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Protein

Glutamate-rich WD repeat-containing protein 1

Gene

Grwd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich WD repeat-containing protein 1
Gene namesi
Name:Grwd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310649. Grwd1.

Subcellular locationi

  • Nucleusnucleolus By similarity
  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510131 – 445Glutamate-rich WD repeat-containing protein 1Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphothreonineBy similarity1
Modified residuei119PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XI13.
PRIDEiQ5XI13.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021058.
GenevisibleiQ5XI13. RN.

Interactioni

Subunit structurei

Interacts with METTL18. Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1. Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6. Binds to histone H2A-H2B and H3-H4 complexes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053027.

Structurei

3D structure databases

ProteinModelPortaliQ5XI13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati211 – 251WD 1Add BLAST41
Repeati258 – 298WD 2Add BLAST41
Repeati305 – 344WD 3Add BLAST40
Repeati350 – 390WD 4Add BLAST41
Repeati411 – 444WD 5Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi123 – 135Asp/Glu-rich (acidic)Add BLAST13

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0302. Eukaryota.
ENOG410XPDB. LUCA.
HOGENOMiHOG000036730.
HOVERGENiHBG051847.
InParanoidiQ5XI13.
KOiK14848.
OrthoDBiEOG091G07FI.
PhylomeDBiQ5XI13.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 3 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 4 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XI13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARKGRRHT CETGEPMEAE TYDLGSEGPS QVYLPGRGPP LGEGEELVMD
60 70 80 90 100
EEAYVLYHRA QTGAPCLSFD IVRDHLGDNR TELPLSLYLC AGTQAESAQS
110 120 130 140 150
NRLMMLRMHN LHGTRPPPSE GSDDEDDEDE EDEEERKPQL ELAMVPHYGG
160 170 180 190 200
INRVRVSWLG EEPVAGVWSE KGQVEVFALR RLLQVVDDPQ ALAIFLRDEQ
210 220 230 240 250
ARVKPIFSFA GHMGEGFALD WSPRVPGRLL TGDCQKNIHL WTPTDGGSWN
260 270 280 290 300
VDQRPFVGHT RSVEDLQWSP TEDTVFASCS ADASIRIWDI RAAPGKACML
310 320 330 340 350
TTAAAHDGDV NVISWSRREP FLLSGGDDGT LKVWDLRQFK SGSPVATFKQ
360 370 380 390 400
HVAPVTSVEW HPQDSGVFAA SGADNQITQW DLAVERDPES GETETDPGLA
410 420 430 440
ALPQQLLFVH QGETDLKELH WHPQCPGVLI STALSGFTVF RTISV
Length:445
Mass (Da):49,169
Last modified:November 23, 2004 - v1
Checksum:iAF6653A73976A0B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083883 mRNA. Translation: AAH83883.1.
RefSeqiNP_001012067.1. NM_001012067.1.
UniGeneiRn.33523.

Genome annotation databases

GeneIDi308592.
KEGGirno:308592.
UCSCiRGD:1310649. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083883 mRNA. Translation: AAH83883.1.
RefSeqiNP_001012067.1. NM_001012067.1.
UniGeneiRn.33523.

3D structure databases

ProteinModelPortaliQ5XI13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053027.

Proteomic databases

PaxDbiQ5XI13.
PRIDEiQ5XI13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi308592.
KEGGirno:308592.
UCSCiRGD:1310649. rat.

Organism-specific databases

CTDi83743.
RGDi1310649. Grwd1.

Phylogenomic databases

eggNOGiKOG0302. Eukaryota.
ENOG410XPDB. LUCA.
HOGENOMiHOG000036730.
HOVERGENiHBG051847.
InParanoidiQ5XI13.
KOiK14848.
OrthoDBiEOG091G07FI.
PhylomeDBiQ5XI13.

Miscellaneous databases

PROiPR:Q5XI13.

Gene expression databases

BgeeiENSRNOG00000021058.
GenevisibleiQ5XI13. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 3 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 4 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRWD1_RAT
AccessioniPrimary (citable) accession number: Q5XI13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 23, 2004
Last modified: May 10, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.