Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Matrix-remodeling-associated protein 8

Gene

Mxra8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the maturation and maintenance of blood-brain barrier.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix-remodeling-associated protein 8
Alternative name(s):
Limitrin
Gene namesi
Name:Mxra8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1359356. Mxra8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 340321ExtracellularSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Topological domaini362 – 38221CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 382363Matrix-remodeling-associated protein 8PRO_0000298667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 136PROSITE-ProRule annotation
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi185 ↔ 271PROSITE-ProRule annotation
Modified residuei227 – 2271PhosphoserineBy similarity
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence analysis

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei324 – 3252Cleavage1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5XI43.
PRIDEiQ5XI43.

Expressioni

Gene expression databases

ExpressionAtlasiQ5XI43. baseline and differential.
GenevisibleiQ5XI43. RN.

Interactioni

Protein-protein interaction databases

IntActiQ5XI43. 1 interaction.
STRINGi10116.ENSRNOP00000058800.

Structurei

3D structure databases

ProteinModelPortaliQ5XI43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 156131Ig-like V-type 1Add
BLAST
Domaini159 – 291133Ig-like V-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVY. Eukaryota.
ENOG41113W9. LUCA.
GeneTreeiENSGT00390000001509.
HOGENOMiHOG000065729.
HOVERGENiHBG058527.
InParanoidiQ5XI43.
OMAiLLTCVNR.
OrthoDBiEOG71RXJW.
PhylomeDBiQ5XI43.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLSRVLLW KLVLLQSSAV LSSGSPGTAA ASSSVVSESA VSWAAGTQAV
60 70 80 90 100
LRCQSPRMVW TQDRLHDRQR VVHWDLSGGP GSQGRRLVDM YSAGEQRVYQ
110 120 130 140 150
PRDRDRLLLS PSAFHDGNFS LLIRAVERGD EGVYTCNLHH HYCHLYESLA
160 170 180 190 200
VRLEVTDDPL LSRAYWDGEK EVLVVALGAP ALMTCVNREH LWTDRHLEEA
210 220 230 240 250
QQVVHWDRQL PGVPHDRADR LLDLYASGER RAYGPPFLRD RVSVNTNAFA
260 270 280 290 300
RGDFSLRIDD LEPADEGIYS CHLHHHYCGL HERRVFHLRV TEPVFEPPAR
310 320 330 340 350
ASPGNGSGHN SVPSPDPTMA RGHSIINVIV PEDHTHFFQQ LGYVLATLLL
360 370 380
FILLLITVVL ATRHRHSGGC KTSDRKAGKS KG
Length:382
Mass (Da):42,735
Last modified:November 23, 2004 - v1
Checksum:iCC4192489450F0D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083849 mRNA. Translation: AAH83849.1.
RefSeqiNP_001007003.1. NM_001007002.1.
UniGeneiRn.2457.

Genome annotation databases

EnsembliENSRNOT00000067252; ENSRNOP00000058800; ENSRNOG00000019244.
GeneIDi313770.
KEGGirno:313770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083849 mRNA. Translation: AAH83849.1.
RefSeqiNP_001007003.1. NM_001007002.1.
UniGeneiRn.2457.

3D structure databases

ProteinModelPortaliQ5XI43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5XI43. 1 interaction.
STRINGi10116.ENSRNOP00000058800.

Proteomic databases

PaxDbiQ5XI43.
PRIDEiQ5XI43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067252; ENSRNOP00000058800; ENSRNOG00000019244.
GeneIDi313770.
KEGGirno:313770.

Organism-specific databases

CTDi54587.
RGDi1359356. Mxra8.

Phylogenomic databases

eggNOGiENOG410IJVY. Eukaryota.
ENOG41113W9. LUCA.
GeneTreeiENSGT00390000001509.
HOGENOMiHOG000065729.
HOVERGENiHBG058527.
InParanoidiQ5XI43.
OMAiLLTCVNR.
OrthoDBiEOG71RXJW.
PhylomeDBiQ5XI43.

Miscellaneous databases

PROiQ5XI43.

Gene expression databases

ExpressionAtlasiQ5XI43. baseline and differential.
GenevisibleiQ5XI43. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. Cited for: CLEAVAGE AFTER SER-324, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiMXRA8_RAT
AccessioniPrimary (citable) accession number: Q5XI43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.