Q5XI73 (GDIR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GDP-dissociation inhibitor 1
Short name=Rho GDI 1

Alternative name(s):
Rho-GDI alpha

Gene names

Name:

Arhgdia

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them By similarity. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. Ref.3 UniProtKB P19803
Subunit structure	Monomer. Interacts with FER By similarity. Forms a heterodimer with RAC1. Interacts with PLXNB3. Interacts with PLXNB3. Interacts with PSMD10 and RHOA; the interaction with PSMD10 increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation By similarity. Ref.3
Subcellular location	Cytoplasm Ref.2.
Sequence similarities	Belongs to the Rho GDI family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	GTPase activation
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Rho protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of protein localization Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell immunological synapse Inferred from electronic annotation. Source: Compara
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW Rho GDP-dissociation inhibitor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P52565
	Chain	2 – 204	203	Rho GDP-dissociation inhibitor 1 UniProtKB P52565		PRO_0000349124
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity UniProtKB P52565
	Modified residue	105	1	N6-acetyllysine By similarity
	Modified residue	127	1	N6-acetyllysine By similarity
	Modified residue	141	1	N6-acetyllysine By similarity UniProtKB P52565
	Modified residue	178	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5XI73 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 8ACE6F4456D842D8	FASTA	204	23,407
	10 20 30 40 50 60 MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA 70 80 90 100 110 120 VSADPNVPNV IVTRLTLVCS TAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR 130 140 150 160 170 180 EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PMEEAPKGML ARGSYNIKSR 190 200 FTDDDKTDHL SWEWNLTIKK EWKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Brown Norway. Tissue: Kidney.
[2]	"Proteome profile of the mature rat olfactory bulb." Maurya D.K., Sundaram C.S., Bhargava P. Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[3]	"Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase." Li X., Lee A.Y. J. Biol. Chem. 285:32436-32445(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PLXNB3 AND RAC1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC083817 mRNA. Translation: AAH83817.1.
IPI	IPI00196994.
RefSeq	NP_001007006.1. NM_001007005.1.
UniGene	Rn.1801.
3D structure databases
HSSP	HSSP built from PDB template 1HH4 based on UniProtKB P52565.
ProteinModelPortal	Q5XI73.
SMR	Q5XI73. Positions 5-204.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5XI73. 1 interaction.
STRING	10116.ENSRNOP00000051840.
PTM databases
PhosphoSite	Q5XI73.
2D gel databases
World-2DPAGE	0004:Q5XI73.
Proteomic databases
PaxDb	Q5XI73.
PRIDE	Q5XI73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000054957; ENSRNOP00000051840; ENSRNOG00000036688.
GeneID	360678.
KEGG	rno:360678.
Organism-specific databases
CTD	396.
RGD	1359547. Arhgdia.
Phylogenomic databases
eggNOG	NOG289931.
GeneTree	ENSGT00390000006233.
HOGENOM	HOG000175765.
HOVERGEN	HBG000206.
InParanoid	Q5XI73.
KO	K12462.
OMA	HLSWEWS.
OrthoDB	EOG4Q58QJ.
Gene expression databases
Genevestigator	Q5XI73.
Family and domain databases
Gene3D	2.70.50.30. 1 hit.
InterPro	IPR014756. Ig_E-set. IPR000406. Rho_GDI. IPR024792. RhoGDI_domain. [Graphical view]
PANTHER	PTHR10980. PTHR10980. 1 hit.
Pfam	PF02115. Rho_GDI. 1 hit. [Graphical view]
PRINTS	PR00492. RHOGDI.
SUPFAM	SSF81296. Ig_E-set. 1 hit.
ProtoNet	Search...
Other
NextBio	673734.

Entry information

Entry name

GDIR1_RAT

Accession

Primary (citable) accession number: Q5XI73

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program