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Protein

Eukaryotic translation initiation factor 4H

Gene

Eif4h

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72662. Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4H
Short name:
eIF-4H
Alternative name(s):
Williams-Beuren syndrome chromosomal region 1 protein homolog
Gene namesi
Name:Eif4h
Synonyms:Wbscr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1359222. Eif4h.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002837022 – 248Eukaryotic translation initiation factor 4HAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei19Omega-N-methylarginineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei22Omega-N-methylarginineBy similarity1
Modified residuei24PhosphoserineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei136Omega-N-methylarginineBy similarity1
Modified residuei166Omega-N-methylarginineBy similarity1
Modified residuei175Omega-N-methylarginineBy similarity1
Modified residuei230PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XI72.
PRIDEiQ5XI72.

PTM databases

iPTMnetiQ5XI72.
PhosphoSitePlusiQ5XI72.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001454.
ExpressionAtlasiQ5XI72. baseline and differential.
GenevisibleiQ5XI72. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043254.

Structurei

3D structure databases

ProteinModelPortaliQ5XI72.
SMRiQ5XI72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 118RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00530000063406.
HOGENOMiHOG000013063.
HOVERGENiHBG018193.
InParanoidiQ5XI72.
OMAiKVNRAQQ.
OrthoDBiEOG091G0PIF.
PhylomeDBiQ5XI72.
TreeFamiTF313897.

Family and domain databases

CDDicd12401. RRM_eIF4H. 1 hit.
InterProiView protein in InterPro
IPR034229. eIF4H_RRM.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP
60 70 80 90 100
FNTVQGDIDA IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT
110 120 130 140 150
YDGALLGDRS LRVDIAEGRK QDKGGFGFRK GGPDDRGMGG SREPRGGWDS
160 170 180 190 200
RDDFSSGYRD DFLGGRGGSR PGDRRAGPPM GSRFRDGPPL RGSNMDFREP
210 220 230 240
TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE EVVQKEQE
Length:248
Mass (Da):27,324
Last modified:November 23, 2004 - v1
Checksum:i8E1BE53690380954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083818 mRNA. Translation: AAH83818.1.
RefSeqiNP_001006958.1. NM_001006957.2.
UniGeneiRn.79423.

Genome annotation databases

EnsembliENSRNOT00000050059; ENSRNOP00000043254; ENSRNOG00000001454.
GeneIDi288599.
KEGGirno:288599.
UCSCiRGD:1359222. rat.

Similar proteinsi

Entry informationi

Entry nameiIF4H_RAT
AccessioniPrimary (citable) accession number: Q5XI72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 23, 2004
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries