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Protein

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Gene

Ecsit

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.1 Publication
Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-RNO-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Gene namesi
Name:Ecsit
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1359488. Ecsit.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4848MitochondrionSequence analysisAdd
BLAST
Chaini49 – 434386Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialPRO_0000291988Add
BLAST

Proteomic databases

PaxDbiQ5XIC2.
PRIDEiQ5XIC2.

PTM databases

iPTMnetiQ5XIC2.

Expressioni

Gene expression databases

GenevisibleiQ5XIC2. RN.

Interactioni

Subunit structurei

Interacts with MAP3K1, NDUFAF1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9. Interacts with ACAD9. Interacts with TRIM59 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019115.

Family & Domainsi

Sequence similaritiesi

Belongs to the ECSIT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3941. Eukaryota.
ENOG41100I6. LUCA.
GeneTreeiENSGT00390000005147.
HOGENOMiHOG000112324.
HOVERGENiHBG059532.
InParanoidiQ5XIC2.
KOiK04405.
OMAiLRDKCVY.
OrthoDBiEOG76T9RM.
PhylomeDBiQ5XIC2.
TreeFamiTF314943.

Family and domain databases

InterProiIPR029342. ECIST_C.
IPR010418. ECSIT.
[Graphical view]
PANTHERiPTHR13113. PTHR13113. 1 hit.
PfamiPF14784. ECIST_C. 1 hit.
PF06239. ECSIT. 1 hit.
[Graphical view]
SMARTiSM01284. ECSIT_Cterm. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWVQVNLLA RGLSRGWGSI CRTVLSGTPF AQPSLQARGL HCSAVTHKDD
60 70 80 90 100
VWLVPRPSEP QKKPIKVPAM HEDLFRPSGN GEQDKASFLN AVRSFGEHNV
110 120 130 140 150
RKRGHVDFIY LALRKMPEFG VERDLSVYNL LLDVFPKEVF RPRNAIQRIF
160 170 180 190 200
VHYPRQQECG VAVLEQMERH GVMPNTETEF LLIQVFGHKS YPMLKFLRMK
210 220 230 240 250
LWFTRFKNIN PYPVPRDLPQ DPLDLAKLGL RHMEPDLSAK VTVYQMSLPS
260 270 280 290 300
ESTGIEDPTQ PHIVGIQSPD QQAALARHNP SRPVFVEGPF PLWLRNKCVY
310 320 330 340 350
YHILRADLPP PEEETVEEIP EEWNLYYPMQ LDLEYSRSAW DNYEFDMDEV
360 370 380 390 400
TEGPVFAMCM TGAHDQATLV KWIQGLQETN PTLAQIPVVF RLARSTGELL
410 420 430
ATTRLEGQSP PHSPPKGPEE DDEAIQAQQR QGQS
Length:434
Mass (Da):49,620
Last modified:November 23, 2004 - v1
Checksum:i04B3DEEEE8072319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083762 mRNA. Translation: AAH83762.1.
RefSeqiNP_001006987.1. NM_001006986.1.
XP_006242700.1. XM_006242638.2.
UniGeneiRn.8455.

Genome annotation databases

EnsembliENSRNOT00000019115; ENSRNOP00000019115; ENSRNOG00000014128.
GeneIDi300447.
KEGGirno:300447.
UCSCiRGD:1359488. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083762 mRNA. Translation: AAH83762.1.
RefSeqiNP_001006987.1. NM_001006986.1.
XP_006242700.1. XM_006242638.2.
UniGeneiRn.8455.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019115.

PTM databases

iPTMnetiQ5XIC2.

Proteomic databases

PaxDbiQ5XIC2.
PRIDEiQ5XIC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019115; ENSRNOP00000019115; ENSRNOG00000014128.
GeneIDi300447.
KEGGirno:300447.
UCSCiRGD:1359488. rat.

Organism-specific databases

CTDi51295.
RGDi1359488. Ecsit.

Phylogenomic databases

eggNOGiKOG3941. Eukaryota.
ENOG41100I6. LUCA.
GeneTreeiENSGT00390000005147.
HOGENOMiHOG000112324.
HOVERGENiHBG059532.
InParanoidiQ5XIC2.
KOiK04405.
OMAiLRDKCVY.
OrthoDBiEOG76T9RM.
PhylomeDBiQ5XIC2.
TreeFamiTF314943.

Enzyme and pathway databases

ReactomeiR-RNO-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ5XIC2.

Gene expression databases

GenevisibleiQ5XIC2. RN.

Family and domain databases

InterProiIPR029342. ECIST_C.
IPR010418. ECSIT.
[Graphical view]
PANTHERiPTHR13113. PTHR13113. 1 hit.
PfamiPF14784. ECIST_C. 1 hit.
PF06239. ECSIT. 1 hit.
[Graphical view]
SMARTiSM01284. ECSIT_Cterm. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex."
    Heide H., Bleier L., Steger M., Ackermann J., Drose S., Schwamb B., Zornig M., Reichert A.S., Koch I., Wittig I., Brandt U.
    Cell Metab. 16:538-549(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MCIA COMPLEX, FUNCTION.

Entry informationi

Entry nameiECSIT_RAT
AccessioniPrimary (citable) accession number: Q5XIC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.