Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

Ndufs4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: RGD

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105 Respiratory electron transport
R-RNO-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Alternative name(s):
Complex I-18 kDa
Short name:
CI-18 kDa
NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene namesi
Name:Ndufs4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1594380 Ndufs4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionBy similarityAdd BLAST42
ChainiPRO_000025070943 – 175NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST133

Proteomic databases

PaxDbiQ5XIF3
PRIDEiQ5XIF3

PTM databases

iPTMnetiQ5XIF3
PhosphoSitePlusiQ5XIF3
SwissPalmiQ5XIF3

Expressioni

Gene expression databases

BgeeiENSRNOG00000011383
GenevisibleiQ5XIF3 RN

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi270838, 1 interactor
STRINGi10116.ENSRNOP00000015217

Structurei

3D structure databases

ProteinModelPortaliQ5XIF3
SMRiQ5XIF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3389 Eukaryota
ENOG4111TR4 LUCA
GeneTreeiENSGT00390000013835
HOGENOMiHOG000140414
HOVERGENiHBG003007
InParanoidiQ5XIF3
KOiK03937
OMAiNDLMGYQ
OrthoDBiEOG091G0LT1
PhylomeDBiQ5XIF3
TreeFamiTF105619

Family and domain databases

Gene3Di3.30.160.190, 1 hit
InterProiView protein in InterPro
IPR006885 NADH_UbQ_FeS_4_mit
IPR038532 NDUFS4-like_sf
PANTHERiPTHR12219 PTHR12219, 1 hit
PfamiView protein in Pfam
PF04800 ETC_C1_NDUFA4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSMSVSL RQALLRQRAV ATAAVSVCRV PSRLLNTSTW KLADGQTRDT
60 70 80 90 100
QLITVDEKLD VTPLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME
110 120 130 140 150
FDTRERWENP LMGWASTADP LSNMVLTFSA KEDAVAFAEK HGWSYDVEGR
160 170
KVPKPKSKSY GANFSWNKRT RVSTK
Length:175
Mass (Da):19,741
Last modified:November 23, 2004 - v1
Checksum:i726A1E60A4C8C205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083729 mRNA Translation: AAH83729.1
BC127458 mRNA Translation: AAI27459.1
RefSeqiNP_001020317.1, NM_001025146.1
UniGeneiRn.203141

Genome annotation databases

EnsembliENSRNOT00000015217; ENSRNOP00000015217; ENSRNOG00000011383
GeneIDi499529
KEGGirno:499529

Similar proteinsi

Entry informationi

Entry nameiNDUS4_RAT
AccessioniPrimary (citable) accession number: Q5XIF3
Secondary accession number(s): A1L111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health