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Protein

Alcohol dehydrogenase 6

Gene

Adh6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalyticBy similarity
Metal bindingi69 – 691Zinc 1; catalyticBy similarity
Metal bindingi99 – 991Zinc 2By similarity
Metal bindingi102 – 1021Zinc 2By similarity
Metal bindingi105 – 1051Zinc 2By similarity
Metal bindingi113 – 1131Zinc 2By similarity
Metal bindingi175 – 1751Zinc 1; catalyticBy similarity
Binding sitei224 – 2241NADBy similarity
Binding sitei229 – 2291NADBy similarity
Binding sitei371 – 3711NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2056NADBy similarity
Nucleotide bindingi293 – 2953NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-2161541. Abacavir metabolism.
R-RNO-5365859. RA biosynthesis pathway.
R-RNO-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 6 (EC:1.1.1.1)
Gene namesi
Name:Adh6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1306313. Adh6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Alcohol dehydrogenase 6PRO_0000160690Add
BLAST

Proteomic databases

PaxDbiQ5XI95.
PRIDEiQ5XI95.

PTM databases

PhosphoSiteiQ5XI95.

Expressioni

Gene expression databases

ExpressionAtlasiQ5XI95. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030638.

Structurei

3D structure databases

ProteinModelPortaliQ5XI95.
SMRiQ5XI95. Positions 5-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ5XI95.
KOiK13952.
OMAiVELMKTG.
OrthoDBiEOG72NRQ6.
PhylomeDBiQ5XI95.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTQGKVIRC KATVLWKPGA PLAIEEIEVA PPKAKEVRIK MVATGVCGTD
60 70 80 90 100
IKHLDTQELS KFCPMIMGHE GVGIVESVGE GVSSVRTGDK VILLCIPQCG
110 120 130 140 150
ECKTCLNSKN NICTEIRLSK THLASEGTSR ITCKGKLVHQ YIALGSFSEY
160 170 180 190 200
TVLKEISVAK IDEGAPLEKV CIIGCGFATG YGAAINSAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVII GCKAAGAARI IAVDINKDRF AKAKTVGATD CVDPRDFEKP
260 270 280 290 300
IEEVLSDMID GGVDFCFEVT GNTEAVGAAL GSCHKDHGVC VTVGALASFT
310 320 330 340 350
STLSIRSHLF FSGRILKGSI LGGWKTKEEI PKLVSDYMAK KFNIDPLITH
360 370
TLTLSEANEA VQLMKSGQCI RCVLLL
Length:376
Mass (Da):39,726
Last modified:November 23, 2004 - v1
Checksum:i49C31B0A17684C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083792 mRNA. Translation: AAH83792.1.
RefSeqiNP_001012084.1. NM_001012084.1.
UniGeneiRn.214994.

Genome annotation databases

EnsembliENSRNOT00000036993; ENSRNOP00000030638; ENSRNOG00000012436.
GeneIDi310903.
KEGGirno:310903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083792 mRNA. Translation: AAH83792.1.
RefSeqiNP_001012084.1. NM_001012084.1.
UniGeneiRn.214994.

3D structure databases

ProteinModelPortaliQ5XI95.
SMRiQ5XI95. Positions 5-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030638.

PTM databases

PhosphoSiteiQ5XI95.

Proteomic databases

PaxDbiQ5XI95.
PRIDEiQ5XI95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036993; ENSRNOP00000030638; ENSRNOG00000012436.
GeneIDi310903.
KEGGirno:310903.

Organism-specific databases

CTDi130.
RGDi1306313. Adh6.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ5XI95.
KOiK13952.
OMAiVELMKTG.
OrthoDBiEOG72NRQ6.
PhylomeDBiQ5XI95.
TreeFamiTF300429.

Enzyme and pathway databases

ReactomeiR-RNO-2161541. Abacavir metabolism.
R-RNO-5365859. RA biosynthesis pathway.
R-RNO-71384. Ethanol oxidation.

Miscellaneous databases

NextBioi662804.
PROiQ5XI95.

Gene expression databases

ExpressionAtlasiQ5XI95. baseline and differential.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiADH6_RAT
AccessioniPrimary (citable) accession number: Q5XI95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.