Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysosome-associated membrane glycoprotein 3

Gene

Lamp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
CD_antigen: CD208
Gene namesi
Name:Lamp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1307928. Lamp3.

Subcellular locationi

  • Lysosome membrane By similarity; Single-pass type I membrane protein Sequence analysis
  • Cytoplasmic vesicle membrane By similarity; Single-pass type I membrane protein Sequence analysis

  • Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 373353LumenalSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini395 – 40814CytoplasmicPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • alveolar lamellar body membrane Source: ParkinsonsUK-UCL
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 408388Lysosome-associated membrane glycoprotein 3PRO_0000223698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi230 ↔ 267PROSITE-ProRule annotation
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence analysis
Disulfide bondi331 ↔ 368PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5XI99.
PRIDEiQ5XI99.

Expressioni

Gene expression databases

GenevisibleiQ5XI99. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038456.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 198161Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ5XI99.
KOiK06562.
OMAiYYISEVG.
OrthoDBiEOG7ZD1VH.
PhylomeDBiQ5XI99.
TreeFamiTF316339.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGQTSAVAV LLCLAVILHG YQIREKEFPE ARGYLQYTAT TTEQITAKPP
60 70 80 90 100
LPLTNQTSHA TLASRSKDDY IQTAAETSTF EDTAHITMKT AIPVTTKSLL
110 120 130 140 150
PISSTSYTFV RTNNSHMTAS STEDTIGSGS ITHLPFPTTR ASLAAVNHIT
160 170 180 190 200
GRSTQLGGQT TLPKALFTPS HESTTTQRPT LSTIVSELTP TGKDRSTTSS
210 220 230 240 250
VPLVPRPTFV TWSSPAKIGT YEVLNGSRLC IKAEMGIALI VQEKGLDSAT
260 270 280 290 300
QRHFNIDPSL THASGKCGSQ NSNLFLNFQG GSVNVTFTKE ENLYYVSEVG
310 320 330 340 350
AYLTISNTEK TYQGKSTMMM FETVVGHSFK CVSEQSIQLS AQLQMKTMNI
360 370 380 390 400
HLQAFDFEGD SFGIVDECLS DYTVVLPVVG IIVVVLCVVG LGIYKIRQRR

QSSAYQRI
Length:408
Mass (Da):44,388
Last modified:November 23, 2004 - v1
Checksum:i45FBA0878F0EABE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083787 mRNA. Translation: AAH83787.1.
RefSeqiNP_001012015.1. NM_001012015.1.
XP_006248657.1. XM_006248595.2.
XP_008767108.1. XM_008768886.1.
XP_008767109.1. XM_008768887.1.
UniGeneiRn.19784.

Genome annotation databases

EnsembliENSRNOT00000034498; ENSRNOP00000038456; ENSRNOG00000022792.
GeneIDi303801.
KEGGirno:303801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083787 mRNA. Translation: AAH83787.1.
RefSeqiNP_001012015.1. NM_001012015.1.
XP_006248657.1. XM_006248595.2.
XP_008767108.1. XM_008768886.1.
XP_008767109.1. XM_008768887.1.
UniGeneiRn.19784.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038456.

Proteomic databases

PaxDbiQ5XI99.
PRIDEiQ5XI99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034498; ENSRNOP00000038456; ENSRNOG00000022792.
GeneIDi303801.
KEGGirno:303801.

Organism-specific databases

CTDi27074.
RGDi1307928. Lamp3.

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ5XI99.
KOiK06562.
OMAiYYISEVG.
OrthoDBiEOG7ZD1VH.
PhylomeDBiQ5XI99.
TreeFamiTF316339.

Miscellaneous databases

NextBioi652111.
PROiQ5XI99.

Gene expression databases

GenevisibleiQ5XI99. RN.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiLAMP3_RAT
AccessioniPrimary (citable) accession number: Q5XI99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.