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Q5XI22

- THIC_RAT

UniProt

Q5XI22 - THIC_RAT

Protein

Acetyl-CoA acetyltransferase, cytosolic

Gene

Acat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921Acyl-thioester intermediateBy similarity
    Active sitei353 – 3531Proton acceptorPROSITE-ProRule annotation
    Active sitei383 – 3831Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. acetyl-CoA C-acetyltransferase activity Source: RGD

    GO - Biological processi

    1. brain development Source: RGD
    2. cellular response to fatty acid Source: RGD
    3. cellular response to nutrient Source: RGD
    4. ketone body catabolic process Source: RGD
    5. liver development Source: RGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    SABIO-RKQ5XI22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA acetyltransferase, cytosolic (EC:2.3.1.9)
    Alternative name(s):
    Cytosolic acetoacetyl-CoA thiolase
    Gene namesi
    Name:Acat2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1359366. Acat2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Acetyl-CoA acetyltransferase, cytosolicPRO_0000271366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei200 – 2001N6-acetyllysineBy similarity
    Modified residuei233 – 2331N6-acetyllysineBy similarity
    Modified residuei235 – 2351N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5XI22.
    PRIDEiQ5XI22.

    PTM databases

    PhosphoSiteiQ5XI22.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XI22.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018934.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XI22.
    SMRiQ5XI22. Positions 4-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thiolase family.Curated

    Phylogenomic databases

    eggNOGiCOG0183.
    HOGENOMiHOG000012238.
    HOVERGENiHBG003112.
    InParanoidiQ5XI22.
    KOiK00626.

    Family and domain databases

    Gene3Di3.40.47.10. 4 hits.
    InterProiIPR002155. Thiolase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    IPR020610. Thiolase_AS.
    IPR020617. Thiolase_C.
    IPR020613. Thiolase_CS.
    IPR020616. Thiolase_N.
    [Graphical view]
    PfamiPF02803. Thiolase_C. 1 hit.
    PF00108. Thiolase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
    PROSITEiPS00737. THIOLASE_2. 1 hit.
    PS00099. THIOLASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XI22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAGSDPVVI ISAARTAIGS FNGALSTVPV HNLGTTVIKE VLQRAKVAPE    50
    EVSEVIFGHV LTAGCGQNPT RQASVGAGIP YSVPAWSCQM ICGSGLKAVC 100
    LAAQSIAMGD STIVVAGGME NMSKAPHLAH LRSGVKMGEV PLADSILCDG 150
    LTDAFHNYHM GITAENVAKK WQVSREAQDK VAVVSQNRAE HAQKAGHFDK 200
    EIVPVHVSSR KGLTEVKIDE FPRHGSNLEA MSKLKPYFLT DGTGTVTPAN 250
    ASGMNDGAAA VVLMKKTEAE SRMLKPLAQV VSWSQAGVEP SVMGVGPIPA 300
    IKQAVAKAGW SLEDVDVFEI NEAFAAVSAA IAKELGLSPE KVNIDGGAIA 350
    LGHPLGASGC RILVTLLHTL ERVGGTRGVA ALCIGGGMGI AMCVQRG 397
    Length:397
    Mass (Da):41,108
    Last modified:November 23, 2004 - v1
    Checksum:i850589DD5AF4D84F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083872 mRNA. Translation: AAH83872.1.
    RefSeqiNP_001006996.1. NM_001006995.1.
    UniGeneiRn.203063.

    Genome annotation databases

    GeneIDi308100.
    KEGGirno:308100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083872 mRNA. Translation: AAH83872.1 .
    RefSeqi NP_001006996.1. NM_001006995.1.
    UniGenei Rn.203063.

    3D structure databases

    ProteinModelPortali Q5XI22.
    SMRi Q5XI22. Positions 4-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018934.

    PTM databases

    PhosphoSitei Q5XI22.

    Proteomic databases

    PaxDbi Q5XI22.
    PRIDEi Q5XI22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 308100.
    KEGGi rno:308100.

    Organism-specific databases

    CTDi 39.
    RGDi 1359366. Acat2.

    Phylogenomic databases

    eggNOGi COG0183.
    HOGENOMi HOG000012238.
    HOVERGENi HBG003112.
    InParanoidi Q5XI22.
    KOi K00626.

    Enzyme and pathway databases

    SABIO-RK Q5XI22.

    Miscellaneous databases

    NextBioi 658342.
    PROi Q5XI22.

    Gene expression databases

    Genevestigatori Q5XI22.

    Family and domain databases

    Gene3Di 3.40.47.10. 4 hits.
    InterProi IPR002155. Thiolase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    IPR020610. Thiolase_AS.
    IPR020617. Thiolase_C.
    IPR020613. Thiolase_CS.
    IPR020616. Thiolase_N.
    [Graphical view ]
    Pfami PF02803. Thiolase_C. 1 hit.
    PF00108. Thiolase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
    PROSITEi PS00737. THIOLASE_2. 1 hit.
    PS00099. THIOLASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 16-39; 195-210; 218-223 AND 342-372, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Hippocampus and Spinal cord.

    Entry informationi

    Entry nameiTHIC_RAT
    AccessioniPrimary (citable) accession number: Q5XI22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3