Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translocating chain-associated membrane protein 1

Gene

Tram1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulatory or required for the translocation of secretory proteins across the ER membrane.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane protein 1
Gene namesi
Name:Tram1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1359100. Tram1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3231CytoplasmicSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 8128LumenalSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 12119CytoplasmicSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Topological domaini143 – 15917LumenalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 19212CytoplasmicSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Topological domaini214 – 2141LumenalSequence analysis
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Topological domaini236 – 25116CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 29725LumenalSequence analysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence analysisAdd
BLAST
Topological domaini319 – 37456CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 374373Translocating chain-associated membrane protein 1PRO_0000240445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Modified residuei365 – 3651PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5XI41.
PRIDEiQ5XI41.

PTM databases

iPTMnetiQ5XI41.

Expressioni

Gene expression databases

ExpressionAtlasiQ5XI41. baseline and differential.
GenevisibleiQ5XI41. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4580535.
STRINGi10116.ENSRNOP00000045166.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 326210TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAM family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
GeneTreeiENSGT00510000046470.
HOGENOMiHOG000007494.
HOVERGENiHBG054402.
InParanoidiQ5XI41.
KOiK14010.
OMAiLQLAYWF.
OrthoDBiEOG7ZPNKC.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRKKSNKN PPVLSHEFVL QNHADIVSCL AMLFLLGLMF EITAKGAIIF
60 70 80 90 100
VALQYNVTRP ATEEQAAESA SLYYYGIKDL ATVFFYMLVA IIVHAIIQEY
110 120 130 140 150
VLDKINRRMH FSKTKHSKFN ESGQLSAFYL FACVWGTFIL VSENYISDPT
160 170 180 190 200
ILWRAYPHNL MTFQMKFFYI SQLAYWLHAF PELYFQKTKK EDIPRQLVYI
210 220 230 240 250
GLYLFHIAGA YLLNLNHLGL VLLVLHYFVE FLFHISRLFY FSDEKYQKGF
260 270 280 290 300
SLWAVLFVLG RLLTLILSVL TVGFGLARAE NQKLDFSTGN FNVLAVRIAV
310 320 330 340 350
LASICITQAF MMWKFINFQL RRWREHSAFQ APPVKRKPAV TKGRSSRKGT
360 370
ENGVNGTVTS NGADSPRSRK EKSS
Length:374
Mass (Da):43,030
Last modified:January 23, 2007 - v3
Checksum:i14889B19E79BDBA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083851 mRNA. Translation: AAH83851.1.
RefSeqiNP_001007702.1. NM_001007701.1.
UniGeneiRn.234346.

Genome annotation databases

EnsembliENSRNOT00000010481; ENSRNOP00000010481; ENSRNOG00000007892.
GeneIDi312903.
KEGGirno:312903.
UCSCiRGD:1359100. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083851 mRNA. Translation: AAH83851.1.
RefSeqiNP_001007702.1. NM_001007701.1.
UniGeneiRn.234346.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4580535.
STRINGi10116.ENSRNOP00000045166.

PTM databases

iPTMnetiQ5XI41.

Proteomic databases

PaxDbiQ5XI41.
PRIDEiQ5XI41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010481; ENSRNOP00000010481; ENSRNOG00000007892.
GeneIDi312903.
KEGGirno:312903.
UCSCiRGD:1359100. rat.

Organism-specific databases

CTDi23471.
RGDi1359100. Tram1.

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
GeneTreeiENSGT00510000046470.
HOGENOMiHOG000007494.
HOVERGENiHBG054402.
InParanoidiQ5XI41.
KOiK14010.
OMAiLQLAYWF.
OrthoDBiEOG7ZPNKC.

Miscellaneous databases

PROiQ5XI41.

Gene expression databases

ExpressionAtlasiQ5XI41. baseline and differential.
GenevisibleiQ5XI41. RN.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRAM1_RAT
AccessioniPrimary (citable) accession number: Q5XI41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.