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Protein

Polycomb group RING finger protein 6

Gene

Pcgf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 174RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 6
Alternative name(s):
RING finger protein 134
Gene namesi
Name:Pcgf6
Synonyms:Rnf134
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306904 Pcgf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559911 – 351Polycomb group RING finger protein 6Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki235Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated during mitosis.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5XI70
PRIDEiQ5XI70

Expressioni

Gene expression databases

BgeeiENSRNOG00000020250
GenevisibleiQ5XI70 RN

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027450

Structurei

3D structure databases

ProteinModelPortaliQ5XI70
SMRiQ5XI70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 110Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 68Pro-richAdd BLAST44
Compositional biasi65 – 121Glu-richAdd BLAST57

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 174RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231946
HOVERGENiHBG052826
InParanoidiQ5XI70
KOiK11470
OMAiCIVKHFF
OrthoDBiEOG091G0EC9
PhylomeDBiQ5XI70
TreeFamiTF324206

Family and domain databases

Gene3Di3.30.40.101 hit
InterProiView protein in InterPro
IPR038037 PCGF6
IPR029071 Ubiquitin-like_domsf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825:SF15 PTHR10825:SF15, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XI70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAETDATE NKRASEAKRA SAMLPPPPPP ISPPALIPAP AAGEEGPASL
60 70 80 90 100
AQAGAPGCSR SRPPELEPER SLGRLRGRFE DYDEELEEDE EMEEEEEEEE
110 120 130 140 150
EMSHFSLRLE SGRADSEDEE ERLINLVELT PYILCSICKG YLIDATTITE
160 170 180 190 200
CLHTFCKSCI VRHFYYSNRC PKCNIVVHQT QPLYNIRLDR QLQDIVYKLV
210 220 230 240 250
VNLEEREKKQ MHDFYKERGL EVPKPAVPQP VPASKGRTKK ALESVFRIPP
260 270 280 290 300
ELDVSLLLEF IGANEDTGHF KPLEKKFVRV SGEATIGHVE KFLRRKMGLD
310 320 330 340 350
PACQVDIICG DHLLERYQTL REIRRAIGDT AMQDGLLVLH YGLVVSPLKI

T
Length:351
Mass (Da):39,706
Last modified:November 23, 2004 - v1
Checksum:iABD5B92FFAED7462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083820 mRNA Translation: AAH83820.1
RefSeqiNP_001013172.1, NM_001013154.1
UniGeneiRn.16897

Genome annotation databases

EnsembliENSRNOT00000027450; ENSRNOP00000027450; ENSRNOG00000020250
GeneIDi309457
KEGGirno:309457
UCSCiRGD:1306904 rat

Similar proteinsi

Entry informationi

Entry nameiPCGF6_RAT
AccessioniPrimary (citable) accession number: Q5XI70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome