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Protein

Polycomb group RING finger protein 6

Gene

Pcgf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri135 – 17440RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 6
Alternative name(s):
RING finger protein 134
Gene namesi
Name:Pcgf6
Synonyms:Rnf134
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306904. Pcgf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Polycomb group RING finger protein 6PRO_0000055991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei116 – 1161PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated during mitosis.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XI70.
PRIDEiQ5XI70.

Expressioni

Gene expression databases

GenevisibleiQ5XI70. RN.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027450.

Structurei

3D structure databases

ProteinModelPortaliQ5XI70.
SMRiQ5XI70. Positions 124-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili69 – 11042Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 6844Pro-richAdd
BLAST
Compositional biasi65 – 12157Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri135 – 17440RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ5XI70.
KOiK11470.
OMAiIGANEDT.
OrthoDBiEOG754HQ5.
PhylomeDBiQ5XI70.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR029071. Ubiquitin-rel_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAETDATE NKRASEAKRA SAMLPPPPPP ISPPALIPAP AAGEEGPASL
60 70 80 90 100
AQAGAPGCSR SRPPELEPER SLGRLRGRFE DYDEELEEDE EMEEEEEEEE
110 120 130 140 150
EMSHFSLRLE SGRADSEDEE ERLINLVELT PYILCSICKG YLIDATTITE
160 170 180 190 200
CLHTFCKSCI VRHFYYSNRC PKCNIVVHQT QPLYNIRLDR QLQDIVYKLV
210 220 230 240 250
VNLEEREKKQ MHDFYKERGL EVPKPAVPQP VPASKGRTKK ALESVFRIPP
260 270 280 290 300
ELDVSLLLEF IGANEDTGHF KPLEKKFVRV SGEATIGHVE KFLRRKMGLD
310 320 330 340 350
PACQVDIICG DHLLERYQTL REIRRAIGDT AMQDGLLVLH YGLVVSPLKI

T
Length:351
Mass (Da):39,706
Last modified:November 23, 2004 - v1
Checksum:iABD5B92FFAED7462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083820 mRNA. Translation: AAH83820.1.
RefSeqiNP_001013172.1. NM_001013154.1.
UniGeneiRn.16897.

Genome annotation databases

EnsembliENSRNOT00000027450; ENSRNOP00000027450; ENSRNOG00000020250.
GeneIDi309457.
KEGGirno:309457.
UCSCiRGD:1306904. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083820 mRNA. Translation: AAH83820.1.
RefSeqiNP_001013172.1. NM_001013154.1.
UniGeneiRn.16897.

3D structure databases

ProteinModelPortaliQ5XI70.
SMRiQ5XI70. Positions 124-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027450.

Proteomic databases

PaxDbiQ5XI70.
PRIDEiQ5XI70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027450; ENSRNOP00000027450; ENSRNOG00000020250.
GeneIDi309457.
KEGGirno:309457.
UCSCiRGD:1306904. rat.

Organism-specific databases

CTDi84108.
RGDi1306904. Pcgf6.

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ5XI70.
KOiK11470.
OMAiIGANEDT.
OrthoDBiEOG754HQ5.
PhylomeDBiQ5XI70.
TreeFamiTF324206.

Miscellaneous databases

NextBioi660834.
PROiQ5XI70.

Gene expression databases

GenevisibleiQ5XI70. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR029071. Ubiquitin-rel_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPCGF6_RAT
AccessioniPrimary (citable) accession number: Q5XI70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.