Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Gene

Ecsit

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.1 Publication
Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-RNO-166058 MyD88:Mal cascade initiated on plasma membrane
R-RNO-6799198 Complex I biogenesis
R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-RNO-975871 MyD88 cascade initiated on plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Gene namesi
Name:Ecsit
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1359488 Ecsit

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48MitochondrionSequence analysisAdd BLAST48
ChainiPRO_000029198849 – 434Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialAdd BLAST386

Proteomic databases

PaxDbiQ5XIC2
PRIDEiQ5XIC2

PTM databases

iPTMnetiQ5XIC2
PhosphoSitePlusiQ5XIC2

Expressioni

Gene expression databases

BgeeiENSRNOG00000014128
GenevisibleiQ5XIC2 RN

Interactioni

Subunit structurei

Interacts with MAP3K1, NDUFAF1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9. Interacts with ACAD9. Interacts with TRIM59 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019115

Family & Domainsi

Sequence similaritiesi

Belongs to the ECSIT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3941 Eukaryota
ENOG41100I6 LUCA
GeneTreeiENSGT00390000005147
HOGENOMiHOG000112324
HOVERGENiHBG059532
InParanoidiQ5XIC2
KOiK04405
OMAiINVMPKG
OrthoDBiEOG091G07N5
PhylomeDBiQ5XIC2
TreeFamiTF314943

Family and domain databases

InterProiView protein in InterPro
IPR029342 ECIST_C
IPR010418 ECSIT
PANTHERiPTHR13113 PTHR13113, 1 hit
PfamiView protein in Pfam
PF06239 ECSIT, 1 hit
PF14784 ECSIT_C, 1 hit
SMARTiView protein in SMART
SM01284 ECSIT_Cterm, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWVQVNLLA RGLSRGWGSI CRTVLSGTPF AQPSLQARGL HCSAVTHKDD
60 70 80 90 100
VWLVPRPSEP QKKPIKVPAM HEDLFRPSGN GEQDKASFLN AVRSFGEHNV
110 120 130 140 150
RKRGHVDFIY LALRKMPEFG VERDLSVYNL LLDVFPKEVF RPRNAIQRIF
160 170 180 190 200
VHYPRQQECG VAVLEQMERH GVMPNTETEF LLIQVFGHKS YPMLKFLRMK
210 220 230 240 250
LWFTRFKNIN PYPVPRDLPQ DPLDLAKLGL RHMEPDLSAK VTVYQMSLPS
260 270 280 290 300
ESTGIEDPTQ PHIVGIQSPD QQAALARHNP SRPVFVEGPF PLWLRNKCVY
310 320 330 340 350
YHILRADLPP PEEETVEEIP EEWNLYYPMQ LDLEYSRSAW DNYEFDMDEV
360 370 380 390 400
TEGPVFAMCM TGAHDQATLV KWIQGLQETN PTLAQIPVVF RLARSTGELL
410 420 430
ATTRLEGQSP PHSPPKGPEE DDEAIQAQQR QGQS
Length:434
Mass (Da):49,620
Last modified:November 23, 2004 - v1
Checksum:i04B3DEEEE8072319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083762 mRNA Translation: AAH83762.1
RefSeqiNP_001006987.1, NM_001006986.1
XP_006242700.1, XM_006242638.3
UniGeneiRn.8455

Genome annotation databases

EnsembliENSRNOT00000019115; ENSRNOP00000019115; ENSRNOG00000014128
GeneIDi300447
KEGGirno:300447
UCSCiRGD:1359488 rat

Similar proteinsi

Entry informationi

Entry nameiECSIT_RAT
AccessioniPrimary (citable) accession number: Q5XIC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health