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Protein

Fragile X mental retardation syndrome-related protein 1

Gene

Fxr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).By similarity

Miscellaneous

This protein corresponds to isoform B in mouse and isoform 2 in human.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 1
Gene namesi
Name:Fxr1By similarity
Synonyms:Fxr1hImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311733. Fxr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002484882 – 568Fragile X mental retardation syndrome-related protein 1Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei68PhosphotyrosineBy similarity1
Modified residuei398PhosphothreonineCombined sources1
Modified residuei430PhosphothreonineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei449PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei474Omega-N-methylated arginineBy similarity1
Modified residuei512PhosphothreonineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei553PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ5XI81.

PTM databases

iPTMnetiQ5XI81.
PhosphoSitePlusiQ5XI81.

Interactioni

Subunit structurei

Interacts with FMR1. Interacts with FRX2. Interacts with TDRD3. Interacts with HABP4. Interacts with CYFIP2 but not with CYFIP1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5XI81.
SMRiQ5XI81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 50Agenet-like 1PROSITE-ProRule annotationAdd BLAST47
Domaini63 – 115Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini218 – 279KH 1PROSITE-ProRule annotationAdd BLAST62
Domaini281 – 351KH 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni471 – 486RNA-binding RGG-boxSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 53Poly-ProSequence analysis4
Compositional biasi531 – 539Poly-ArgSequence analysis9

Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.By similarity

Sequence similaritiesi

Belongs to the FMR1 family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000293377.
HOVERGENiHBG005739.
InParanoidiQ5XI81.
KOiK15516.
PhylomeDBiQ5XI81.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiView protein in InterPro
IPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR036612. KH_dom_type_1_sf.
PfamiView protein in Pfam
PF05641. Agenet. 1 hit.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF00013. KH_1. 2 hits.
SMARTiView protein in SMART
SM00322. KH. 2 hits.
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiView protein in PROSITE
PS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELTVEVRG SNGAFYKVFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP
60 70 80 90 100
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD
110 120 130 140 150
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF
160 170 180 190 200
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS
210 220 230 240 250
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV
260 270 280 290 300
TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
310 320 330 340 350
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL
360 370 380 390 400
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EKEKGYATDE
410 420 430 440 450
STVSSVQGSR SYSGRGRGRR GPNYTSGYGT NSELSNPSET ESERKDELSD
460 470 480 490 500
WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG GRGRGGPRGG KSSISSVLKD
510 520 530 540 550
PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT DEDAVLMDGM
560
TESDTASVNE NGLGKRCD
Length:568
Mass (Da):63,947
Last modified:November 23, 2004 - v1
Checksum:iC6FBCD4F23B248AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083807 mRNA. Translation: AAH83807.1.
RefSeqiNP_001012179.1. NM_001012179.2.
UniGeneiRn.40468.

Genome annotation databases

GeneIDi361927.
KEGGirno:361927.
UCSCiRGD:1311733. rat.

Similar proteinsi

Entry informationi

Entry nameiFXR1_RAT
AccessioniPrimary (citable) accession number: Q5XI81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families