Reviewed, UniProtKB/Swiss-Prot Q5XI42 (AL3B1_RAT)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase family 3 member B1
    EC=1.2.1.5

Gene names

Name:

Aldh3b1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Aldehyde dehydrogenase family 3 member B1		PRO_0000056483
Regions
	Nucleotide binding	188 – 193	6	NAD By similarity
Sites
	Active site	210	1	By similarity
	Active site	244	1	By similarity
Amino acid modifications
	Modified residue	368	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5XI42-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 47AA217F9DC48935	FASTA	468	52,147
	10 20 30 40 50 60 MDSFEDKLQQ LREAFNAGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ DLHKSAFESE 70 80 90 100 110 120 VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI RKEPFGLVLI IVPWNYPLNL 130 140 150 160 170 180 TLVPLVGAIA AGNCVVLKPS EISKATEKIL AEVLPRYLDQ SCFAVVLGGP QETGQLLEHR 190 200 210 220 230 240 FDYIFFTGNT YVGKIVMAAA AKHLTPITLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA 250 260 270 280 290 300 GQTCVAPDYV LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FERLQGLLGC 310 320 330 340 350 360 GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVTNLDE AIEFINRREK 370 380 390 400 410 420 PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL PFGGVGTSGM GRYHGKFSFD 430 440 450 460 TFSNQRACLL RSPGMEKIND LRYPPYTSRN LRVLLVAMEK RCCSCTLL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Brown Norway. Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC083850 mRNA. Translation: AAH83850.1.
RefSeq	NP_001006999.1.
UniGene	Rn.162510
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5XI42.
Genome annotation databases
Ensembl	ENSRNOG00000017512. Rattus norvegicus. [Contig view]
GeneID	309147.
KEGG	rno:309147.
NMPDR	fig|10116.3.peg.3411.
Organism-specific databases
RGD	1359546. Aldh3b1.
Phylogenomic databases
HOVERGEN	Q5XI42.
Gene expression databases
ArrayExpress	Q5XI42.
GermOnline	ENSRNOG00000017512. Rattus norvegicus.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR012394. Ald_DHase_NAD(P). IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	660254.

Entry information

Entry name

AL3B1_RAT

Accession

Primary (citable) accession number: Q5XI42

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	November 23, 2004
Last modified:	November 25, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)