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Protein

Cleavage and polyadenylation specificity factor subunit 7

Gene

Cpsf7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Binds to cleavage and polyadenylation RNA substrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-72163. mRNA Splicing - Major Pathway.
R-RNO-72187. mRNA 3'-end processing.
R-RNO-77595. Processing of Intronless Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 7
Gene namesi
Name:Cpsf7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305441. Cpsf7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Cleavage and polyadenylation specificity factor subunit 7PRO_0000081529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941PhosphothreonineCombined sources
Modified residuei196 – 1961PhosphoserineBy similarity
Modified residuei404 – 4041PhosphoserineBy similarity
Modified residuei414 – 4141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XI29.
PRIDEiQ5XI29.

PTM databases

iPTMnetiQ5XI29.

Expressioni

Gene expression databases

GenevisibleiQ5XI29. RN.

Interactioni

Subunit structurei

Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028074.

Structurei

3D structure databases

ProteinModelPortaliQ5XI29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 16281RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 544Poly-Pro
Compositional biasi209 – 29890Pro-richAdd
BLAST
Compositional biasi409 – 46052Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM CPSF6/7 family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4849. Eukaryota.
ENOG4111NBM. LUCA.
GeneTreeiENSGT00730000110905.
HOGENOMiHOG000111137.
HOVERGENiHBG056699.
InParanoidiQ5XI29.
KOiK14398.
OMAiNADQMDL.
OrthoDBiEOG74TX09.
PhylomeDBiQ5XI29.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGVDLIDI YADEEFNQDS EFNNTDQIDL YDDVLTAASQ PSDDRSSSTE
60 70 80 90 100
PPPPVRQEPA PKPNNKTPAI LYTYSGLRSR RAAVYVGSFS WWTTDQQLIQ
110 120 130 140 150
VIRSIGVYDV VELKFAENRA NGQSKGYAEV VVASENSVHK LLELLPGKVL
160 170 180 190 200
NGEKVDVRPA TRQNLSQFEA QARKRIPPRA HSRDSSDSAD GRATPSENLV
210 220 230 240 250
PSSARVDKPP SVLPYFNRPP SALPLMGLPP PPIPPPPPLS SSFGVPPPPP
260 270 280 290 300
GIHYQHLMPP PPRLPPHLAV PPPGAIPPAL HLNPAFFPPP NATVGPPPDT
310 320 330 340 350
YMKASTPYNH HGSRDSGPLP STVSEAEFEE IMKRNRAISS SAISKAVSGA
360 370 380 390 400
SAGDYSDAIE TLLTAIAVIK QSRVANDERC RVLISSLKDC LHGIEAKSYS
410 420 430 440 450
VGASGSSSRK RHRSRERSPS RSRESSRRHR DLLHNEDRHD DYFQERNREH
460
ERHRDRERDR HH
Length:462
Mass (Da):51,073
Last modified:November 23, 2004 - v1
Checksum:i125D10ACC75A23C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083864 mRNA. Translation: AAH83864.1.
RefSeqiNP_001014267.1. NM_001014245.2.
XP_008758461.1. XM_008760239.1.
UniGeneiRn.98627.

Genome annotation databases

EnsembliENSRNOT00000028074; ENSRNOP00000028074; ENSRNOG00000020668.
GeneIDi365407.
KEGGirno:365407.
UCSCiRGD:1305441. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083864 mRNA. Translation: AAH83864.1.
RefSeqiNP_001014267.1. NM_001014245.2.
XP_008758461.1. XM_008760239.1.
UniGeneiRn.98627.

3D structure databases

ProteinModelPortaliQ5XI29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028074.

PTM databases

iPTMnetiQ5XI29.

Proteomic databases

PaxDbiQ5XI29.
PRIDEiQ5XI29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028074; ENSRNOP00000028074; ENSRNOG00000020668.
GeneIDi365407.
KEGGirno:365407.
UCSCiRGD:1305441. rat.

Organism-specific databases

CTDi79869.
RGDi1305441. Cpsf7.

Phylogenomic databases

eggNOGiKOG4849. Eukaryota.
ENOG4111NBM. LUCA.
GeneTreeiENSGT00730000110905.
HOGENOMiHOG000111137.
HOVERGENiHBG056699.
InParanoidiQ5XI29.
KOiK14398.
OMAiNADQMDL.
OrthoDBiEOG74TX09.
PhylomeDBiQ5XI29.

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-72163. mRNA Splicing - Major Pathway.
R-RNO-72187. mRNA 3'-end processing.
R-RNO-77595. Processing of Intronless Pre-mRNAs.

Miscellaneous databases

PROiQ5XI29.

Gene expression databases

GenevisibleiQ5XI29. RN.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCPSF7_RAT
AccessioniPrimary (citable) accession number: Q5XI29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.