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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member E

Gene

Anp32e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Chromatin regulator

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member E
Gene namesi
Name:Anp32e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1310611. Anp32e.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Acidic leucine-rich nuclear phosphoprotein 32 family member EPRO_0000236251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Post-translational modificationi

Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XIE0.
PRIDEiQ5XIE0.

PTM databases

iPTMnetiQ5XIE0.
PhosphoSiteiQ5XIE0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021168.
GenevisibleiQ5XIE0. RN.

Interactioni

Subunit structurei

Component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 and ANP32E; the complex does not contain SRCAP. Interacts with H2A.Z/H2AFZ. Interacts with the importin alpha KPNA1 and KPNA2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi263117. 2 interactions.
STRINGi10116.ENSRNOP00000028744.

Structurei

3D structure databases

ProteinModelPortaliQ5XIE0.
SMRiQ5XIE0. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 3821LRR 1Add
BLAST
Repeati43 – 6422LRR 2Add
BLAST
Repeati65 – 8723LRR 3Add
BLAST
Repeati89 – 11022LRR 4Add
BLAST
Domaini123 – 16139LRRCTAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 25854ZID domainBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi151 – 258108Asp/Glu-rich (highly acidic)Add
BLAST

Domaini

The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ.By similarity

Sequence similaritiesi

Belongs to the ANP32 family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
GeneTreeiENSGT00560000077130.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiQ5XIE0.
KOiK18648.
OMAiRCPNLTY.
OrthoDBiEOG091G0R8Z.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMKKKINME LKNRAPEEVT ELVLDNCLCV NGEIEGLNDT FKELEFLSMA
60 70 80 90 100
NVELSSLARL PSLNKLRKLE LSDNIISGGL EVLAEKCPNL TYLNLSGNKI
110 120 130 140 150
KDLSTVEALQ NLKNLKSLDL FNCEITNLED YRESIFELLQ QITYLDGFDQ
160 170 180 190 200
EDNEAPDSEE EEEDEDGDED EEDEEEDEAG PPEGYEDEDE DEDEAGSEVG
210 220 230 240 250
EGEEEVGLSY LMKEEIQDEE DDDDYVDEGE EEEEEEEEGP RGEKRKRDAE

DDGEEDDD
Length:258
Mass (Da):29,418
Last modified:November 23, 2004 - v1
Checksum:i2312700EA7157B37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083744 mRNA. Translation: AAH83744.1.
RefSeqiNP_001013218.1. NM_001013200.1.
UniGeneiRn.4268.

Genome annotation databases

EnsembliENSRNOT00000028744; ENSRNOP00000028744; ENSRNOG00000021168.
GeneIDi361999.
KEGGirno:361999.
UCSCiRGD:1310611. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083744 mRNA. Translation: AAH83744.1.
RefSeqiNP_001013218.1. NM_001013200.1.
UniGeneiRn.4268.

3D structure databases

ProteinModelPortaliQ5XIE0.
SMRiQ5XIE0. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263117. 2 interactions.
STRINGi10116.ENSRNOP00000028744.

PTM databases

iPTMnetiQ5XIE0.
PhosphoSiteiQ5XIE0.

Proteomic databases

PaxDbiQ5XIE0.
PRIDEiQ5XIE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028744; ENSRNOP00000028744; ENSRNOG00000021168.
GeneIDi361999.
KEGGirno:361999.
UCSCiRGD:1310611. rat.

Organism-specific databases

CTDi81611.
RGDi1310611. Anp32e.

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
GeneTreeiENSGT00560000077130.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiQ5XIE0.
KOiK18648.
OMAiRCPNLTY.
OrthoDBiEOG091G0R8Z.

Miscellaneous databases

PROiQ5XIE0.

Gene expression databases

BgeeiENSRNOG00000021168.
GenevisibleiQ5XIE0. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN32E_RAT
AccessioniPrimary (citable) accession number: Q5XIE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.