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Protein

Kinesin-like protein KIF2B

Gene

Kif2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi303 – 310ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-141444. Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.
R-RNO-5663220. RHO GTPases Activate Formins.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-RNO-68877. Mitotic Prometaphase.
R-RNO-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2B
Gene namesi
Name:Kif2bImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359248. Kif2b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003062761 – 664Kinesin-like protein KIF2BAdd BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125Phosphothreonine; by PLK1By similarity1
Modified residuei204Phosphoserine; by PLK1By similarity1

Post-translational modificationi

Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XI51.
PRIDEiQ5XI51.

PTM databases

PhosphoSitePlusiQ5XI51.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002535.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003421.

Structurei

3D structure databases

ProteinModelPortaliQ5XI51.
SMRiQ5XI51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 543Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 177Sequence analysisAdd BLAST29
Coiled coili642 – 663Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0246. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00870000136434.
HOGENOMiHOG000231329.
HOVERGENiHBG003875.
InParanoidiQ5XI51.
KOiK10393.
OMAiDGNQQIQ.
OrthoDBiEOG091G06V3.
PhylomeDBiQ5XI51.
TreeFamiTF105222.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR036961. Kinesin_motor_dom_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XI51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQFCLPLA PRLSPLKPLK SHFTDFQVGI CVAIQRSDKR IHLAVVTEIN
60 70 80 90 100
RENSWVTVEW VEKGVKKGKK IELETVLLLN PALASTEHQR SRRPLRPVSV
110 120 130 140 150
IPATAIGDQR TATKWIAMIP HRNETPSGDS QTLVIPSNPC LMKRKKSPCL
160 170 180 190 200
REIEKLQKQR EKRRRLQLEI RARRALDINT GNPNFETMRM IEEYRRHLDS
210 220 230 240 250
SKMSRLEPPE DHRICVCVRK RPLNERETTM KDLDIITIPS HNVVMVHESK
260 270 280 290 300
QKVDLTRYLE NQTFCFDHAF DDTASNELVY QFTARPLVES IFRKGMATCF
310 320 330 340 350
AYGQTGSGKT HTMGGAFSGK AQECSKGIYA LVAQDVFLLL RTPAYEKLEL
360 370 380 390 400
KVYGTFFEIY GGKVYDLLNW KKKLQVLEDG NQQIQVVGLQ EQEVGCVEEV
410 420 430 440 450
LNLVELGNSC RTSGQTSVNA HSSRSHAVFQ LILKCGGKLH GKFSLVDLAG
460 470 480 490 500
NERGADTAKA TRKRQLEGAE INKSLLALKE CIRALGKNKS HTPFRASKLT
510 520 530 540 550
QVLRDSFIGQ NSYTCMIATI SPGMTSCENT LNTLRYANRV KELALEARPY
560 570 580 590 600
PPTDHEMPLT LENGNTNSEK SLQKDDIIQI PTVQKEEEKE SDELTSTKEP
610 620 630 640 650
AASWSRSGPW WEAIQETAEG VNCDVDFCIA QSLSILEQKI GVLTEIQKKL
660
QLLRDDLQKK SQAE
Length:664
Mass (Da):75,004
Last modified:October 2, 2007 - v2
Checksum:i109BB199948EC7FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074230 Genomic DNA. No translation available.
BC083841 mRNA. Translation: AAH83841.1.
RefSeqiNP_001005874.2. NM_001005874.2.
UniGeneiRn.113616.

Genome annotation databases

EnsembliENSRNOT00000003421; ENSRNOP00000003421; ENSRNOG00000002535.
GeneIDi287624.
KEGGirno:287624.

Similar proteinsi

Entry informationi

Entry nameiKIF2B_RAT
AccessioniPrimary (citable) accession number: Q5XI51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 25, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families