Q5XI65 (CC164_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 164

Gene names

Name:

Ccdc164

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	754 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending By similarity.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme By similarity.
Sequence similarities	Belongs to the CCDC164 family.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonemal dynein complex assembly Inferred from sequence or structural similarity. Source: UniProtKB ciliary cell motility Inferred from sequence or structural similarity. Source: UniProtKB flagellar cell motility Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cilium axoneme Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 754	754	Coiled-coil domain-containing protein 164		PRO_0000277884
Regions
	Coiled coil	98 – 388	291	Potential
	Coiled coil	704 – 743	40	Potential
	Compositional bias	449 – 452	4	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q5XI65 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 085DF289B3268FB6	FASTA	754	88,310
	10 20 30 40 50 60 MNPSGSIGVL EQNGEEHLAA PILGPSVNSD NPQERIQARR LRIAARQEAR RREALGEYLD 70 80 90 100 110 120 GKKESEEEQS KSYKQKEESR LKLTKLLLCG TELVTNIQVA ADIREIHRRV EEEETKRQRL 130 140 150 160 170 180 EKLENEVKTS QDKFDEITSK WEEGRQKRIP QELWEMLNNQ QVHCAGLVED KNKLISELQQ 190 200 210 220 230 240 ELKIKDDQYV KDLKKQSEDI TVLLERMEEQ VKSVMKNFRQ ELNYIEKAFE SERQELLTTN 250 260 270 280 290 300 KKKWERALQA HNAKELEYLI NRMKRVEDYE KQLNRQRVWD CEEYNSIKIK LEQDVQILEQ 310 320 330 340 350 360 QLQQMKATYQ LNQEKLEYNF QVLKKRDEES TVIKSQQKRK LNRLHDILNN LRTKYSKQIK 370 380 390 400 410 420 QFQEDNQSLT SDYKRLVTQF KDLQKAIRHF IIIDQDKFRE IWLMNEAEAK ELAQRAFDVD 430 440 450 460 470 480 KIIHSQHLGL PWKIPNFWFL NNVGPISLQQ QQKSVTQILE ELLLQSEDEG TETAMSEDES 490 500 510 520 530 540 YMDLPNQVSA KTTKKILVLL CDESGFLIES KLLSLLLPLE KSECYLLRLD AIFSALGIES 550 560 570 580 590 600 EDDLYKMVNF FLRFKAHHLS SAQVSISTHS NAERTSLVSA LQHMSLMSQT DRRSSASKSD 610 620 630 640 650 660 GDPTELEDQQ GSDNGSLMGR ELVEQEDLSS PMFIHPNDVL KILDAFVTGL KKPKDARPVQ 670 680 690 700 710 720 RLKKDTRNNL KDTEYWESLA MVIPFSKQNL WDALFKALEK YYLVLTQRAK LLMENDSLEQ 730 740 750 QNAEMQSLLQ QYLQAKVNLE LQVPPTQGFR MPSK

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC083825 mRNA. Translation: AAH83825.1.
IPI	IPI00365585.
RefSeq	NP_001007010.1. NM_001007009.1.
UniGene	Rn.51279.
3D structure databases
ProteinModelPortal	Q5XI65.
ModBase	Search...
PTM databases
PhosphoSite	Q5XI65.
Proteomic databases
PaxDb	Q5XI65.
PRIDE	Q5XI65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000036815; ENSRNOP00000031362; ENSRNOG00000024905.
GeneID	362712.
KEGG	rno:362712.
Organism-specific databases
CTD	92749.
RGD	1359318. Ccdc164.
Phylogenomic databases
eggNOG	NOG80321.
GeneTree	ENSGT00530000063699.
HOVERGEN	HBG080997.
InParanoid	Q5XI65.
OrthoDB	EOG457566.
Gene expression databases
Genevestigator	Q5XI65.
Family and domain databases
ProtoNet	Search...
Other
NextBio	680972.

Entry information

Entry name

CC164_RAT

Accession

Primary (citable) accession number: Q5XI65

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program