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Protein

Ribonuclease H2 subunit B

Gene

Rnaseh2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit B
Short name:
RNase H2 subunit B
Alternative name(s):
Ribonuclease HI subunit B
Gene namesi
Name:Rnaseh2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359710. Rnaseh2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 307306Ribonuclease H2 subunit BPRO_0000248380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei291 – 2911N6-acetyllysineBy similarity
Modified residuei292 – 2921PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XI96.
PRIDEiQ5XI96.

Expressioni

Gene expression databases

GenevisibleiQ5XI96. RN.

Interactioni

Subunit structurei

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012231.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase H2 subunit B family.Curated

Phylogenomic databases

eggNOGiKOG4705. Eukaryota.
ENOG410YS7I. LUCA.
GeneTreeiENSGT00390000011439.
HOGENOMiHOG000006910.
HOVERGENiHBG056010.
InParanoidiQ5XI96.
KOiK10744.
OMAiRMACDIV.
OrthoDBiEOG741Z2J.
PhylomeDBiQ5XI96.
TreeFamiTF105250.

Family and domain databases

InterProiIPR019024. RNase_H2_suB.
[Graphical view]
PfamiPF09468. RNase_H2-Ydr279. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGRDRGDL AARQLVFLLP EYLKDASRKS KSGLLFVKLV NPHSGEGATY
60 70 80 90 100
LIDACLQKLF EIKVFKEKHH SWFINQSVQS GGLLHFATPM DPLFLLLHYL
110 120 130 140 150
IKAGKEGKYQ PLDQVVVDDK FPDCTLLLRF PELEKSLRHV TEEKEVNSKK
160 170 180 190 200
YYKYSTEKTL KWLEKKVNQT VAALKANHVN VGARVQSSAY FSGVQVSRDK
210 220 230 240 250
EEDYVRYAHG LISDYIPKEL SDDLSKLLKL PEPPASLPNP PAKKLKLADE
260 270 280 290 300
PVEAKEDYTK FNTKDLKNGK KNSKMTAAQK ALAKVDKSGM KSIDAFFGAK

NKKTGKI
Length:307
Mass (Da):34,573
Last modified:November 23, 2004 - v1
Checksum:iB6FDD88D8939100B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083791 mRNA. Translation: AAH83791.1.
RefSeqiNP_001007008.1. NM_001007007.1.
UniGeneiRn.16136.

Genome annotation databases

EnsembliENSRNOT00000012231; ENSRNOP00000012231; ENSRNOG00000009192.
GeneIDi361056.
KEGGirno:361056.
UCSCiRGD:1359710. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083791 mRNA. Translation: AAH83791.1.
RefSeqiNP_001007008.1. NM_001007007.1.
UniGeneiRn.16136.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012231.

Proteomic databases

PaxDbiQ5XI96.
PRIDEiQ5XI96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012231; ENSRNOP00000012231; ENSRNOG00000009192.
GeneIDi361056.
KEGGirno:361056.
UCSCiRGD:1359710. rat.

Organism-specific databases

CTDi79621.
RGDi1359710. Rnaseh2b.

Phylogenomic databases

eggNOGiKOG4705. Eukaryota.
ENOG410YS7I. LUCA.
GeneTreeiENSGT00390000011439.
HOGENOMiHOG000006910.
HOVERGENiHBG056010.
InParanoidiQ5XI96.
KOiK10744.
OMAiRMACDIV.
OrthoDBiEOG741Z2J.
PhylomeDBiQ5XI96.
TreeFamiTF105250.

Miscellaneous databases

PROiQ5XI96.

Gene expression databases

GenevisibleiQ5XI96. RN.

Family and domain databases

InterProiIPR019024. RNase_H2_suB.
[Graphical view]
PfamiPF09468. RNase_H2-Ydr279. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiRNH2B_RAT
AccessioniPrimary (citable) accession number: Q5XI96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 23, 2004
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.