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Protein

Aldehyde dehydrogenase family 3 member B1

Gene

Aldh3b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.By similarity

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei210 – 2101By similarity
Active sitei244 – 2441By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi188 – 1936NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B1 (EC:1.2.1.5)
Gene namesi
Name:Aldh3b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359546. Aldh3b1.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity

  • Note: Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Aldehyde dehydrogenase family 3 member B1PRO_0000056483Add
BLAST
Propeptidei466 – 4683Removed in mature formCuratedPRO_0000424195

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Lipidationi462 – 4621S-palmitoyl cysteineBy similarity
Lipidationi463 – 4631S-palmitoyl cysteineBy similarity
Modified residuei465 – 4651Cysteine methyl esterCurated
Lipidationi465 – 4651S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ5XI42.
PRIDEiQ5XI42.

PTM databases

PhosphoSiteiQ5XI42.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017512.
ExpressionAtlasiQ5XI42. baseline and differential.
GenevisibleiQ5XI42. RN.

Interactioni

Protein-protein interaction databases

BioGridi259282. 1 interaction.
STRINGi10116.ENSRNOP00000023789.

Structurei

3D structure databases

ProteinModelPortaliQ5XI42.
SMRiQ5XI42. Positions 4-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiQ5XI42.
KOiK00129.
PhylomeDBiQ5XI42.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSFEDKLQQ LREAFNAGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ
60 70 80 90 100
DLHKSAFESE VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI IVPWNYPLNL TLVPLVGAIA AGNCVVLKPS EISKATEKIL
160 170 180 190 200
AEVLPRYLDQ SCFAVVLGGP QETGQLLEHR FDYIFFTGNT YVGKIVMAAA
210 220 230 240 250
AKHLTPITLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA GQTCVAPDYV
260 270 280 290 300
LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FERLQGLLGC
310 320 330 340 350
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVTNLDE
360 370 380 390 400
AIEFINRREK PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL
410 420 430 440 450
PFGGVGTSGM GRYHGKFSFD TFSNQRACLL RSPGMEKIND LRYPPYTSRN
460
LRVLLVAMEK RCCSCTLL
Length:468
Mass (Da):52,147
Last modified:November 23, 2004 - v1
Checksum:i47AA217F9DC48935
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083850 mRNA. Translation: AAH83850.1.
RefSeqiNP_001006999.1. NM_001006998.1.
XP_006230849.1. XM_006230787.2.
XP_008758356.1. XM_008760134.1.
UniGeneiRn.162510.

Genome annotation databases

EnsembliENSRNOT00000023789; ENSRNOP00000023789; ENSRNOG00000017512.
GeneIDi309147.
KEGGirno:309147.
UCSCiRGD:1359546. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083850 mRNA. Translation: AAH83850.1.
RefSeqiNP_001006999.1. NM_001006998.1.
XP_006230849.1. XM_006230787.2.
XP_008758356.1. XM_008760134.1.
UniGeneiRn.162510.

3D structure databases

ProteinModelPortaliQ5XI42.
SMRiQ5XI42. Positions 4-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259282. 1 interaction.
STRINGi10116.ENSRNOP00000023789.

PTM databases

PhosphoSiteiQ5XI42.

Proteomic databases

PaxDbiQ5XI42.
PRIDEiQ5XI42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023789; ENSRNOP00000023789; ENSRNOG00000017512.
GeneIDi309147.
KEGGirno:309147.
UCSCiRGD:1359546. rat.

Organism-specific databases

CTDi221.
RGDi1359546. Aldh3b1.

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiQ5XI42.
KOiK00129.
PhylomeDBiQ5XI42.
TreeFamiTF314264.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

PROiQ5XI42.

Gene expression databases

BgeeiENSRNOG00000017512.
ExpressionAtlasiQ5XI42. baseline and differential.
GenevisibleiQ5XI42. RN.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL3B1_RAT
AccessioniPrimary (citable) accession number: Q5XI42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.