ID   Q5XIB0_RAT              Unreviewed;       421 AA.
AC   Q5XIB0;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 162.
DE   SubName: Full=Interferon regulatory factor 3 {ECO:0000313|EMBL:AAH83776.1, ECO:0000313|EMBL:EDM07431.1};
GN   Name=Irf3 {ECO:0000313|EMBL:AAH83776.1, ECO:0000313|RGD:1549774};
GN   ORFNames=rCG_54412 {ECO:0000313|EMBL:EDM07431.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH83776.1};
RN   [1] {ECO:0000313|EMBL:AAH83776.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart {ECO:0000313|EMBL:AAH83776.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|EMBL:EDM07431.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM07431.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDM07431.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM07431.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F.,
RA   Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G.,
RA   Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC083776; AAH83776.1; -; mRNA.
DR   EMBL; CH473979; EDM07431.1; -; Genomic_DNA.
DR   EMBL; CH473979; EDM07432.1; -; Genomic_DNA.
DR   RefSeq; NP_001006970.1; NM_001006969.1.
DR   RefSeq; XP_006229085.1; XM_006229023.2.
DR   RefSeq; XP_006229086.1; XM_006229024.2.
DR   AlphaFoldDB; Q5XIB0; -.
DR   SMR; Q5XIB0; -.
DR   STRING; 10116.ENSRNOP00000027786; -.
DR   PhosphoSitePlus; Q5XIB0; -.
DR   PaxDb; 10116-ENSRNOP00000027786; -.
DR   GeneID; 292892; -.
DR   KEGG; rno:292892; -.
DR   AGR; RGD:1549774; -.
DR   CTD; 3661; -.
DR   RGD; 1549774; Irf3.
DR   VEuPathDB; HostDB:ENSRNOG00000043388; -.
DR   eggNOG; ENOG502QTRR; Eukaryota.
DR   HOGENOM; CLU_031544_2_0_1; -.
DR   OrthoDB; 3740806at2759; -.
DR   TreeFam; TF328512; -.
DR   Reactome; R-RNO-1169408; ISG15 antiviral mechanism.
DR   Reactome; R-RNO-1606341; IRF3 mediated activation of type 1 IFN.
DR   Reactome; R-RNO-168928; DDX58/IFIH1-mediated induction of interferon-alpha/beta.
DR   Reactome; R-RNO-3134973; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
DR   Reactome; R-RNO-3134975; Regulation of innate immune responses to cytosolic DNA.
DR   Reactome; R-RNO-3270619; IRF3-mediated induction of type I IFN.
DR   Reactome; R-RNO-9013973; TICAM1-dependent activation of IRF3/IRF7.
DR   Reactome; R-RNO-918233; TRAF3-dependent IRF activation pathway.
DR   Reactome; R-RNO-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-RNO-936440; Negative regulators of DDX58/IFIH1 signaling.
DR   Reactome; R-RNO-936964; Activation of IRF3, IRF7 mediated by TBK1, IKBKE.
DR   Proteomes; UP000234681; Chromosome 1.
DR   Bgee; ENSRNOG00000043388; Expressed in thymus and 20 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISO:RGD.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0071360; P:cellular response to exogenous dsRNA; IEP:RGD.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
DR   GO; GO:0098586; P:cellular response to virus; ISO:RGD.
DR   GO; GO:0002753; P:cytoplasmic pattern recognition receptor signaling pathway; ISO:RGD.
DR   GO; GO:0051607; P:defense response to virus; ISO:RGD.
DR   GO; GO:0002376; P:immune system process; IBA:GO_Central.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IMP:RGD.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IMP:RGD.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:RGD.
DR   GO; GO:0032727; P:positive regulation of interferon-alpha production; ISO:RGD.
DR   GO; GO:0032728; P:positive regulation of interferon-beta production; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0032481; P:positive regulation of type I interferon production; ISO:RGD.
DR   GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0097300; P:programmed necrotic cell death; ISO:RGD.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR   GO; GO:0043330; P:response to exogenous dsRNA; ISO:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; ISO:RGD.
DR   GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; ISO:RGD.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; ISO:RGD.
DR   CDD; cd00103; IRF; 1.
DR   Gene3D; 2.60.200.10; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR019817; Interferon_reg_fac_CS.
DR   InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR   InterPro; IPR019471; Interferon_reg_factor-3.
DR   InterPro; IPR017855; SMAD-like_dom_sf.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR   PANTHER; PTHR11949:SF1; INTERFERON REGULATORY FACTOR 3; 1.
DR   Pfam; PF00605; IRF; 1.
DR   Pfam; PF10401; IRF-3; 1.
DR   PRINTS; PR00267; INTFRNREGFCT.
DR   SMART; SM00348; IRF; 1.
DR   SMART; SM01243; IRF-3; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00601; IRF_1; 1.
DR   PROSITE; PS51507; IRF_2; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          5..111
FT                   /note="IRF tryptophan pentad repeat"
FT                   /evidence="ECO:0000259|PROSITE:PS51507"
SQ   SEQUENCE   421 AA;  47279 MW;  4ECD3290804EF09F CRC64;
     MGTPKPLILP WLVSQLDLGQ LKGVAWLDES RTKFRIPWKH GLRQDAQMAD FGIFQAWAEA
     SGAYTPGKDK PDLSTWKRNF RSALNRKEVL RLAEDRSKDP FDPHKVYEFV TPGGARDFVH
     LDTSPDTNGK SSLSDHQEDL LELLDHMALG PLPDEGSSDL PIASDPSQPP LSPIVNNFPN
     PAPQENPLRQ LLAEEQWEFE VTAFYRGRQV FQQTLFCPGG LRLVGSTSDN GTLPWQPVTL
     PDPEEFLTDR LVREYVRQVL KGLGKGLVLW RAGQCLWAQR LGHSHSFWAL GEELLPDSGR
     GPDGEVPKDK NGVVFDLRPF VADLIAFMEG SRHSPRYTLW FCVGESWPQD QPWVKRLVMV
     KVVPTCLKEL LEMAREGGAS SLKTVDLHIS NSQPISLTSD QYKACLQDLV EDMDFQATGE
     T
//