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Protein

Alcohol dehydrogenase 6

Gene

Adh6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei371NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-2161541 Abacavir metabolism
R-RNO-5365859 RA biosynthesis pathway
R-RNO-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 6 (EC:1.1.1.1)
Gene namesi
Name:Adh6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1306313 Adh6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606901 – 376Alcohol dehydrogenase 6Add BLAST376

Proteomic databases

PaxDbiQ5XI95
PRIDEiQ5XI95

PTM databases

PhosphoSitePlusiQ5XI95

Expressioni

Gene expression databases

BgeeiENSRNOG00000012436
ExpressionAtlasiQ5XI95 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030638

Structurei

3D structure databases

ProteinModelPortaliQ5XI95
SMRiQ5XI95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiQ5XI95
KOiK13952
PhylomeDBiQ5XI95
TreeFamiTF300429

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XI95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTQGKVIRC KATVLWKPGA PLAIEEIEVA PPKAKEVRIK MVATGVCGTD
60 70 80 90 100
IKHLDTQELS KFCPMIMGHE GVGIVESVGE GVSSVRTGDK VILLCIPQCG
110 120 130 140 150
ECKTCLNSKN NICTEIRLSK THLASEGTSR ITCKGKLVHQ YIALGSFSEY
160 170 180 190 200
TVLKEISVAK IDEGAPLEKV CIIGCGFATG YGAAINSAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVII GCKAAGAARI IAVDINKDRF AKAKTVGATD CVDPRDFEKP
260 270 280 290 300
IEEVLSDMID GGVDFCFEVT GNTEAVGAAL GSCHKDHGVC VTVGALASFT
310 320 330 340 350
STLSIRSHLF FSGRILKGSI LGGWKTKEEI PKLVSDYMAK KFNIDPLITH
360 370
TLTLSEANEA VQLMKSGQCI RCVLLL
Length:376
Mass (Da):39,726
Last modified:November 23, 2004 - v1
Checksum:i49C31B0A17684C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083792 mRNA Translation: AAH83792.1
RefSeqiNP_001012084.1, NM_001012084.1
UniGeneiRn.214994

Genome annotation databases

EnsembliENSRNOT00000036993; ENSRNOP00000030638; ENSRNOG00000012436
GeneIDi310903
KEGGirno:310903

Similar proteinsi

Entry informationi

Entry nameiADH6_RAT
AccessioniPrimary (citable) accession number: Q5XI95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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