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Protein

Kelch domain-containing protein 8B

Gene

Klhdc8b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 8B
Gene namesi
Name:Klhdc8b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1359445. Klhdc8b.

Subcellular locationi

  • Cytoplasm

  • Note: In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Kelch domain-containing protein 8BPRO_0000119134Add
BLAST

Proteomic databases

PaxDbiQ5XIA9.

Expressioni

Gene expression databases

GenevisibleiQ5XIA9. RN.

Structurei

3D structure databases

ProteinModelPortaliQ5XIA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 3131Kelch 1Add
BLAST
Repeati32 – 7948Kelch 2Add
BLAST
Repeati81 – 12747Kelch 3Add
BLAST
Repeati128 – 17548Kelch 4Add
BLAST
Repeati176 – 22247Kelch 5Add
BLAST
Repeati224 – 28158Kelch 6Add
BLAST
Repeati282 – 32948Kelch 7Add
BLAST
Repeati331 – 35424Kelch 8Add
BLAST

Sequence similaritiesi

Contains 8 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000119153.
HOVERGENiHBG055245.
InParanoidiQ5XIA9.
OMAiNQPCPLA.
OrthoDBiEOG7W41C3.
PhylomeDBiQ5XIA9.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 4 hits.
[Graphical view]
SMARTiSM00612. Kelch. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGGGQAFA WQVFPPMPTC RVYGTVAHQD GHLLVLGGCG RAGLPLDTAE
60 70 80 90 100
TLDMASHTWL ALAPLPTARA GAAAVVLGKQ VLVVGGVDEV QSPVAAVEAF
110 120 130 140 150
LADEGRWERR ATLPQAAMGV ATVERDGMVY ALGGMGPDTA PQAQVLVYES
160 170 180 190 200
RRDRWLSLPS MPTPCYGAST FLHGNKIYVL GGRQGKLPVT AFEAFDLETR
210 220 230 240 250
TWTRHPSLPS RRAFAGCAMA EGSVFSLGGL QQPGPHNFYS RPHFVNTVEM
260 270 280 290 300
FDLEHGSWTK LPRSLRMRDK RADFVVGSLG GNIVAIGGLG NQPCPLASVE
310 320 330 340 350
SFSLARRRWE ALPAMPTARC SCSSLQAGPR LFVIGGVAQG PSQAVEALCL

RDGV
Length:354
Mass (Da):37,593
Last modified:November 23, 2004 - v1
Checksum:i98A5EF3876ADA988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083777 mRNA. Translation: AAH83777.1.
RefSeqiNP_001007686.1. NM_001007685.1.
XP_008764738.1. XM_008766516.1.
XP_008764739.1. XM_008766517.1.
UniGeneiRn.41577.

Genome annotation databases

EnsembliENSRNOT00000071381; ENSRNOP00000066316; ENSRNOG00000047867.
GeneIDi306589.
KEGGirno:306589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083777 mRNA. Translation: AAH83777.1.
RefSeqiNP_001007686.1. NM_001007685.1.
XP_008764738.1. XM_008766516.1.
XP_008764739.1. XM_008766517.1.
UniGeneiRn.41577.

3D structure databases

ProteinModelPortaliQ5XIA9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ5XIA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071381; ENSRNOP00000066316; ENSRNOG00000047867.
GeneIDi306589.
KEGGirno:306589.

Organism-specific databases

CTDi200942.
RGDi1359445. Klhdc8b.

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000119153.
HOVERGENiHBG055245.
InParanoidiQ5XIA9.
OMAiNQPCPLA.
OrthoDBiEOG7W41C3.
PhylomeDBiQ5XIA9.

Miscellaneous databases

NextBioi656276.
PROiQ5XIA9.

Gene expression databases

GenevisibleiQ5XIA9. RN.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 4 hits.
[Graphical view]
SMARTiSM00612. Kelch. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiKLD8B_RAT
AccessioniPrimary (citable) accession number: Q5XIA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.