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Protein

Acetyl-CoA acetyltransferase, cytosolic

Gene

Acat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Acyl-thioester intermediateBy similarity1
Active sitei353Proton acceptorPROSITE-ProRule annotation1
Active sitei383Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • acetyl-CoA C-acetyltransferase activity Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • cellular response to fatty acid Source: RGD
  • cellular response to nutrient Source: RGD
  • cholesterol biosynthetic process Source: UniProtKB
  • dolichol biosynthetic process Source: UniProtKB
  • fatty acid beta-oxidation Source: GO_Central
  • ketone body catabolic process Source: RGD
  • liver development Source: RGD
  • positive regulation of intestinal cholesterol absorption Source: RGD

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

SABIO-RKiQ5XI22

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase, cytosolic (EC:2.3.1.9)
Alternative name(s):
Cytosolic acetoacetyl-CoA thiolase
Gene namesi
Name:Acat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359366 Acat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713661 – 397Acetyl-CoA acetyltransferase, cytosolicAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei200N6-acetyllysineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei235N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XI22
PRIDEiQ5XI22

PTM databases

iPTMnetiQ5XI22
PhosphoSitePlusiQ5XI22

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059561

Structurei

3D structure databases

ProteinModelPortaliQ5XI22
SMRiQ5XI22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiKOG1391 Eukaryota
COG0183 LUCA
HOGENOMiHOG000012238
HOVERGENiHBG003112
InParanoidiQ5XI22
KOiK00626

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.104 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XI22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAGSDPVVI ISAARTAIGS FNGALSTVPV HNLGTTVIKE VLQRAKVAPE
60 70 80 90 100
EVSEVIFGHV LTAGCGQNPT RQASVGAGIP YSVPAWSCQM ICGSGLKAVC
110 120 130 140 150
LAAQSIAMGD STIVVAGGME NMSKAPHLAH LRSGVKMGEV PLADSILCDG
160 170 180 190 200
LTDAFHNYHM GITAENVAKK WQVSREAQDK VAVVSQNRAE HAQKAGHFDK
210 220 230 240 250
EIVPVHVSSR KGLTEVKIDE FPRHGSNLEA MSKLKPYFLT DGTGTVTPAN
260 270 280 290 300
ASGMNDGAAA VVLMKKTEAE SRMLKPLAQV VSWSQAGVEP SVMGVGPIPA
310 320 330 340 350
IKQAVAKAGW SLEDVDVFEI NEAFAAVSAA IAKELGLSPE KVNIDGGAIA
360 370 380 390
LGHPLGASGC RILVTLLHTL ERVGGTRGVA ALCIGGGMGI AMCVQRG
Length:397
Mass (Da):41,108
Last modified:November 23, 2004 - v1
Checksum:i850589DD5AF4D84F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083872 mRNA Translation: AAH83872.1
RefSeqiNP_001006996.1, NM_001006995.1
UniGeneiRn.203063

Genome annotation databases

GeneIDi308100
KEGGirno:308100

Similar proteinsi

Entry informationi

Entry nameiTHIC_RAT
AccessioniPrimary (citable) accession number: Q5XI22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 23, 2004
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome