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Protein

CCR4-NOT transcription complex subunit 10

Gene

Cnot10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 10
Gene namesi
Name:Cnot10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359219. Cnot10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 744743CCR4-NOT transcription complex subunit 10PRO_0000314582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIA4.
PRIDEiQ5XIA4.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013817.

Structurei

3D structure databases

ProteinModelPortaliQ5XIA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNOT10 family.Curated

Phylogenomic databases

eggNOGiKOG2471. Eukaryota.
ENOG410XQQJ. LUCA.
HOGENOMiHOG000111843.
HOVERGENiHBG077464.
InParanoidiQ5XIA4.
KOiK12607.
PhylomeDBiQ5XIA4.
TreeFamiTF323368.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADKPADQG AEKHEGAGQS SGVTDQEKEL STSAFQAFTS GNYDACLQHL
60 70 80 90 100
ACLQDINKDD YKIILNTAVA EFFKNNQTTT DNLRQTLNQL KNQVHSAVEE
110 120 130 140 150
MDGLDDVENS MLYYNQAVIL YHLRQHTEAI AVGEKLYQFI EPFEEKFAQA
160 170 180 190 200
VCFLLVDLYI LTHQAEKALH LLAVLEKMIS QGSGNKNGKS ETGNNSSKDG
210 220 230 240 250
SNPKAESAAL IEAAKSKIHQ YKVRGYIQMK SLKACKREIK SVMNTAGNSA
260 270 280 290 300
PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
310 320 330 340 350
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGNTDPGKK FSGRPMCTLL
360 370 380 390 400
ANKRYELLYN CGIQLLHVGR PLAAFECLVE AVQVYHANPR LWLRLAECCI
410 420 430 440 450
AANKGTSEQE TKGLPTKKGI VQSIVGQGYH RKIVLASQSI QNTVYNDGQS
460 470 480 490 500
SAIPVASVEF AAICLRNALL LLPEEQQDPK QENGSKSSSQ LGGNAESSES
510 520 530 540 550
SETCSSKSHD GDKLIPAPPS SPLRKQELEN LKCSILACSA YVALALGDNL
560 570 580 590 600
MALNHADQLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
610 620 630 640 650
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG
660 670 680 690 700
SAYCLRSEYD KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL
710 720 730 740
QMIKRNQLLP AVKAHSDVRK KTVFQPVHPI QPIQMPAFTT VQRK
Length:744
Mass (Da):81,819
Last modified:November 23, 2004 - v1
Checksum:i3486682DB9C33F96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083782 mRNA. Translation: AAH83782.1.
RefSeqiNP_001007004.1. NM_001007003.1.
UniGeneiRn.23825.

Genome annotation databases

GeneIDi316034.
KEGGirno:316034.
UCSCiRGD:1359219. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083782 mRNA. Translation: AAH83782.1.
RefSeqiNP_001007004.1. NM_001007003.1.
UniGeneiRn.23825.

3D structure databases

ProteinModelPortaliQ5XIA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013817.

Proteomic databases

PaxDbiQ5XIA4.
PRIDEiQ5XIA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316034.
KEGGirno:316034.
UCSCiRGD:1359219. rat.

Organism-specific databases

CTDi25904.
RGDi1359219. Cnot10.

Phylogenomic databases

eggNOGiKOG2471. Eukaryota.
ENOG410XQQJ. LUCA.
HOGENOMiHOG000111843.
HOVERGENiHBG077464.
InParanoidiQ5XIA4.
KOiK12607.
PhylomeDBiQ5XIA4.
TreeFamiTF323368.

Miscellaneous databases

PROiQ5XIA4.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCNO10_RAT
AccessioniPrimary (citable) accession number: Q5XIA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.