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Q5XI73

- GDIR1_RAT

UniProt

Q5XI73 - GDIR1_RAT

Protein

Rho GDP-dissociation inhibitor 1

Gene

Arhgdia

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.1 Publication

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. Rho GDP-dissociation inhibitor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of cell migration Source: UniProtKB
    2. regulation of protein localization Source: Ensembl
    3. Rho protein signal transduction Source: Ensembl
    4. semaphorin-plexin signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_197601. Axonal growth stimulation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GDP-dissociation inhibitor 1By similarity
    Short name:
    Rho GDI 1By similarity
    Alternative name(s):
    Rho-GDI alphaBy similarity
    Gene namesi
    Name:ArhgdiaImported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1359547. Arhgdia.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. immunological synapse Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 204203Rho GDP-dissociation inhibitor 1By similarityPRO_0000349124Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei34 – 341PhosphoserineBy similarity
    Modified residuei43 – 431N6-acetyllysineBy similarity
    Modified residuei105 – 1051N6-acetyllysineBy similarity
    Modified residuei127 – 1271N6-acetyllysineBy similarity
    Modified residuei141 – 1411N6-acetyllysine; alternateBy similarity
    Modified residuei141 – 1411N6-succinyllysine; alternateBy similarity
    Modified residuei178 – 1781N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ5XI73.
    PRIDEiQ5XI73.

    2D gel databases

    World-2DPAGE0004:Q5XI73.

    PTM databases

    PhosphoSiteiQ5XI73.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XI73.

    Interactioni

    Subunit structurei

    Monomer. Interacts with FER. Interacts with PLXNB3. Forms a heterodimer with RAC1. Interacts with RHOA, the affinity is increased by three orders of magnitude when RHOA is prenylated. Interacts with PSMD10; the interaction increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation. Interacts with RHOC and CDC42.1 Publication

    Protein-protein interaction databases

    BioGridi262122. 3 interactions.
    IntActiQ5XI73. 2 interactions.
    STRINGi10116.ENSRNOP00000051840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XI73.
    SMRiQ5XI73. Positions 5-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Rho GDI family.Sequence Analysis

    Phylogenomic databases

    eggNOGiNOG289931.
    GeneTreeiENSGT00390000006233.
    HOGENOMiHOG000175765.
    HOVERGENiHBG000206.
    InParanoidiQ5XI73.
    KOiK12462.
    OMAiEGVEYQI.
    OrthoDBiEOG72JWH9.
    PhylomeDBiQ5XI73.
    TreeFamiTF105387.

    Family and domain databases

    Gene3Di2.70.50.30. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR000406. Rho_GDI.
    IPR024792. RhoGDI_domain.
    [Graphical view]
    PANTHERiPTHR10980. PTHR10980. 1 hit.
    PfamiPF02115. Rho_GDI. 1 hit.
    [Graphical view]
    PRINTSiPR00492. RHOGDI.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5XI73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK    50
    YKEALLGRVA VSADPNVPNV IVTRLTLVCS TAPGPLELDL TGDLESFKKQ 100
    SFVLKEGVEY RIKISFRVNR EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG 150
    PRAEEYEFLT PMEEAPKGML ARGSYNIKSR FTDDDKTDHL SWEWNLTIKK 200
    EWKD 204
    Length:204
    Mass (Da):23,407
    Last modified:November 23, 2004 - v1
    Checksum:i8ACE6F4456D842D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083817 mRNA. Translation: AAH83817.1.
    RefSeqiNP_001007006.1. NM_001007005.1.
    XP_006247959.1. XM_006247897.1.
    XP_006247960.1. XM_006247898.1.
    UniGeneiRn.1801.

    Genome annotation databases

    EnsembliENSRNOT00000054957; ENSRNOP00000051840; ENSRNOG00000036688.
    GeneIDi360678.
    KEGGirno:360678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083817 mRNA. Translation: AAH83817.1 .
    RefSeqi NP_001007006.1. NM_001007005.1.
    XP_006247959.1. XM_006247897.1.
    XP_006247960.1. XM_006247898.1.
    UniGenei Rn.1801.

    3D structure databases

    ProteinModelPortali Q5XI73.
    SMRi Q5XI73. Positions 5-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 262122. 3 interactions.
    IntActi Q5XI73. 2 interactions.
    STRINGi 10116.ENSRNOP00000051840.

    PTM databases

    PhosphoSitei Q5XI73.

    2D gel databases

    World-2DPAGE 0004:Q5XI73.

    Proteomic databases

    PaxDbi Q5XI73.
    PRIDEi Q5XI73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000054957 ; ENSRNOP00000051840 ; ENSRNOG00000036688 .
    GeneIDi 360678.
    KEGGi rno:360678.

    Organism-specific databases

    CTDi 396.
    RGDi 1359547. Arhgdia.

    Phylogenomic databases

    eggNOGi NOG289931.
    GeneTreei ENSGT00390000006233.
    HOGENOMi HOG000175765.
    HOVERGENi HBG000206.
    InParanoidi Q5XI73.
    KOi K12462.
    OMAi EGVEYQI.
    OrthoDBi EOG72JWH9.
    PhylomeDBi Q5XI73.
    TreeFami TF105387.

    Enzyme and pathway databases

    Reactomei REACT_197601. Axonal growth stimulation.

    Miscellaneous databases

    NextBioi 673734.
    PROi Q5XI73.

    Gene expression databases

    Genevestigatori Q5XI73.

    Family and domain databases

    Gene3Di 2.70.50.30. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR000406. Rho_GDI.
    IPR024792. RhoGDI_domain.
    [Graphical view ]
    PANTHERi PTHR10980. PTHR10980. 1 hit.
    Pfami PF02115. Rho_GDI. 1 hit.
    [Graphical view ]
    PRINTSi PR00492. RHOGDI.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Brown Norway1 Publication.
      Tissue: KidneyImported.
    2. "Proteome profile of the mature rat olfactory bulb."
      Maurya D.K., Sundaram C.S., Bhargava P.
      Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    3. "Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase."
      Li X., Lee A.Y.
      J. Biol. Chem. 285:32436-32445(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PLXNB3 AND RAC1.

    Entry informationi

    Entry nameiGDIR1_RAT
    AccessioniPrimary (citable) accession number: Q5XI73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3