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Protein

Sphingomyelin phosphodiesterase

Gene

Smpd1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Converts sphingomyelin to ceramide.UniRule annotation

Catalytic activityi

Sphingomyelin + H2O = N-acylsphingosine + phosphocholine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • ceramide biosynthetic process Source: RGD
  • negative regulation of MAP kinase activity Source: Ensembl
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of protein dephosphorylation Source: Ensembl
  • response to cocaine Source: RGD
  • response to drug Source: RGD
  • sphingomyelin catabolic process Source: Ensembl
  • termination of signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-1660662. Glycosphingolipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingomyelin phosphodiesteraseUniRule annotation (EC:3.1.4.12UniRule annotation)
Gene namesi
Name:Smpd1Imported
ORF Names:rCG_39318Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1549719. Smpd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 53HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

  • endosome Source: Ensembl
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • lamellar body Source: RGD
  • lysosome Source: Ensembl
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000017977.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024224.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 167Saposin B-typeInterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the acid sphingomyelinase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3770. Eukaryota.
ENOG410YYPB. LUCA.
GeneTreeiENSGT00530000063095.
HOGENOMiHOG000008599.
HOVERGENiHBG004288.
KOiK12350.
OMAiFVIGDGC.
OrthoDBiEOG091G03M6.
TreeFamiTF313674.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHHGASSGQ GHLRAGWEQR LERSLPAPKL GLLWMGLGLA LVLALFDSTV
60 70 80 90 100
LWVPARAYPL PSQGHSVKFS AVAPQLQNAF GWRNLTCPAC KVLFTALNYG
110 120 130 140 150
LKKEPNVARV GSVAIKMCKM LNIAPLNVCQ SAVHLFEDDV VDVWTRSVLS
160 170 180 190 200
PSEACGLLLG SSCGHWDIFS TWNISLPSVP KPPPKPPSPP APGAPVSRVL
210 220 230 240 250
FLTDLHWDHD YLEGTDPNCA DPLCCRRGSG WPPNSRTGAG YWGEYSKCDL
260 270 280 290 300
PLRTLESLLK GLGPAGPFEM VYWTGDIPAH DVWQQSRQDQ LRALNTITDL
310 320 330 340 350
VWKFLGPVPV YPAVGNHEST PVNGFPPPFI KGNQSSQWLY EAMAKAWEPW
360 370 380 390 400
LPADALHTLR IGGFYALTPR PGLRLISLNM NFCSRENFWL LINSTDPAGQ
410 420 430 440 450
LQWLVDELQA AENRGDKVHI IGHIPPGHCL KSWSWNYYKI IARYENTLAG
460 470 480 490 500
QFFGHTHVDE FEIFYDEETL SRPLAVAFLG PSATTFINLN PGYRVYQIDG
510 520 530 540 550
NYPGSSHVVL DHETYILNLT QANAPGGTPS WKRLYRARET YGLPDAMPAS
560 570 580 590 600
WHNLVYRMRA DEQLFQTFWF LYHKGHPPSE PCGTPCRLAT LCAQLSARAD
610 620
SPALCRHLMP NGSLPDAHSL WSRPLLC
Length:627
Mass (Da):69,761
Last modified:November 23, 2004 - v1
Checksum:i2BE1585CF13F454C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097992 Genomic DNA. No translation available.
BC083780 mRNA. Translation: AAH83780.1.
CH473956 Genomic DNA. Translation: EDM18044.1.
RefSeqiNP_001006998.1. NM_001006997.1.
UniGeneiRn.18277.

Genome annotation databases

EnsembliENSRNOT00000024224; ENSRNOP00000024224; ENSRNOG00000017977.
GeneIDi308909.
KEGGirno:308909.
UCSCiRGD:1549719. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097992 Genomic DNA. No translation available.
BC083780 mRNA. Translation: AAH83780.1.
CH473956 Genomic DNA. Translation: EDM18044.1.
RefSeqiNP_001006998.1. NM_001006997.1.
UniGeneiRn.18277.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024224; ENSRNOP00000024224; ENSRNOG00000017977.
GeneIDi308909.
KEGGirno:308909.
UCSCiRGD:1549719. rat.

Organism-specific databases

CTDi6609.
RGDi1549719. Smpd1.

Phylogenomic databases

eggNOGiKOG3770. Eukaryota.
ENOG410YYPB. LUCA.
GeneTreeiENSGT00530000063095.
HOGENOMiHOG000008599.
HOVERGENiHBG004288.
KOiK12350.
OMAiFVIGDGC.
OrthoDBiEOG091G03M6.
TreeFamiTF313674.

Enzyme and pathway databases

ReactomeiR-RNO-1660662. Glycosphingolipid metabolism.

Miscellaneous databases

PROiQ5XIA6.

Gene expression databases

BgeeiENSRNOG00000017977.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5XIA6_RAT
AccessioniPrimary (citable) accession number: Q5XIA6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.