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Protein

Kinesin-like protein KIFC1

Gene

Kifc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi430 – 4378ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC1
Alternative name(s):
Kinesin-related protein 1
Gene namesi
Name:Kifc1Imported
Synonyms:Krp1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1359118. Kifc1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
  • Cytoplasmcytoskeletonspindle By similarity
  • Early endosome By similarity

  • Note: Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Kinesin-like protein KIFC1PRO_0000302090Add
BLAST

Proteomic databases

PaxDbiQ5XI63.
PRIDEiQ5XI63.

Expressioni

Gene expression databases

GenevisibleiQ5XI63. RN.

Interactioni

Subunit structurei

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061875.

Structurei

3D structure databases

ProteinModelPortaliQ5XI63.
SMRiQ5XI63. Positions 330-681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini330 – 683354Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili165 – 334170Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000116164.
HOVERGENiHBG001080.
InParanoidiQ5XI63.
KOiK10405.
OMAiWQETAAQ.
OrthoDBiEOG72G16X.
PhylomeDBiQ5XI63.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGRGSRDTG TQSAAFASRP VRTTVDMQAQ RAPLMEVKRN LELSTTLVKS
60 70 80 90 100
SSRLPLPGSR LKRGPDQMED GLEPAKKRTR GMGTVTKVDT SRPRGPPLSA
110 120 130 140 150
VSTAAQKGPR KTGPRGCSAV GPVLRNQKPA PAAPAQKPGT STAPAVAGKK
160 170 180 190 200
PGKRPAWDLK GQLCDLHEEL KQYREKTQTL DRENQGLREQ LREVQEQATT
210 220 230 240 250
LGTERNTLEE ELASVRRRAE QSQQKLETLG ARVLELEECL GTKERLVQEL
260 270 280 290 300
QTERLQLQEE RSTLSTQLEE REREFQASEA ALSSSRAEVL CLRQKTAAQV
310 320 330 340 350
TLLAEQGDRL YGLEMERRRL HNQLQELKGN IRVFCRVRPV LEGESTPSPG
360 370 380 390 400
FLVFPPGPAG PSDPPTRLCL SRSDDRRSTL TRAPAAATRH DFSFDRVFPP
410 420 430 440 450
GSKQEEVFEE ISMLVQSALD GYPVCIFAYG QTGSGKTFTM EGGPRGDPQL
460 470 480 490 500
EGLIPRAMRH LFSVAQEMSG QGWTYSFVAS YVEIYNETVR DLLATGTRKG
510 520 530 540 550
QGGDCEIRRA GPGSEELTVT NARYVPVSCE KEVEALLHLA QQNRAVARTA
560 570 580 590 600
QNERSSRSHS VFQLQISGEH AARGLQCGAP LNLVDLAGSE RLDPGLTLGP
610 620 630 640 650
GERDRLRETQ AINSSLSTLG LVIMALSNKE SHVPYRNSKL TYLLQNSLGG
660 670 680 690
SAKMLMFVNI SPLEENVSES LNSLRFASKV NQCVIGTAQA NKK
Length:693
Mass (Da):76,141
Last modified:November 23, 2004 - v1
Checksum:i739A2EC8DD1845FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083827 mRNA. Translation: AAH83827.1.
AF035951 mRNA. Translation: AAB88699.1.
RefSeqiNP_001005878.1. NM_001005878.1.
UniGeneiRn.38181.

Genome annotation databases

EnsembliENSRNOT00000065349; ENSRNOP00000061875; ENSRNOG00000000479.
GeneIDi294286.
KEGGirno:294286.
UCSCiRGD:1359118. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083827 mRNA. Translation: AAH83827.1.
AF035951 mRNA. Translation: AAB88699.1.
RefSeqiNP_001005878.1. NM_001005878.1.
UniGeneiRn.38181.

3D structure databases

ProteinModelPortaliQ5XI63.
SMRiQ5XI63. Positions 330-681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061875.

Proteomic databases

PaxDbiQ5XI63.
PRIDEiQ5XI63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065349; ENSRNOP00000061875; ENSRNOG00000000479.
GeneIDi294286.
KEGGirno:294286.
UCSCiRGD:1359118. rat.

Organism-specific databases

CTDi3833.
RGDi1359118. Kifc1.

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000116164.
HOVERGENiHBG001080.
InParanoidiQ5XI63.
KOiK10405.
OMAiWQETAAQ.
OrthoDBiEOG72G16X.
PhylomeDBiQ5XI63.

Miscellaneous databases

PROiQ5XI63.

Gene expression databases

GenevisibleiQ5XI63. RN.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.
  2. "Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis."
    Sperry A.O., Zhao L.-P.
    Mol. Biol. Cell 7:289-305(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 426-588.
    Strain: Sprague-DawleyImported.
    Tissue: TestisImported.

Entry informationi

Entry nameiKIFC1_RAT
AccessioniPrimary (citable) accession number: Q5XI63
Secondary accession number(s): O54719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.