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Protein

Small ubiquitin-related modifier 3

Gene

Sumo3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-3065679. SUMO is proteolytically processed.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3232118. SUMOylation of transcription factors.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5696395. Formation of Incision Complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3Curated
Short name:
SUMO-3Curated
Gene namesi
Name:Sumo3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1561022. Sumo3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Small ubiquitin-related modifier 3PRO_0000267626Add
BLAST
Propeptidei93 – 11018By similarityPRO_0000267627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki7 – 7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki92 – 92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5XIF4.
PRIDEiQ5XIF4.

PTM databases

iPTMnetiQ5XIF4.
PhosphoSiteiQ5XIF4.

Expressioni

Gene expression databases

GenevisibleiQ5XIF4. RN.

Interactioni

Subunit structurei

Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with ARNTL/BMAL1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi270726. 189 interactions.
STRINGi10116.ENSRNOP00000001637.

Structurei

3D structure databases

ProteinModelPortaliQ5XIF4.
SMRiQ5XIF4. Positions 14-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9278Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ5XIF4.
KOiK12160.
OMAiNAYCDRV.
OrthoDBiEOG76X62R.
PhylomeDBiQ5XIF4.
TreeFamiTF315116.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ
60 70 80 90 100
GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGTASRASVP
110
TPSHFPDICY
Length:110
Mass (Da):12,456
Last modified:November 23, 2004 - v1
Checksum:iB055BF91A3F87639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083728 mRNA. Translation: AAH83728.1.
RefSeqiNP_001019466.1. NM_001024295.1.
UniGeneiRn.154914.

Genome annotation databases

EnsembliENSRNOT00000001637; ENSRNOP00000001637; ENSRNOG00000038489.
GeneIDi499417.
KEGGirno:499417.
UCSCiRGD:1561022. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083728 mRNA. Translation: AAH83728.1.
RefSeqiNP_001019466.1. NM_001024295.1.
UniGeneiRn.154914.

3D structure databases

ProteinModelPortaliQ5XIF4.
SMRiQ5XIF4. Positions 14-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi270726. 189 interactions.
STRINGi10116.ENSRNOP00000001637.

PTM databases

iPTMnetiQ5XIF4.
PhosphoSiteiQ5XIF4.

Proteomic databases

PaxDbiQ5XIF4.
PRIDEiQ5XIF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001637; ENSRNOP00000001637; ENSRNOG00000038489.
GeneIDi499417.
KEGGirno:499417.
UCSCiRGD:1561022. rat.

Organism-specific databases

CTDi6612.
RGDi1561022. Sumo3.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ5XIF4.
KOiK12160.
OMAiNAYCDRV.
OrthoDBiEOG76X62R.
PhylomeDBiQ5XIF4.
TreeFamiTF315116.

Enzyme and pathway databases

ReactomeiR-RNO-3065679. SUMO is proteolytically processed.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3232118. SUMOylation of transcription factors.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5696395. Formation of Incision Complex in GG-NER.

Miscellaneous databases

PROiQ5XIF4.

Gene expression databases

GenevisibleiQ5XIF4. RN.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiSUMO3_RAT
AccessioniPrimary (citable) accession number: Q5XIF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.