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Protein

Translocating chain-associated membrane protein 1

Gene

Tram1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulatory or required for the translocation of secretory proteins across the ER membrane.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane protein 1
Gene namesi
Name:Tram1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1359100. Tram1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 32CytoplasmicSequence analysisAdd BLAST31
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 81LumenalSequence analysisAdd BLAST28
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 121CytoplasmicSequence analysisAdd BLAST19
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 159LumenalSequence analysisAdd BLAST17
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 192CytoplasmicSequence analysisAdd BLAST12
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214LumenalSequence analysis1
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 251CytoplasmicSequence analysisAdd BLAST16
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 297LumenalSequence analysisAdd BLAST25
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 374CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002404452 – 374Translocating chain-associated membrane protein 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Modified residuei365PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5XI41.
PRIDEiQ5XI41.

PTM databases

iPTMnetiQ5XI41.
PhosphoSitePlusiQ5XI41.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007892.
ExpressionAtlasiQ5XI41. baseline and differential.
GenevisibleiQ5XI41. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4580535.
STRINGi10116.ENSRNOP00000045166.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 326TLCPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the TRAM family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
GeneTreeiENSGT00510000046470.
HOGENOMiHOG000007494.
HOVERGENiHBG054402.
InParanoidiQ5XI41.
KOiK14010.
OMAiLQLAYWF.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRKKSNKN PPVLSHEFVL QNHADIVSCL AMLFLLGLMF EITAKGAIIF
60 70 80 90 100
VALQYNVTRP ATEEQAAESA SLYYYGIKDL ATVFFYMLVA IIVHAIIQEY
110 120 130 140 150
VLDKINRRMH FSKTKHSKFN ESGQLSAFYL FACVWGTFIL VSENYISDPT
160 170 180 190 200
ILWRAYPHNL MTFQMKFFYI SQLAYWLHAF PELYFQKTKK EDIPRQLVYI
210 220 230 240 250
GLYLFHIAGA YLLNLNHLGL VLLVLHYFVE FLFHISRLFY FSDEKYQKGF
260 270 280 290 300
SLWAVLFVLG RLLTLILSVL TVGFGLARAE NQKLDFSTGN FNVLAVRIAV
310 320 330 340 350
LASICITQAF MMWKFINFQL RRWREHSAFQ APPVKRKPAV TKGRSSRKGT
360 370
ENGVNGTVTS NGADSPRSRK EKSS
Length:374
Mass (Da):43,030
Last modified:January 23, 2007 - v3
Checksum:i14889B19E79BDBA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083851 mRNA. Translation: AAH83851.1.
RefSeqiNP_001007702.1. NM_001007701.1.
UniGeneiRn.234346.

Genome annotation databases

EnsembliENSRNOT00000010481; ENSRNOP00000010481; ENSRNOG00000007892.
GeneIDi312903.
KEGGirno:312903.
UCSCiRGD:1359100. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083851 mRNA. Translation: AAH83851.1.
RefSeqiNP_001007702.1. NM_001007701.1.
UniGeneiRn.234346.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4580535.
STRINGi10116.ENSRNOP00000045166.

PTM databases

iPTMnetiQ5XI41.
PhosphoSitePlusiQ5XI41.

Proteomic databases

PaxDbiQ5XI41.
PRIDEiQ5XI41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010481; ENSRNOP00000010481; ENSRNOG00000007892.
GeneIDi312903.
KEGGirno:312903.
UCSCiRGD:1359100. rat.

Organism-specific databases

CTDi23471.
RGDi1359100. Tram1.

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
GeneTreeiENSGT00510000046470.
HOGENOMiHOG000007494.
HOVERGENiHBG054402.
InParanoidiQ5XI41.
KOiK14010.
OMAiLQLAYWF.

Miscellaneous databases

PROiQ5XI41.

Gene expression databases

BgeeiENSRNOG00000007892.
ExpressionAtlasiQ5XI41. baseline and differential.
GenevisibleiQ5XI41. RN.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRAM1_RAT
AccessioniPrimary (citable) accession number: Q5XI41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.