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Protein

Aldehyde dehydrogenase family 3 member B1

Gene

Aldh3b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.By similarity

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210By similarity1
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-RNO-1660661 Sphingolipid de novo biosynthesis
R-RNO-6798695 Neutrophil degranulation
UniPathwayiUPA00780; UER00768

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B1 (EC:1.2.1.5)
Gene namesi
Name:Aldh3b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359546 Aldh3b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564831 – 465Aldehyde dehydrogenase family 3 member B1Add BLAST465
PropeptideiPRO_0000424195466 – 468Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Lipidationi462S-palmitoyl cysteineBy similarity1
Lipidationi463S-palmitoyl cysteineBy similarity1
Modified residuei465Cysteine methyl esterCurated1
Lipidationi465S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ5XI42
PRIDEiQ5XI42

PTM databases

PhosphoSitePlusiQ5XI42

Expressioni

Gene expression databases

BgeeiENSRNOG00000017512
ExpressionAtlasiQ5XI42 baseline and differential
GenevisibleiQ5XI42 RN

Interactioni

Protein-protein interaction databases

BioGridi259282, 1 interactor
STRINGi10116.ENSRNOP00000023789

Structurei

3D structure databases

ProteinModelPortaliQ5XI42
SMRiQ5XI42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00390000002825
HOGENOMiHOG000271515
HOVERGENiHBG050483
InParanoidiQ5XI42
KOiK00129
PhylomeDBiQ5XI42
TreeFamiTF314264

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSFEDKLQQ LREAFNAGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ
60 70 80 90 100
DLHKSAFESE VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI IVPWNYPLNL TLVPLVGAIA AGNCVVLKPS EISKATEKIL
160 170 180 190 200
AEVLPRYLDQ SCFAVVLGGP QETGQLLEHR FDYIFFTGNT YVGKIVMAAA
210 220 230 240 250
AKHLTPITLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA GQTCVAPDYV
260 270 280 290 300
LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FERLQGLLGC
310 320 330 340 350
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVTNLDE
360 370 380 390 400
AIEFINRREK PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL
410 420 430 440 450
PFGGVGTSGM GRYHGKFSFD TFSNQRACLL RSPGMEKIND LRYPPYTSRN
460
LRVLLVAMEK RCCSCTLL
Length:468
Mass (Da):52,147
Last modified:November 23, 2004 - v1
Checksum:i47AA217F9DC48935
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083850 mRNA Translation: AAH83850.1
RefSeqiNP_001006999.1, NM_001006998.1
XP_006230849.1, XM_006230787.3
XP_008758356.1, XM_008760134.1
UniGeneiRn.162510

Genome annotation databases

EnsembliENSRNOT00000023789; ENSRNOP00000023789; ENSRNOG00000017512
GeneIDi309147
KEGGirno:309147
UCSCiRGD:1359546 rat

Similar proteinsi

Entry informationi

Entry nameiAL3B1_RAT
AccessioniPrimary (citable) accession number: Q5XI42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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