Q5XIC1 (GMPPA_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase alpha
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase A
GTP-mannose-1-phosphate guanylyltransferase alpha

Gene names

Name:

Gmppa

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Mannose-1-phosphate guanyltransferase alpha		PRO_0000327875

Sequences

	Sequence		Length	Mass (Da)
	Q5XIC1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 4433A234E92BA083	FASTA	420	46,191
	10 20 30 40 50 60 MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM QEILLIGFYQ 70 80 90 100 110 120 PDEALTQFLE AAQQEFNLPV RYLQEFTPLG TGGGLYHFRD QILAGAPEAF FVLNADVCSD 130 140 150 160 170 180 FPLSAMLDAH RLQRHPFLLL GTTANRTQSL NYGCIVENPQ THEVLHYVEK PSTFISDIIN 190 200 210 220 230 240 CGIYLFSPEA LKPLRDVFQR NQQDGQLEES PGSWPGAGTI RLEQDVFSAL AGQGQIYVHL 250 260 270 280 290 300 TDGIWSQIKS AGSALYASRL YLGRYQITHP ERLARHTAGG PRIRGNVYIH PTAKVAPSAV 310 320 330 340 350 360 LGPNVSIGKG VTIGEGVRLR ESIVLHGATL QEHTCVLHSI VGWGSTVGRW ARVEGTPNDP 370 380 390 400 410 420 NPNDPRARMD SESLFKDGKL LPAITILGCR VRIPAEVLIL NSIVLPHKEL SRSFTNQIIL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC083763 mRNA. Translation: AAH83763.1.
IPI	IPI00197993.
RefSeq	NP_001020227.1. NM_001025056.1.
UniGene	Rn.7577.
3D structure databases
ProteinModelPortal	Q5XIC1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5XIC1.
Proteomic databases
PRIDE	Q5XIC1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000027064; ENSRNOP00000027064; ENSRNOG00000019946.
GeneID	501167.
KEGG	rno:501167.
NMPDR	fig|10116.3.peg.30290.
UCSC	NM_001025056. rat.
Organism-specific databases
CTD	29926.
RGD	1560644. Gmppa.
Phylogenomic databases
eggNOG	roNOG13498.
GeneTree	ENSGT00530000063581.
HOVERGEN	HBG059531.
InParanoid	Q5XIC1.
OMA	PFAKMDN.
OrthoDB	EOG4SXNCG.
PhylomeDB	Q5XIC1.
Gene expression databases
ArrayExpress	Q5XIC1.
Genevestigator	Q5XIC1.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	708497.

Entry information

Entry name

GMPPA_RAT

Accession

Primary (citable) accession number: Q5XIC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program