Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5XI02

- PDILT_RAT

UniProt

Q5XI02 - PDILT_RAT

Protein

Protein disulfide-isomerase-like protein of the testis

Gene

Pdilt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable redox-inactive chaperone involved in spermatogenesis.By similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cell redox homeostasis Source: InterPro
    3. multicellular organismal development Source: UniProtKB-KW
    4. protein folding Source: RefGenome
    5. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone, Developmental protein, Isomerase

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase-like protein of the testis
    Gene namesi
    Name:Pdilt
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1307822. Pdilt.

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 590570Protein disulfide-isomerase-like protein of the testisPRO_0000325852Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ5XI02.

    PTM databases

    PhosphoSiteiQ5XI02.

    Expressioni

    Tissue specificityi

    Testis-specific. Expressed exclusively in postmeiotic male germ cells (at protein level).1 Publication

    Developmental stagei

    Induced during puberty.1 Publication

    Gene expression databases

    GenevestigatoriQ5XI02.

    Interactioni

    Subunit structurei

    Homodimer. The homodimer is not disulfide-linked. Interacts with ERO1L and CLGN By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020817.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XI02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini385 – 44864ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi587 – 5904Prevents secretion from ERPROSITE-ProRule annotation

    Domaini

    The thioredoxin domain lacks the conserved redox-active Cys at position 414 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00740000115202.
    HOGENOMiHOG000115479.
    HOVERGENiHBG108240.
    InParanoidiQ5XI02.
    OMAiQKAFLFN.
    OrthoDBiEOG7VHSX1.
    PhylomeDBiQ5XI02.
    TreeFamiTF106381.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5XI02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLWTPLLL LAACLSEVLG SPEMDTGINI SQPLHILEDH NLMVLTPAGL    50
    TQTLNETRFL MVIFHNPTLK QSRKLAKELG KAAEIFGKGK NGLGFGKVDI 100
    TMETELKQEF DITHAPELKL FYEGNRLEPI SCKDVVESTA LVVWLRRQIS 150
    KKALLFNNSN EVADFVKSRP LVIVGFFQDL EEEVAELFYD TIKDFPELTF 200
    GAIQIKNSFG RFHVILDSVL VFKKGRVVKR QELINDSTNK DYLNQVIKQQ 250
    LTGFVIEFNP ENKDLIYEMN ILNHMLLFIS KNSEPYSTII RHYRQISKEF 300
    QNKILFVLVN SDEPKNKRIF EYFQISRVNV PSVQILNLSS DARYKMPTDN 350
    ITFESLKKFC NSFLSRTAKK HKSSEEIPKY WDQEPVKKLV GKNFNVVVFD 400
    KEKDVFVMFY APWSEKCRVL LPLLEELGIK YQNHSTVIIA KIDITANDIQ 450
    LANPEQYPFF RLFPTDSQEA VMYKGEHTMK GFCDFLESHV KVRIEEDDEL 500
    LYIEQNEVAE EEVLAEPEMQ HIDKLPEKPP LKVEDTSKQD RPAKESPALG 550
    SISQPEELER RKETAEKEKK VAQPKEQPKP ERKLDIKEEL 590
    Length:590
    Mass (Da):68,267
    Last modified:November 23, 2004 - v1
    Checksum:i6F73FA1B8CD304DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083897 mRNA. Translation: AAH83897.1.
    RefSeqiNP_001013924.1. NM_001013902.1.
    UniGeneiRn.146183.

    Genome annotation databases

    EnsembliENSRNOT00000020817; ENSRNOP00000020817; ENSRNOG00000015368.
    GeneIDi293544.
    KEGGirno:293544.
    UCSCiRGD:1307822. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083897 mRNA. Translation: AAH83897.1 .
    RefSeqi NP_001013924.1. NM_001013902.1.
    UniGenei Rn.146183.

    3D structure databases

    ProteinModelPortali Q5XI02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020817.

    PTM databases

    PhosphoSitei Q5XI02.

    Proteomic databases

    PRIDEi Q5XI02.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020817 ; ENSRNOP00000020817 ; ENSRNOG00000015368 .
    GeneIDi 293544.
    KEGGi rno:293544.
    UCSCi RGD:1307822. rat.

    Organism-specific databases

    CTDi 204474.
    RGDi 1307822. Pdilt.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00740000115202.
    HOGENOMi HOG000115479.
    HOVERGENi HBG108240.
    InParanoidi Q5XI02.
    OMAi QKAFLFN.
    OrthoDBi EOG7VHSX1.
    PhylomeDBi Q5XI02.
    TreeFami TF106381.

    Miscellaneous databases

    NextBioi 636364.

    Gene expression databases

    Genevestigatori Q5XI02.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells."
      van Lith M., Karala A.R., Bown D., Gatehouse J.A., Ruddock L.W., Saunders P.T.K., Benham A.M.
      Mol. Biol. Cell 18:2795-2804(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPDILT_RAT
    AccessioniPrimary (citable) accession number: Q5XI02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3