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Protein

Small ubiquitin-related modifier 3

Gene

Sumo3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-3065679. SUMO is proteolytically processed.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3232118. SUMOylation of transcription factors.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5696395. Formation of Incision Complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3Curated
Short name:
SUMO-3Curated
Gene namesi
Name:Sumo3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1561022. Sumo3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Small ubiquitin-related modifier 3PRO_0000267626Add
BLAST
Propeptidei93 – 11018By similarityPRO_0000267627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki7 – 7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki92 – 92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5XIF4.
PRIDEiQ5XIF4.

PTM databases

iPTMnetiQ5XIF4.
PhosphoSiteiQ5XIF4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000038489.
GenevisibleiQ5XIF4. RN.

Interactioni

Subunit structurei

Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with ARNTL/BMAL1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi270726. 189 interactions.
STRINGi10116.ENSRNOP00000001637.

Structurei

3D structure databases

ProteinModelPortaliQ5XIF4.
SMRiQ5XIF4. Positions 14-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9278Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ5XIF4.
KOiK12160.
OMAiGAFCERQ.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ5XIF4.
TreeFamiTF315116.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ
60 70 80 90 100
GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGTASRASVP
110
TPSHFPDICY
Length:110
Mass (Da):12,456
Last modified:November 23, 2004 - v1
Checksum:iB055BF91A3F87639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083728 mRNA. Translation: AAH83728.1.
RefSeqiNP_001019466.1. NM_001024295.1.
UniGeneiRn.154914.

Genome annotation databases

EnsembliENSRNOT00000001637; ENSRNOP00000001637; ENSRNOG00000038489.
GeneIDi499417.
KEGGirno:499417.
UCSCiRGD:1561022. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083728 mRNA. Translation: AAH83728.1.
RefSeqiNP_001019466.1. NM_001024295.1.
UniGeneiRn.154914.

3D structure databases

ProteinModelPortaliQ5XIF4.
SMRiQ5XIF4. Positions 14-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi270726. 189 interactions.
STRINGi10116.ENSRNOP00000001637.

PTM databases

iPTMnetiQ5XIF4.
PhosphoSiteiQ5XIF4.

Proteomic databases

PaxDbiQ5XIF4.
PRIDEiQ5XIF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001637; ENSRNOP00000001637; ENSRNOG00000038489.
GeneIDi499417.
KEGGirno:499417.
UCSCiRGD:1561022. rat.

Organism-specific databases

CTDi6612.
RGDi1561022. Sumo3.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ5XIF4.
KOiK12160.
OMAiGAFCERQ.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ5XIF4.
TreeFamiTF315116.

Enzyme and pathway databases

ReactomeiR-RNO-3065679. SUMO is proteolytically processed.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3232118. SUMOylation of transcription factors.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5696395. Formation of Incision Complex in GG-NER.

Miscellaneous databases

PROiQ5XIF4.

Gene expression databases

BgeeiENSRNOG00000038489.
GenevisibleiQ5XIF4. RN.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO3_RAT
AccessioniPrimary (citable) accession number: Q5XIF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.