Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GPI transamidase component PIG-S

Gene

Pigs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-162791. Attachment of GPI anchor to uPAR.
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI transamidase component PIG-S
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class S protein
Gene namesi
Name:Pigs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359436. Pigs.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 520LumenalSequence analysisAdd BLAST481
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 555CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186061 – 555GPI transamidase component PIG-SAdd BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5XI31.
PRIDEiQ5XI31.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011366.
GenevisibleiQ5XI31. RN.

Interactioni

Subunit structurei

Forms a complex with PIGK/GPI8, PIGT, PIGU and GAA1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015207.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2459. Eukaryota.
ENOG410XR9U. LUCA.
GeneTreeiENSGT00390000017203.
HOGENOMiHOG000067980.
HOVERGENiHBG031822.
InParanoidiQ5XI31.
KOiK05291.
OMAiKYKMKIK.
OrthoDBiEOG091G06XK.
PhylomeDBiQ5XI31.
TreeFamiTF105857.

Family and domain databases

InterProiView protein in InterPro
IPR019540. PtdIno-glycan_biosynth_class_S.
PANTHERiPTHR21072. PTHR21072. 1 hit.
PfamiView protein in Pfam
PF10510. PIG-S. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XI31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGAAATD LEVVRGKRAA LFFAAVAILL GLPLWWKTTE TYRAPLPYSE
60 70 80 90 100
ISGLNALQLR LMVPVTVVFT RDSVPLDDQE KLPFTVVHER EIPLKYKMKI
110 120 130 140 150
KCRFQKAYRR ALEHEEEALS LGSVHEAEAL LAEPEKQAEG SLTVYVISEH
160 170 180 190 200
SSLLPQDMMS YIGPERTAIV RGMIHREAFN IIGRRIIHVA QAMSLTEDVL
210 220 230 240 250
AAALADHLPE DKWSSDKRRP LKSSLGYEIT FSLLNPDPKS HDVHWDIEEG
260 270 280 290 300
VQRYVQPFLN RLSAAGNFSV DSQILYYAML GVNPRFDPAS SSYSLAMHSL
310 320 330 340 350
PHVINPVESR LGSSAASLYP VLNFLLYVPE LAHSPLYIQD KDGAPVATNA
360 370 380 390 400
FHSPRWGGIM VYNVDPKIYN ASELPVRVEV DMAQVMEVFL AQLRLLFGIA
410 420 430 440 450
QPQVPPKCLL SGPKSEGLMT WELDRLLWAR SVENLATATT TLTSLAQLLG
460 470 480 490 500
KISNIVIKDD VASEVYRAVA AVQKAAEALA LGHLSSAFAA SQEAVTSSER
510 520 530 540 550
AFFDPSLLHL LYFPDDQKFA IYIPLFLPMA VPILLSLVKI FLETHKSWKK

PEKID
Length:555
Mass (Da):61,724
Last modified:January 23, 2007 - v3
Checksum:iA3FF73CA93F6A0AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083862 mRNA. Translation: AAH83862.1.
RefSeqiNP_001006602.1. NM_001006602.1.
UniGeneiRn.59136.

Genome annotation databases

EnsembliENSRNOT00000015207; ENSRNOP00000015207; ENSRNOG00000011366.
GeneIDi303277.
KEGGirno:303277.

Similar proteinsi

Entry informationi

Entry nameiPIGS_RAT
AccessioniPrimary (citable) accession number: Q5XI31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families