRNOP00000002973; ENSRNOG00000002186.
GeneIDi305149.
KEGGirno:305149.

Organism-specific databases

CTDi53343.
RGDi1359522. Nudt9.

Phylogenomic databases

eggNOGiKOG4195. Eukaryota.
ENOG410XPYY. LUCA.
GeneTreeiENSGT00390000017405.
HOGENOMiHOG000130166.
HOVERGENiHBG052693.
InParanoidiQ5XIG0.
KOiK13988.
OMAiQISESNF.
OrthoDBiEOG091G0H75.
PhylomeDBiQ5XIG0.
TreeFamiTF106351.

Enzyme and pathway databases

ReactomeiR-RNO-2393930. Phosphate bond hydrolysis by NUDT proteins.
SABIO-RKQ5XIG0.

Miscellaneous databases

PROiQ5XIG0.

Gene expression databases

BgeeiENSRNOG00000002186.
GenevisibleiQ5XIG0. RN.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDT9_RAT
AccessioniPrimary (citable) accession number: Q5XIG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.