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Protein

Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Gene

Cwc27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CWC27 homolog (EC:5.2.1.8)
Short name:
PPIase CWC27
Gene namesi
Name:Cwc27
Synonyms:Sdccag10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1310697. Cwc27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 468467Peptidyl-prolyl cis-trans isomerase CWC27 homologPRO_0000313651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei273 – 2731PhosphoserineCombined sources
Modified residuei343 – 3431PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XIB2.
PRIDEiQ5XIB2.

PTM databases

iPTMnetiQ5XIB2.

Expressioni

Gene expression databases

ExpressionAtlasiQ5XIB2. baseline and differential.
GenevisibleiQ5XIB2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017832.

Structurei

3D structure databases

ProteinModelPortaliQ5XIB2.
SMRiQ5XIB2. Positions 8-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 166156PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili206 – 22924Sequence analysisAdd
BLAST
Coiled coili309 – 34234Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0885. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOVERGENiHBG097993.
InParanoidiQ5XIB2.
KOiK12737.
OMAiANMQDED.
OrthoDBiEOG7353XC.
PhylomeDBiQ5XIB2.
TreeFamiTF105935.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGTGGESVYG APFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLTEVDID
160 170 180 190 200
DEERPRNPHR IKSCEVLFNP FDDIIPREIK KPKKEKAEEE IKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGRSK SSHDLLKDDP HLSSVPAVES
260 270 280 290 300
EKDDATGDLE DDAEDDSVEH DGSMEEDEKN LMRERIAKRL KKDASANVKS
310 320 330 340 350
AGDGEKKPAS RSEELRKEAR QLKRELLAAK QKKESATKAE KGSEEEEAVP
360 370 380 390 400
DGPVAEYRRE KQKYEALRKQ QPKKGTSRED QTLALLSQFK SKLTQAITEM
410 420 430 440 450
PENCAEAEVE DDEGWMSHVL QFEDKTRKVK DASMQDSDTF EIYDPRNPVN
460
KRRREESKKL LREKKERR
Length:468
Mass (Da):53,310
Last modified:November 23, 2004 - v1
Checksum:i6F2D09A03E81E725
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083774 mRNA. Translation: AAH83774.1.
RefSeqiNP_001013217.1. NM_001013199.1.
UniGeneiRn.153577.

Genome annotation databases

EnsembliENSRNOT00000017832; ENSRNOP00000017832; ENSRNOG00000013252.
GeneIDi361887.
KEGGirno:361887.
UCSCiRGD:1310697. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083774 mRNA. Translation: AAH83774.1.
RefSeqiNP_001013217.1. NM_001013199.1.
UniGeneiRn.153577.

3D structure databases

ProteinModelPortaliQ5XIB2.
SMRiQ5XIB2. Positions 8-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017832.

PTM databases

iPTMnetiQ5XIB2.

Proteomic databases

PaxDbiQ5XIB2.
PRIDEiQ5XIB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017832; ENSRNOP00000017832; ENSRNOG00000013252.
GeneIDi361887.
KEGGirno:361887.
UCSCiRGD:1310697. rat.

Organism-specific databases

CTDi10283.
RGDi1310697. Cwc27.

Phylogenomic databases

eggNOGiKOG0885. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOVERGENiHBG097993.
InParanoidiQ5XIB2.
KOiK12737.
OMAiANMQDED.
OrthoDBiEOG7353XC.
PhylomeDBiQ5XIB2.
TreeFamiTF105935.

Miscellaneous databases

PROiQ5XIB2.

Gene expression databases

ExpressionAtlasiQ5XIB2. baseline and differential.
GenevisibleiQ5XIB2. RN.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCWC27_RAT
AccessioniPrimary (citable) accession number: Q5XIB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.