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Protein

Armadillo repeat-containing X-linked protein 3

Gene

Armcx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2. Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1. Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 3
Gene namesi
Name:Armcx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1549739. Armcx3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneBy similarity6
Transmembranei7 – 29Helical; Signal-anchorSequence analysisAdd BLAST23
Topological domaini30 – 379CytoplasmicBy similarityAdd BLAST350

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913691 – 379Armadillo repeat-containing X-linked protein 3Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei110PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XID7.
PRIDEiQ5XID7.

PTM databases

iPTMnetiQ5XID7.
PhosphoSitePlusiQ5XID7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025730.
ExpressionAtlasiQ5XID7. baseline and differential.
GenevisibleiQ5XID7. RN.

Interactioni

Subunit structurei

Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent. Interacts with Sox10.By similarity

Protein-protein interaction databases

BioGridi266720. 1 interactor.
STRINGi10116.ENSRNOP00000033859.

Structurei

3D structure databases

ProteinModelPortaliQ5XID7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 151ARM 1Sequence analysisAdd BLAST41
Repeati153 – 192ARM 2Sequence analysisAdd BLAST40
Repeati233 – 272ARM 3Sequence analysisAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 6Mitochondrion outer membrane (MOM)-targeting sequenceCurated6
Regioni26 – 37Mitochondrion outer membrane (MOM)-targeting sequenceCuratedAdd BLAST12
Regioni89 – 98Nuclear localization signalBy similarity10

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ5XID7.
PhylomeDBiQ5XID7.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XID7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGPGDVEDAG
60 70 80 90 100
DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR
110 120 130 140 150
ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA
160 170 180 190 200
AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL
210 220 230 240 250
KIYMNQVCDD TVTSRLNSSV QLAGLRLLTN MTVTNEYQHI LANSISDFFR
260 270 280 290 300
LFSAGNEETK LQVLKLLLNL AENPAMTREL LGAHVPSSLG SLFNKKEYKE
310 320 330 340 350
VILKLLSIFE NINDNFKWEE NEPAQNHFSE GSLFFFLKEF QVCADKVLGI
360 370
ESHHDFQVRV KVGKFVTKLT ERMFPKSQE
Length:379
Mass (Da):42,553
Last modified:November 23, 2004 - v1
Checksum:iE4EA20CAAF376842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083747 mRNA. Translation: AAH83747.1.
RefSeqiNP_001014295.1. NM_001014273.1.
UniGeneiRn.44741.

Genome annotation databases

EnsembliENSRNOT00000029664; ENSRNOP00000033859; ENSRNOG00000025730.
GeneIDi367902.
KEGGirno:367902.
UCSCiRGD:1549739. rat.

Similar proteinsi

Entry informationi

Entry nameiARMX3_RAT
AccessioniPrimary (citable) accession number: Q5XID7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families