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Protein

RING finger protein 10

Gene

Rnf10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26743RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • transcription regulatory region DNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • negative regulation of Schwann cell proliferation Source: UniProtKB
  • positive regulation of myelination Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 10
Gene namesi
Name:Rnf10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309282. Rnf10.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802RING finger protein 10PRO_0000259587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphoserineBy similarity
Modified residuei110 – 1101PhosphoserineBy similarity
Modified residuei128 – 1281PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XI59.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001172.
GenevisibleiQ5XI59. RN.

Interactioni

Subunit structurei

Interacts with MEOX2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063855.

Structurei

3D structure databases

ProteinModelPortaliQ5XI59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 111108Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the RNF10 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26743RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2164. Eukaryota.
ENOG410XTFS. LUCA.
HOGENOMiHOG000006763.
HOVERGENiHBG059523.
InParanoidiQ5XI59.
OrthoDBiEOG091G05CI.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQSSPSTAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSNGS KRYNRKREPS YPKNENFSNQ SRRSNSQKSK TFNKTPPQRG
110 120 130 140 150
GGSSKPFSSS SNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQAGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTANF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSERTW SKCPICYSSV HKKDLKSVVA TESRQYVVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWMNVDHPIS LGDEQHSQYS KLLLASKEQV LHRVVLEEKV
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA ALQEVKIREE ALSGVAGGRA EVTGVVTALE
410 420 430 440 450
QLVLMAPLAK ESAFQPRKGV LEYLSAFDEE AAQVCSLDPP GPLALPLVEE
460 470 480 490 500
EEAVSEPEAC EDLIADDSLG EGTVCAELSQ EEPIAKPGFT QLSSSPCYYF
510 520 530 540 550
YQAEDGQHMF LHPVNVRCLV REYGSLEQSP EKISATVVEI AGYSMSEDVR
560 570 580 590 600
QRHRYLSHLP LTCEFSICEL ALQPPVVSKE TLEMFSDDIE KRKRQRQKKA
610 620 630 640 650
REERRRERRI ELEENKRQGR YPEVHIPLEN LQQFPAFNSY TCSSDSALGP
660 670 680 690 700
TSTEGHGALS LSPLSRSPGS HADFLLTPLS PTASQGSPSF CVGSLEEDSP
710 720 730 740 750
FLSFAQMLRV GKAKADGWPK AAPKKDDNSL APPAPVDSDG ESDNSDRVPV
760 770 780 790 800
PSFQNSFSQA IEAAFMKLDT PATSDPLSDR GGRKRKRQKQ KLLFSTSVVH

TK
Length:802
Mass (Da):88,410
Last modified:November 23, 2004 - v1
Checksum:iB71581B1A18A759C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083831 mRNA. Translation: AAH83831.1.
RefSeqiNP_001011904.1. NM_001011904.1.
UniGeneiRn.11656.

Genome annotation databases

GeneIDi288710.
KEGGirno:288710.
UCSCiRGD:1309282. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083831 mRNA. Translation: AAH83831.1.
RefSeqiNP_001011904.1. NM_001011904.1.
UniGeneiRn.11656.

3D structure databases

ProteinModelPortaliQ5XI59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063855.

Proteomic databases

PaxDbiQ5XI59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi288710.
KEGGirno:288710.
UCSCiRGD:1309282. rat.

Organism-specific databases

CTDi9921.
RGDi1309282. Rnf10.

Phylogenomic databases

eggNOGiKOG2164. Eukaryota.
ENOG410XTFS. LUCA.
HOGENOMiHOG000006763.
HOVERGENiHBG059523.
InParanoidiQ5XI59.
OrthoDBiEOG091G05CI.

Miscellaneous databases

PROiQ5XI59.

Gene expression databases

BgeeiENSRNOG00000001172.
GenevisibleiQ5XI59. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNF10_RAT
AccessioniPrimary (citable) accession number: Q5XI59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.