Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CCR4-NOT transcription complex subunit 10

Gene

Cnot10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 10
Gene namesi
Name:Cnot10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359219 Cnot10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003145822 – 744CCR4-NOT transcription complex subunit 10Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIA4
PRIDEiQ5XIA4

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013817

Structurei

3D structure databases

ProteinModelPortaliQ5XIA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNOT10 family.Curated

Phylogenomic databases

eggNOGiKOG2471 Eukaryota
ENOG410XQQJ LUCA
HOGENOMiHOG000111843
HOVERGENiHBG077464
InParanoidiQ5XIA4
KOiK12607
PhylomeDBiQ5XIA4
TreeFamiTF323368

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADKPADQG AEKHEGAGQS SGVTDQEKEL STSAFQAFTS GNYDACLQHL
60 70 80 90 100
ACLQDINKDD YKIILNTAVA EFFKNNQTTT DNLRQTLNQL KNQVHSAVEE
110 120 130 140 150
MDGLDDVENS MLYYNQAVIL YHLRQHTEAI AVGEKLYQFI EPFEEKFAQA
160 170 180 190 200
VCFLLVDLYI LTHQAEKALH LLAVLEKMIS QGSGNKNGKS ETGNNSSKDG
210 220 230 240 250
SNPKAESAAL IEAAKSKIHQ YKVRGYIQMK SLKACKREIK SVMNTAGNSA
260 270 280 290 300
PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
310 320 330 340 350
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGNTDPGKK FSGRPMCTLL
360 370 380 390 400
ANKRYELLYN CGIQLLHVGR PLAAFECLVE AVQVYHANPR LWLRLAECCI
410 420 430 440 450
AANKGTSEQE TKGLPTKKGI VQSIVGQGYH RKIVLASQSI QNTVYNDGQS
460 470 480 490 500
SAIPVASVEF AAICLRNALL LLPEEQQDPK QENGSKSSSQ LGGNAESSES
510 520 530 540 550
SETCSSKSHD GDKLIPAPPS SPLRKQELEN LKCSILACSA YVALALGDNL
560 570 580 590 600
MALNHADQLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
610 620 630 640 650
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG
660 670 680 690 700
SAYCLRSEYD KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL
710 720 730 740
QMIKRNQLLP AVKAHSDVRK KTVFQPVHPI QPIQMPAFTT VQRK
Length:744
Mass (Da):81,819
Last modified:November 23, 2004 - v1
Checksum:i3486682DB9C33F96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083782 mRNA Translation: AAH83782.1
RefSeqiNP_001007004.1, NM_001007003.1
UniGeneiRn.23825

Genome annotation databases

GeneIDi316034
KEGGirno:316034
UCSCiRGD:1359219 rat

Similar proteinsi

Entry informationi

Entry nameiCNO10_RAT
AccessioniPrimary (citable) accession number: Q5XIA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health