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Protein

Ribonuclease H2 subunit B

Gene

Rnaseh2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit B
Short name:
RNase H2 subunit B
Alternative name(s):
Ribonuclease HI subunit B
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1359710 Rnaseh2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002483802 – 307Ribonuclease H2 subunit BAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei291N6-acetyllysineBy similarity1
Modified residuei292PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XI96
PRIDEiQ5XI96

Expressioni

Gene expression databases

BgeeiENSRNOG00000009192
GenevisibleiQ5XI96 RN

Interactioni

Subunit structurei

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012231

Structurei

3D structure databases

SMRiQ5XI96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase H2 subunit B family.Curated

Phylogenomic databases

eggNOGiKOG4705 Eukaryota
ENOG410YS7I LUCA
GeneTreeiENSGT00390000011439
HOGENOMiHOG000006910
HOVERGENiHBG056010
InParanoidiQ5XI96
KOiK10744
OMAiNPEIDNK
OrthoDBiEOG091G0M4Q
PhylomeDBiQ5XI96
TreeFamiTF105250

Family and domain databases

CDDicd09270 RNase_H2-B, 1 hit
InterProiView protein in InterPro
IPR019024 RNase_H2_suB
PANTHERiPTHR13383 PTHR13383, 1 hit
PfamiView protein in Pfam
PF09468 RNase_H2-Ydr279, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGRDRGDL AARQLVFLLP EYLKDASRKS KSGLLFVKLV NPHSGEGATY
60 70 80 90 100
LIDACLQKLF EIKVFKEKHH SWFINQSVQS GGLLHFATPM DPLFLLLHYL
110 120 130 140 150
IKAGKEGKYQ PLDQVVVDDK FPDCTLLLRF PELEKSLRHV TEEKEVNSKK
160 170 180 190 200
YYKYSTEKTL KWLEKKVNQT VAALKANHVN VGARVQSSAY FSGVQVSRDK
210 220 230 240 250
EEDYVRYAHG LISDYIPKEL SDDLSKLLKL PEPPASLPNP PAKKLKLADE
260 270 280 290 300
PVEAKEDYTK FNTKDLKNGK KNSKMTAAQK ALAKVDKSGM KSIDAFFGAK

NKKTGKI
Length:307
Mass (Da):34,573
Last modified:November 23, 2004 - v1
Checksum:iB6FDD88D8939100B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083791 mRNA Translation: AAH83791.1
RefSeqiNP_001007008.1, NM_001007007.1
UniGeneiRn.16136

Genome annotation databases

EnsembliENSRNOT00000012231; ENSRNOP00000012231; ENSRNOG00000009192
GeneIDi361056
KEGGirno:361056
UCSCiRGD:1359710 rat

Similar proteinsi

Entry informationi

Entry nameiRNH2B_RAT
AccessioniPrimary (citable) accession number: Q5XI96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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