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Protein

Lysosome-associated membrane glycoprotein 3

Gene

Lamp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity.By similarity

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
CD_antigen: CD208
Gene namesi
Name:Lamp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1307928. Lamp3.

Subcellular locationi

  • Lysosome membrane By similarity; Single-pass type I membrane protein Sequence analysis
  • Cytoplasmic vesicle membrane By similarity; Single-pass type I membrane protein Sequence analysis

  • Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 373LumenalSequence analysisAdd BLAST353
Transmembranei374 – 394HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini395 – 408CytoplasmicPROSITE-ProRule annotationAdd BLAST14

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000022369821 – 408Lysosome-associated membrane glycoprotein 3Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi230 ↔ 267PROSITE-ProRule annotation
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi331 ↔ 368PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5XI99.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022792.
GenevisibleiQ5XI99. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038456.

Structurei

3D structure databases

SMRiQ5XI99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 198Thr-richAdd BLAST161

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ5XI99.
KOiK06562.
OMAiCQSSGYQ.
OrthoDBiEOG091G09EV.
PhylomeDBiQ5XI99.
TreeFamiTF316339.

Family and domain databases

InterProiView protein in InterPro
IPR002000. Lysosome-assoc_membr_glycop.
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiView protein in Pfam
PF01299. Lamp. 1 hit.
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiView protein in PROSITE
PS51407. LAMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGQTSAVAV LLCLAVILHG YQIREKEFPE ARGYLQYTAT TTEQITAKPP
60 70 80 90 100
LPLTNQTSHA TLASRSKDDY IQTAAETSTF EDTAHITMKT AIPVTTKSLL
110 120 130 140 150
PISSTSYTFV RTNNSHMTAS STEDTIGSGS ITHLPFPTTR ASLAAVNHIT
160 170 180 190 200
GRSTQLGGQT TLPKALFTPS HESTTTQRPT LSTIVSELTP TGKDRSTTSS
210 220 230 240 250
VPLVPRPTFV TWSSPAKIGT YEVLNGSRLC IKAEMGIALI VQEKGLDSAT
260 270 280 290 300
QRHFNIDPSL THASGKCGSQ NSNLFLNFQG GSVNVTFTKE ENLYYVSEVG
310 320 330 340 350
AYLTISNTEK TYQGKSTMMM FETVVGHSFK CVSEQSIQLS AQLQMKTMNI
360 370 380 390 400
HLQAFDFEGD SFGIVDECLS DYTVVLPVVG IIVVVLCVVG LGIYKIRQRR

QSSAYQRI
Length:408
Mass (Da):44,388
Last modified:November 23, 2004 - v1
Checksum:i45FBA0878F0EABE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083787 mRNA. Translation: AAH83787.1.
RefSeqiNP_001012015.1. NM_001012015.1.
XP_017453457.1. XM_017597968.1.
UniGeneiRn.19784.

Genome annotation databases

EnsembliENSRNOT00000034498; ENSRNOP00000038456; ENSRNOG00000022792.
GeneIDi303801.
KEGGirno:303801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083787 mRNA. Translation: AAH83787.1.
RefSeqiNP_001012015.1. NM_001012015.1.
XP_017453457.1. XM_017597968.1.
UniGeneiRn.19784.

3D structure databases

SMRiQ5XI99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038456.

Proteomic databases

PaxDbiQ5XI99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034498; ENSRNOP00000038456; ENSRNOG00000022792.
GeneIDi303801.
KEGGirno:303801.

Organism-specific databases

CTDi27074.
RGDi1307928. Lamp3.

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ5XI99.
KOiK06562.
OMAiCQSSGYQ.
OrthoDBiEOG091G09EV.
PhylomeDBiQ5XI99.
TreeFamiTF316339.

Miscellaneous databases

PROiPR:Q5XI99.

Gene expression databases

BgeeiENSRNOG00000022792.
GenevisibleiQ5XI99. RN.

Family and domain databases

InterProiView protein in InterPro
IPR002000. Lysosome-assoc_membr_glycop.
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiView protein in Pfam
PF01299. Lamp. 1 hit.
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiView protein in PROSITE
PS51407. LAMP_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP3_RAT
AccessioniPrimary (citable) accession number: Q5XI99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 23, 2004
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.