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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

Ndufs4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Alternative name(s):
Complex I-18 kDa
Short name:
CI-18 kDa
NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene namesi
Name:Ndufs4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1594380. Ndufs4.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: Ensembl
  • mitochondrion Source: RGD
  • respiratory chain complex I Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionBy similarityAdd
BLAST
Chaini43 – 175133NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialPRO_0000250709Add
BLAST

Proteomic databases

PaxDbiQ5XIF3.
PRIDEiQ5XIF3.

PTM databases

iPTMnetiQ5XIF3.
SwissPalmiQ5XIF3.

Expressioni

Gene expression databases

GenevisibleiQ5XIF3. RN.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015217.

Structurei

3D structure databases

ProteinModelPortaliQ5XIF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3389. Eukaryota.
ENOG4111TR4. LUCA.
GeneTreeiENSGT00390000013835.
HOGENOMiHOG000140414.
HOVERGENiHBG003007.
InParanoidiQ5XIF3.
KOiK03937.
OMAiCEKNRWE.
OrthoDBiEOG7Z3F5X.
PhylomeDBiQ5XIF3.
TreeFamiTF105619.

Family and domain databases

InterProiIPR006885. NADH_UbQ_FeS_4_mit.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
PfamiPF04800. ETC_C1_NDUFA4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSMSVSL RQALLRQRAV ATAAVSVCRV PSRLLNTSTW KLADGQTRDT
60 70 80 90 100
QLITVDEKLD VTPLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME
110 120 130 140 150
FDTRERWENP LMGWASTADP LSNMVLTFSA KEDAVAFAEK HGWSYDVEGR
160 170
KVPKPKSKSY GANFSWNKRT RVSTK
Length:175
Mass (Da):19,741
Last modified:November 23, 2004 - v1
Checksum:i726A1E60A4C8C205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083729 mRNA. Translation: AAH83729.1.
BC127458 mRNA. Translation: AAI27459.1.
RefSeqiNP_001020317.1. NM_001025146.1.
UniGeneiRn.203141.

Genome annotation databases

EnsembliENSRNOT00000015217; ENSRNOP00000015217; ENSRNOG00000011383.
GeneIDi499529.
KEGGirno:499529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083729 mRNA. Translation: AAH83729.1.
BC127458 mRNA. Translation: AAI27459.1.
RefSeqiNP_001020317.1. NM_001025146.1.
UniGeneiRn.203141.

3D structure databases

ProteinModelPortaliQ5XIF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015217.

PTM databases

iPTMnetiQ5XIF3.
SwissPalmiQ5XIF3.

Proteomic databases

PaxDbiQ5XIF3.
PRIDEiQ5XIF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015217; ENSRNOP00000015217; ENSRNOG00000011383.
GeneIDi499529.
KEGGirno:499529.

Organism-specific databases

CTDi4724.
RGDi1594380. Ndufs4.

Phylogenomic databases

eggNOGiKOG3389. Eukaryota.
ENOG4111TR4. LUCA.
GeneTreeiENSGT00390000013835.
HOGENOMiHOG000140414.
HOVERGENiHBG003007.
InParanoidiQ5XIF3.
KOiK03937.
OMAiCEKNRWE.
OrthoDBiEOG7Z3F5X.
PhylomeDBiQ5XIF3.
TreeFamiTF105619.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ5XIF3.

Gene expression databases

GenevisibleiQ5XIF3. RN.

Family and domain databases

InterProiIPR006885. NADH_UbQ_FeS_4_mit.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
PfamiPF04800. ETC_C1_NDUFA4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 49-58, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiNDUS4_RAT
AccessioniPrimary (citable) accession number: Q5XIF3
Secondary accession number(s): A1L111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.