Reviewed, UniProtKB/Swiss-Prot Q5XIG0 (NUDT9_RAT)

Names and origin

Protein names

Recommended name:
    ADP-ribose pyrophosphatase, mitochondrial
    EC=3.6.1.13
Alternative name(s):
    ADP-ribose diphosphatase
    Adenosine diphosphoribose pyrophosphatase
      Short name=ADPR-PPase
    ADP-ribose phosphohydrolase
    Nucleoside diphosphate-linked moiety X motif 9
      Short name=Nudix motif 9

Gene names

Name:

Nudt9

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Catalytic activity	ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
Cofactor	Magnesium By similarity. Manganese By similarity.
Subunit structure	Monomer By similarity. Interacts with C17orf25 By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. NudF subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Magnesium Manganese
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ADP-ribose diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 46	46	Mitochondrion Potential
	Chain	47 – 350	304	ADP-ribose pyrophosphatase, mitochondrial		PRO_0000019952
Regions
	Motif	215 – 237	23	Nudix box
Amino acid modifications
	Modified residue	68	1	Phosphoserine By similarity
	Modified residue	121	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5XIG0-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: CB85E68713BD242C	FASTA	350	38,562
	10 20 30 40 50 60 MAGRSLGKAV ATVSLSVALA SVTVRSSGCR AIPAPRNPFP SCGFHLKANI MSGSNGVKDN 70 80 90 100 110 120 SHNKARTSPY PGSKVERSKV PNEKVGWLVE WQDYNPVEYT AVSVLAGPQW ADPQISESSF 130 140 150 160 170 180 SPRFNEKDGH VERKSQNGLY EIENGRPRNP AGRTGLVGRG LLGRWGPNHA ADPIITRWKR 190 200 210 220 230 240 DESGNKITHP VSGKCILQFV AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ 250 260 270 280 290 300 KSSAEKREIE EKLHALFSQE HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGETMDNLTL 310 320 330 340 350 EAGDDAGKVK WVDISDQLKL YASHSQFIKL VAEKRDAHWS EDCAADSHGL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC083722 mRNA. Translation: AAH83722.1.
IPI	IPI00198374.
RefSeq	NP_001006992.1.
UniGene	Rn.22103
3D structure databases
SMR	Q5XIG0. Positions 59-350.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000002186. Rattus norvegicus. [Contig view]
GeneID	305149.
KEGG	rno:305149.
NMPDR	fig|10116.3.peg.10006.
Organism-specific databases
RGD	1359522. Nudt9.
Phylogenomic databases
HOVERGEN	Q5XIG0.
OMA	Q5XIG0. QISESNF.
Enzyme and pathway databases
BRENDA	3.6.1.13. 248.
Gene expression databases
ArrayExpress	Q5XIG0.
GermOnline	ENSRNOG00000002186. Rattus norvegicus.
Family and domain databases
InterPro	IPR000086. NUDIX_hydrolase_core. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	654144.

Entry information

Entry name

NUDT9_RAT

Accession

Primary (citable) accession number: Q5XIG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	November 23, 2004
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)