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Protein

Mannose-1-phosphate guanyltransferase alpha

Gene

Gmppa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-446205. Synthesis of GDP-mannose.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase alpha
Alternative name(s):
GDP-mannose pyrophosphorylase A
GTP-mannose-1-phosphate guanylyltransferase alpha
Gene namesi
Name:Gmppa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1560644. Gmppa.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278751 – 420Mannose-1-phosphate guanyltransferase alphaAdd BLAST420

Proteomic databases

PaxDbiQ5XIC1.
PRIDEiQ5XIC1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019946.
ExpressionAtlasiQ5XIC1. baseline and differential.
GenevisibleiQ5XIC1. RN.

Interactioni

Subunit structurei

Associates with GMPPB.By similarity

Protein-protein interaction databases

BioGridi272474. 1 interactor.
STRINGi10116.ENSRNOP00000027064.

Structurei

3D structure databases

ProteinModelPortaliQ5XIC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1460. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
HOVERGENiHBG059531.
InParanoidiQ5XIC1.
KOiK00966.
PhylomeDBiQ5XIC1.
TreeFamiTF300832.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM
60 70 80 90 100
QEILLIGFYQ PDEALTQFLE AAQQEFNLPV RYLQEFTPLG TGGGLYHFRD
110 120 130 140 150
QILAGAPEAF FVLNADVCSD FPLSAMLDAH RLQRHPFLLL GTTANRTQSL
160 170 180 190 200
NYGCIVENPQ THEVLHYVEK PSTFISDIIN CGIYLFSPEA LKPLRDVFQR
210 220 230 240 250
NQQDGQLEES PGSWPGAGTI RLEQDVFSAL AGQGQIYVHL TDGIWSQIKS
260 270 280 290 300
AGSALYASRL YLGRYQITHP ERLARHTAGG PRIRGNVYIH PTAKVAPSAV
310 320 330 340 350
LGPNVSIGKG VTIGEGVRLR ESIVLHGATL QEHTCVLHSI VGWGSTVGRW
360 370 380 390 400
ARVEGTPNDP NPNDPRARMD SESLFKDGKL LPAITILGCR VRIPAEVLIL
410 420
NSIVLPHKEL SRSFTNQIIL
Length:420
Mass (Da):46,191
Last modified:November 23, 2004 - v1
Checksum:i4433A234E92BA083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083763 mRNA. Translation: AAH83763.1.
RefSeqiNP_001020227.1. NM_001025056.1.
XP_006245333.1. XM_006245271.2.
UniGeneiRn.7577.

Genome annotation databases

EnsembliENSRNOT00000027064; ENSRNOP00000027064; ENSRNOG00000019946.
GeneIDi501167.
KEGGirno:501167.
UCSCiRGD:1560644. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083763 mRNA. Translation: AAH83763.1.
RefSeqiNP_001020227.1. NM_001025056.1.
XP_006245333.1. XM_006245271.2.
UniGeneiRn.7577.

3D structure databases

ProteinModelPortaliQ5XIC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi272474. 1 interactor.
STRINGi10116.ENSRNOP00000027064.

Proteomic databases

PaxDbiQ5XIC1.
PRIDEiQ5XIC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027064; ENSRNOP00000027064; ENSRNOG00000019946.
GeneIDi501167.
KEGGirno:501167.
UCSCiRGD:1560644. rat.

Organism-specific databases

CTDi29926.
RGDi1560644. Gmppa.

Phylogenomic databases

eggNOGiKOG1460. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
HOVERGENiHBG059531.
InParanoidiQ5XIC1.
KOiK00966.
PhylomeDBiQ5XIC1.
TreeFamiTF300832.

Enzyme and pathway databases

ReactomeiR-RNO-446205. Synthesis of GDP-mannose.

Miscellaneous databases

PROiQ5XIC1.

Gene expression databases

BgeeiENSRNOG00000019946.
ExpressionAtlasiQ5XIC1. baseline and differential.
GenevisibleiQ5XIC1. RN.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMPPA_RAT
AccessioniPrimary (citable) accession number: Q5XIC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.