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Protein

Lipoma-preferred partner homolog

Gene

Lpp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma-preferred partner homolog
Gene namesi
Name:Lpp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1310535. Lpp.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cell junction By similarity

  • Note: Found in the nucleus, in the cytoplasm and at cell adhesion sites.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Lipoma-preferred partner homologPRO_0000075834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-acetyllysineBy similarity
Modified residuei117 – 1171PhosphoserineCombined sources
Modified residuei152 – 1521PhosphoserineCombined sources
Modified residuei241 – 2411PhosphotyrosineBy similarity
Cross-linki324 – 324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5XI07.
PeptideAtlasiQ5XI07.
PRIDEiQ5XI07.

PTM databases

iPTMnetiQ5XI07.
PhosphoSiteiQ5XI07.

Expressioni

Gene expression databases

BgeeiENSRNOG00000031669.
GenevisibleiQ5XI07. RN.

Interactioni

Subunit structurei

Interacts with PDZ domains of SCRIB, with VASP and with ACTN1/alpha-actinin.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042917.

Structurei

3D structure databases

ProteinModelPortaliQ5XI07.
SMRiQ5XI07. Positions 441-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 49360LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 55461LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini555 – 62369LIM zinc-binding 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 204164Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated
Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
HOVERGENiHBG093602.
InParanoidiQ5XI07.
KOiK16676.
OMAiICAGCHE.
OrthoDBiEOG091G085F.
PhylomeDBiQ5XI07.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR028771. LPP.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24207:SF0. PTHR24207:SF0. 3 hits.
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPSWLPPR STGEPLGHVP ARMETTHSFG TPSISVSTQQ PPKKFAPVVA
60 70 80 90 100
PKPKYNPYKQ PGGEGDFLPP PPPPLEDPGT IPSGSGHFPP PPPLDEGAFI
110 120 130 140 150
VQRGNPGGKT LEERRSSLDA EIDSLTSILA DLECSSPYKP RAPPGSSSSI
160 170 180 190 200
ASPPVSTPVT GHKRMVIPQQ PPLTATKKSA TKPQAIPIPV TPIGTLKPQP
210 220 230 240 250
QPVPASYSTA STSSRPAFNV QVKSAQPSTH YMTGSSSGQM YGPGSRSYNT
260 270 280 290 300
QQVPLSAQCP PPTTCAGTDY AYIPPSGQQA ESGFGYTSNQ GRYFEPFFAA
310 320 330 340 350
CPSYGGRNEA DPAYGQQVQP NTWKREPGYA APGAGNQNQP GMYSVSGPKK
360 370 380 390 400
TYITDPVSAP CAPPVQPKER LVKNQKVLQN VVDDRVHGLR KSGFPAPMGP
410 420 430 440 450
PSVPPSFRPE DELEHLTKKM LYDMENPPAD DYFGRCARCG ENVVGEGTGC
460 470 480 490 500
TAMDQVFHVD CFTCMVCDIK LRGQPFYAVE KKAYCEPCYI NTLEQCSVCS
510 520 530 540 550
KPIMERILRA TGKAYHPHCF TCVMCHRSLD GIPFTVDACG LIHCIEDFHK
560 570 580 590 600
KFAPRCSVCK EPIMPAPGQE ETVRIVALDR DFHVHCYRCE DCGGLLSEGD
610 620 630
NQGCYPLDGH ILCKSCNSAR IRVLTAKAST DL
Length:632
Mass (Da):68,260
Last modified:November 23, 2004 - v1
Checksum:i8539C27B5D7D02BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083627 mRNA. Translation: AAH83627.1.
BC083890 mRNA. Translation: AAH83890.1.
RefSeqiNP_001013886.1. NM_001013864.1.
XP_006248567.1. XM_006248505.2.
UniGeneiRn.206503.

Genome annotation databases

EnsembliENSRNOT00000044279; ENSRNOP00000042917; ENSRNOG00000031669.
GeneIDi288010.
KEGGirno:288010.
UCSCiRGD:1310535. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083627 mRNA. Translation: AAH83627.1.
BC083890 mRNA. Translation: AAH83890.1.
RefSeqiNP_001013886.1. NM_001013864.1.
XP_006248567.1. XM_006248505.2.
UniGeneiRn.206503.

3D structure databases

ProteinModelPortaliQ5XI07.
SMRiQ5XI07. Positions 441-553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042917.

PTM databases

iPTMnetiQ5XI07.
PhosphoSiteiQ5XI07.

Proteomic databases

PaxDbiQ5XI07.
PeptideAtlasiQ5XI07.
PRIDEiQ5XI07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044279; ENSRNOP00000042917; ENSRNOG00000031669.
GeneIDi288010.
KEGGirno:288010.
UCSCiRGD:1310535. rat.

Organism-specific databases

CTDi4026.
RGDi1310535. Lpp.

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
HOVERGENiHBG093602.
InParanoidiQ5XI07.
KOiK16676.
OMAiICAGCHE.
OrthoDBiEOG091G085F.
PhylomeDBiQ5XI07.

Miscellaneous databases

PROiQ5XI07.

Gene expression databases

BgeeiENSRNOG00000031669.
GenevisibleiQ5XI07. RN.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR028771. LPP.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24207:SF0. PTHR24207:SF0. 3 hits.
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPP_RAT
AccessioniPrimary (citable) accession number: Q5XI07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.