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Protein

Monoacylglycerol lipase ABHD6

Gene

Abhd6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481NucleophileBy similarity
Active sitei278 – 2781Charge relay systemBy similarity
Active sitei306 – 3061Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-426048. Arachidonate production from DAG.

Protein family/group databases

ESTHERirat-abhd6. ABHD6-Lip.

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD6Curated (EC:3.1.1.23By similarity)
Alternative name(s):
2-arachidonoylglycerol hydrolaseBy similarity
Abhydrolase domain-containing protein 6Imported
Gene namesi
Name:Abhd6Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359323. Abhd6.

Subcellular locationi

  • Membrane By similarity; Single-pass type II membrane protein Sequence analysis
  • Mitochondrion By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88ExtracellularSequence analysis
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini30 – 337308CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Monoacylglycerol lipase ABHD6PRO_0000281577Add
BLAST

Proteomic databases

PaxDbiQ5XI64.
PRIDEiQ5XI64.

Expressioni

Gene expression databases

GenevisibleiQ5XI64. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4577465.
STRINGi10116.ENSRNOP00000012271.

Structurei

3D structure databases

ProteinModelPortaliQ5XI64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPFK. Eukaryota.
ENOG410XZ30. LUCA.
GeneTreeiENSGT00510000047225.
HOGENOMiHOG000008016.
HOVERGENiHBG059524.
InParanoidiQ5XI64.
KOiK13700.
OMAiKTANLIL.
OrthoDBiEOG786H3D.
PhylomeDBiQ5XI64.
TreeFamiTF331946.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XI64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV
60 70 80 90 100
RYVHHEDYQF CYSFRGRPGH KPSVLMLHGF SAHKDMWLSV VKFLPKNLHL
110 120 130 140 150
VCVDMPGHEG TTRSSLDDLS IVGQVKRIHQ FVECLKLNKK PFHLIGTSMG
160 170 180 190 200
GNVAGVYAAY YPSDVCSLSL VCPAGLQYST DNRFVQRLKE LEDSAATQKI
210 220 230 240 250
PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN SFYRKLFLEI
260 270 280 290 300
VSEKSRYSLH ENMDKIKVPT QIIWGKQDQV LDVSGADILA KSITNSQVEV
310 320 330
LENCGHSVVM ERPRKTAKLV VDFLASVHNP DNNKKLN
Length:337
Mass (Da):38,312
Last modified:November 23, 2004 - v1
Checksum:iBDE7B746E276023E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083826 mRNA. Translation: AAH83826.1.
RefSeqiNP_001007681.1. NM_001007680.1.
XP_006251828.1. XM_006251766.2.
XP_006251829.1. XM_006251767.2.
XP_006251830.1. XM_006251768.2.
UniGeneiRn.15395.

Genome annotation databases

EnsembliENSRNOT00000012271; ENSRNOP00000012271; ENSRNOG00000008167.
ENSRNOT00000080794; ENSRNOP00000074573; ENSRNOG00000008167.
GeneIDi305795.
KEGGirno:305795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083826 mRNA. Translation: AAH83826.1.
RefSeqiNP_001007681.1. NM_001007680.1.
XP_006251828.1. XM_006251766.2.
XP_006251829.1. XM_006251767.2.
XP_006251830.1. XM_006251768.2.
UniGeneiRn.15395.

3D structure databases

ProteinModelPortaliQ5XI64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4577465.
STRINGi10116.ENSRNOP00000012271.

Protein family/group databases

ESTHERirat-abhd6. ABHD6-Lip.

Proteomic databases

PaxDbiQ5XI64.
PRIDEiQ5XI64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012271; ENSRNOP00000012271; ENSRNOG00000008167.
ENSRNOT00000080794; ENSRNOP00000074573; ENSRNOG00000008167.
GeneIDi305795.
KEGGirno:305795.

Organism-specific databases

CTDi57406.
RGDi1359323. Abhd6.

Phylogenomic databases

eggNOGiENOG410IPFK. Eukaryota.
ENOG410XZ30. LUCA.
GeneTreeiENSGT00510000047225.
HOGENOMiHOG000008016.
HOVERGENiHBG059524.
InParanoidiQ5XI64.
KOiK13700.
OMAiKTANLIL.
OrthoDBiEOG786H3D.
PhylomeDBiQ5XI64.
TreeFamiTF331946.

Enzyme and pathway databases

ReactomeiR-RNO-426048. Arachidonate production from DAG.

Miscellaneous databases

NextBioi655021.
PROiQ5XI64.

Gene expression databases

GenevisibleiQ5XI64. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 245-254, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiABHD6_RAT
AccessioniPrimary (citable) accession number: Q5XI64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.