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Protein

F-box only protein 30

Gene

Fbxo30

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri49 – 10860TRAF-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 30
Gene namesi
Name:Fbxo30
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359367. Fbxo30.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 742742F-box only protein 30PRO_0000119920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei379 – 3791PhosphoserineCombined sources

Post-translational modificationi

Auto-ubiquitinated.By similarity
May be neddylated. Neddylation may be required for E3 ligase activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5XI67.
PRIDEiQ5XI67.

PTM databases

iPTMnetiQ5XI67.
PhosphoSiteiQ5XI67.

Expressioni

Gene expression databases

GenevisibleiQ5XI67. RN.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019918.

Structurei

3D structure databases

ProteinModelPortaliQ5XI67.
SMRiQ5XI67. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini607 – 65347F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri49 – 10860TRAF-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH36. Eukaryota.
ENOG410XQPH. LUCA.
GeneTreeiENSGT00410000025582.
HOGENOMiHOG000059618.
HOVERGENiHBG051574.
InParanoidiQ5XI67.
KOiK10307.
OMAiDPMGLQG.
OrthoDBiEOG71VSS1.
PhylomeDBiQ5XI67.
TreeFamiTF343227.

Family and domain databases

Gene3Di3.90.890.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR031890. Fbxo30/Fbxo40.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR15933. PTHR15933. 3 hits.
PfamiPF15966. F-box_4. 1 hit.
PF15965. zf-TRAF_2. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEVQQHSH CVNCVSRRCM TRPEPGVSCD LIGCPLVCGA VFHSCKADEH
60 70 80 90 100
RLLCPFERVP CLNSNFGCPF TLARNKVAEH LEMCPASVVC CTMEWNRWPV
110 120 130 140 150
SYSDRKSYES LSRDADEVSQ LDMALALQDQ RMLLESLKVA TMMSKATGKI
160 170 180 190 200
SKPREQISVN SSVQEVPRAN GLVSADEESY GALYEATVET TRSLAAALDI
210 220 230 240 250
LNSATRDIGM LNTSLQGTTN EMDEESNRES SQDRNAKDQD HLDEGEIGAV
260 270 280 290 300
GGIDYTGTSQ NAQAEQNGSS DLLCNLNTSS YDTSALCNGF PLEKMCTQVK
310 320 330 340 350
DQDQNFHGDS TESNITNGDC VEADGTSEPP SSLLVAEQLK EGSALPDSTY
360 370 380 390 400
QHILMPDEDD DEDLCWKKDL GDSKDVNGSP LSHATSFKFL SNSWYIPKED
410 420 430 440 450
KAVDTSDLEV AEDPMGLQGI DLITAALLFC LGDSPGGRGI SDSRMVDVYH
460 470 480 490 500
VDFGTQTFSL PSAILATNTM VGEIASASAC DHANPQLSNP SPFQTLGLDL
510 520 530 540 550
VLECVARYQP KQRSMFTFVC GQLFRRKEFS SHFKNVHGDI HAGLNGWMEQ
560 570 580 590 600
RCPLAYYGCT YSQRRFCPST QGAKIIHDRH LRSFGVQPCV STALEEPSRN
610 620 630 640 650
CVLGLRSDHL SSLPFEVLQH IAGFLDGFSL CQLACVSRLM RDICGSLLQS
660 670 680 690 700
RGMVILQWGK KKYPEGNSSW QIKEKVWRFS TAFCSVNDWK FADILSMADH
710 720 730 740
LKKCSYNVIE KREEAIPLPC MCVTRELTKE GRSLRSVLKP VL
Length:742
Mass (Da):82,011
Last modified:November 23, 2004 - v1
Checksum:i93BBE53E36E621C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083823 mRNA. Translation: AAH83823.1.
RefSeqiNP_001007691.1. NM_001007690.1.
XP_006227702.1. XM_006227640.2.
UniGeneiRn.204927.

Genome annotation databases

EnsembliENSRNOT00000019918; ENSRNOP00000019918; ENSRNOG00000014852.
GeneIDi308283.
KEGGirno:308283.
UCSCiRGD:1359367. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083823 mRNA. Translation: AAH83823.1.
RefSeqiNP_001007691.1. NM_001007690.1.
XP_006227702.1. XM_006227640.2.
UniGeneiRn.204927.

3D structure databases

ProteinModelPortaliQ5XI67.
SMRiQ5XI67. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019918.

PTM databases

iPTMnetiQ5XI67.
PhosphoSiteiQ5XI67.

Proteomic databases

PaxDbiQ5XI67.
PRIDEiQ5XI67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019918; ENSRNOP00000019918; ENSRNOG00000014852.
GeneIDi308283.
KEGGirno:308283.
UCSCiRGD:1359367. rat.

Organism-specific databases

CTDi84085.
RGDi1359367. Fbxo30.

Phylogenomic databases

eggNOGiENOG410IH36. Eukaryota.
ENOG410XQPH. LUCA.
GeneTreeiENSGT00410000025582.
HOGENOMiHOG000059618.
HOVERGENiHBG051574.
InParanoidiQ5XI67.
KOiK10307.
OMAiDPMGLQG.
OrthoDBiEOG71VSS1.
PhylomeDBiQ5XI67.
TreeFamiTF343227.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ5XI67.

Gene expression databases

GenevisibleiQ5XI67. RN.

Family and domain databases

Gene3Di3.90.890.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR031890. Fbxo30/Fbxo40.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR15933. PTHR15933. 3 hits.
PfamiPF15966. F-box_4. 1 hit.
PF15965. zf-TRAF_2. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-379, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFBX30_RAT
AccessioniPrimary (citable) accession number: Q5XI67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.