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Protein

Fragile X mental retardation syndrome-related protein 1

Gene

Fxr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 1
Gene namesi
Name:Fxr1By similarity
Synonyms:Fxr1hImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311733. Fxr1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 568567Fragile X mental retardation syndrome-related protein 1PRO_0000248488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei68 – 681PhosphotyrosineBy similarity
Modified residuei398 – 3981PhosphothreonineCombined sources
Modified residuei430 – 4301PhosphothreonineBy similarity
Modified residuei432 – 4321PhosphoserineCombined sources
Modified residuei435 – 4351PhosphoserineCombined sources
Modified residuei438 – 4381PhosphoserineCombined sources
Modified residuei449 – 4491PhosphoserineCombined sources
Modified residuei452 – 4521PhosphoserineCombined sources
Modified residuei474 – 4741Omega-N-methylated arginineBy similarity
Modified residuei512 – 5121PhosphothreonineCombined sources
Modified residuei514 – 5141PhosphoserineCombined sources
Modified residuei553 – 5531PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ5XI81.

PTM databases

iPTMnetiQ5XI81.
PhosphoSiteiQ5XI81.

Interactioni

Subunit structurei

Interacts with FMR1. Interacts with FRX2. Interacts with TDRD3. Interacts with CYFIP2 but not with CYFIP1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5XI81.
SMRiQ5XI81. Positions 1-134, 219-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 5047Agenet-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 11553Agenet-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini218 – 27962KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini281 – 35171KH 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 48616RNA-binding RGG-boxSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 534Poly-ProSequence analysis
Compositional biasi531 – 5399Poly-ArgSequence analysis

Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.By similarity

Sequence similaritiesi

Belongs to the FMR1 family.Sequence analysis
Contains 2 Agenet-like domains.PROSITE-ProRule annotation
Contains 2 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000293377.
HOVERGENiHBG005739.
InParanoidiQ5XI81.
KOiK15516.
PhylomeDBiQ5XI81.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 1 hit.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELTVEVRG SNGAFYKVFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP
60 70 80 90 100
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD
110 120 130 140 150
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF
160 170 180 190 200
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS
210 220 230 240 250
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV
260 270 280 290 300
TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
310 320 330 340 350
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL
360 370 380 390 400
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EKEKGYATDE
410 420 430 440 450
STVSSVQGSR SYSGRGRGRR GPNYTSGYGT NSELSNPSET ESERKDELSD
460 470 480 490 500
WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG GRGRGGPRGG KSSISSVLKD
510 520 530 540 550
PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT DEDAVLMDGM
560
TESDTASVNE NGLGKRCD
Length:568
Mass (Da):63,947
Last modified:November 23, 2004 - v1
Checksum:iC6FBCD4F23B248AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083807 mRNA. Translation: AAH83807.1.
RefSeqiNP_001012179.1. NM_001012179.2.
UniGeneiRn.40468.

Genome annotation databases

GeneIDi361927.
KEGGirno:361927.
UCSCiRGD:1311733. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083807 mRNA. Translation: AAH83807.1.
RefSeqiNP_001012179.1. NM_001012179.2.
UniGeneiRn.40468.

3D structure databases

ProteinModelPortaliQ5XI81.
SMRiQ5XI81. Positions 1-134, 219-359.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5XI81.
PhosphoSiteiQ5XI81.

Proteomic databases

PRIDEiQ5XI81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361927.
KEGGirno:361927.
UCSCiRGD:1311733. rat.

Organism-specific databases

CTDi8087.
RGDi1311733. Fxr1.

Phylogenomic databases

HOGENOMiHOG000293377.
HOVERGENiHBG005739.
InParanoidiQ5XI81.
KOiK15516.
PhylomeDBiQ5XI81.

Miscellaneous databases

PROiQ5XI81.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 1 hit.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-398; SER-432; SER-435; SER-438; SER-449; SER-452; THR-512 AND SER-514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFXR1_RAT
AccessioniPrimary (citable) accession number: Q5XI81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 23, 2004
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein corresponds to isoform B in mouse and isoform 2 in human.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.