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Q5XI73

- GDIR1_RAT

UniProt

Q5XI73 - GDIR1_RAT

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Protein
Rho GDP-dissociation inhibitor 1
Gene
Arhgdia
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. Rho GDP-dissociation inhibitor activity Source: Ensembl
  3. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. Rho protein signal transduction Source: Ensembl
  2. negative regulation of cell migration Source: UniProtKB
  3. regulation of protein localization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_197601. Axonal growth stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 1
Short name:
Rho GDI 1
Alternative name(s):
Rho-GDI alpha
Gene namesi
Name:Arhgdia
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1359547. Arhgdia.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. immunological synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarityBy similarity
Chaini2 – 204203Rho GDP-dissociation inhibitor 1By similarity
PRO_0000349124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarityBy similarity
Modified residuei34 – 341Phosphoserine By similarity
Modified residuei43 – 431N6-acetyllysine By similarity
Modified residuei105 – 1051N6-acetyllysine By similarity
Modified residuei127 – 1271N6-acetyllysine By similarity
Modified residuei141 – 1411N6-acetyllysine; alternate By similarityBy similarity
Modified residuei141 – 1411N6-succinyllysine; alternate By similarity
Modified residuei178 – 1781N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XI73.
PRIDEiQ5XI73.

2D gel databases

World-2DPAGEi0004:Q5XI73.

PTM databases

PhosphoSiteiQ5XI73.

Expressioni

Gene expression databases

GenevestigatoriQ5XI73.

Interactioni

Subunit structurei

Monomer. Interacts with FER. Interacts with PLXNB3. Forms a heterodimer with RAC1. Interacts with RHOA, the affinity is increased by three orders of magnitude when RHOA is prenylated. Interacts with PSMD10; the interaction increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation. Interacts with RHOC and CDC42.1 Publication

Protein-protein interaction databases

BioGridi262122. 3 interactions.
IntActiQ5XI73. 2 interactions.
STRINGi10116.ENSRNOP00000051840.

Structurei

3D structure databases

ProteinModelPortaliQ5XI73.
SMRiQ5XI73. Positions 5-204.

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.

Phylogenomic databases

eggNOGiNOG289931.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ5XI73.
KOiK12462.
OMAiEGVEYQI.
OrthoDBiEOG72JWH9.
PhylomeDBiQ5XI73.
TreeFamiTF105387.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI73-1 [UniParc]FASTAAdd to Basket

« Hide

MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK    50
YKEALLGRVA VSADPNVPNV IVTRLTLVCS TAPGPLELDL TGDLESFKKQ 100
SFVLKEGVEY RIKISFRVNR EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG 150
PRAEEYEFLT PMEEAPKGML ARGSYNIKSR FTDDDKTDHL SWEWNLTIKK 200
EWKD 204
Length:204
Mass (Da):23,407
Last modified:November 23, 2004 - v1
Checksum:i8ACE6F4456D842D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC083817 mRNA. Translation: AAH83817.1.
RefSeqiNP_001007006.1. NM_001007005.1.
XP_006247959.1. XM_006247897.1.
XP_006247960.1. XM_006247898.1.
UniGeneiRn.1801.

Genome annotation databases

EnsembliENSRNOT00000054957; ENSRNOP00000051840; ENSRNOG00000036688.
GeneIDi360678.
KEGGirno:360678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC083817 mRNA. Translation: AAH83817.1 .
RefSeqi NP_001007006.1. NM_001007005.1.
XP_006247959.1. XM_006247897.1.
XP_006247960.1. XM_006247898.1.
UniGenei Rn.1801.

3D structure databases

ProteinModelPortali Q5XI73.
SMRi Q5XI73. Positions 5-204.
ModBasei Search...

Protein-protein interaction databases

BioGridi 262122. 3 interactions.
IntActi Q5XI73. 2 interactions.
STRINGi 10116.ENSRNOP00000051840.

PTM databases

PhosphoSitei Q5XI73.

2D gel databases

World-2DPAGEi 0004:Q5XI73.

Proteomic databases

PaxDbi Q5XI73.
PRIDEi Q5XI73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000054957 ; ENSRNOP00000051840 ; ENSRNOG00000036688 .
GeneIDi 360678.
KEGGi rno:360678.

Organism-specific databases

CTDi 396.
RGDi 1359547. Arhgdia.

Phylogenomic databases

eggNOGi NOG289931.
GeneTreei ENSGT00390000006233.
HOGENOMi HOG000175765.
HOVERGENi HBG000206.
InParanoidi Q5XI73.
KOi K12462.
OMAi EGVEYQI.
OrthoDBi EOG72JWH9.
PhylomeDBi Q5XI73.
TreeFami TF105387.

Enzyme and pathway databases

Reactomei REACT_197601. Axonal growth stimulation.

Miscellaneous databases

NextBioi 673734.
PROi Q5XI73.

Gene expression databases

Genevestigatori Q5XI73.

Family and domain databases

Gene3Di 2.70.50.30. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view ]
PANTHERi PTHR10980. PTHR10980. 1 hit.
Pfami PF02115. Rho_GDI. 1 hit.
[Graphical view ]
PRINTSi PR00492. RHOGDI.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Kidney.
  2. "Proteome profile of the mature rat olfactory bulb."
    Maurya D.K., Sundaram C.S., Bhargava P.
    Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  3. "Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase."
    Li X., Lee A.Y.
    J. Biol. Chem. 285:32436-32445(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PLXNB3 AND RAC1.

Entry informationi

Entry nameiGDIR1_RAT
AccessioniPrimary (citable) accession number: Q5XI73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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