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Protein

Protein disulfide-isomerase-like protein of the testis

Gene

Pdilt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable redox-inactive chaperone involved in spermatogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein, Isomerase
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein of the testis
Gene namesi
Name:Pdilt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307822 Pdilt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000032585221 – 590Protein disulfide-isomerase-like protein of the testisAdd BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5XI02
PRIDEiQ5XI02

PTM databases

iPTMnetiQ5XI02
PhosphoSitePlusiQ5XI02

Expressioni

Tissue specificityi

Testis-specific. Expressed exclusively in postmeiotic male germ cells (at protein level).1 Publication

Developmental stagei

Induced during puberty.1 Publication

Gene expression databases

BgeeiENSRNOG00000015368

Interactioni

Subunit structurei

Homodimer. The homodimer is not disulfide-linked. Interacts with ERO1A and CLGN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020817

Structurei

3D structure databases

ProteinModelPortaliQ5XI02
SMRiQ5XI02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini385 – 448ThioredoxinPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi587 – 590Prevents secretion from ERPROSITE-ProRule annotation4

Domaini

The thioredoxin domain lacks the conserved redox-active Cys at position 414 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000115479
HOVERGENiHBG108240
InParanoidiQ5XI02
KOiK20354
OMAiYFRITEV
OrthoDBiEOG091G0B2I
PhylomeDBiQ5XI02
TreeFamiTF106381

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XI02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLWTPLLL LAACLSEVLG SPEMDTGINI SQPLHILEDH NLMVLTPAGL
60 70 80 90 100
TQTLNETRFL MVIFHNPTLK QSRKLAKELG KAAEIFGKGK NGLGFGKVDI
110 120 130 140 150
TMETELKQEF DITHAPELKL FYEGNRLEPI SCKDVVESTA LVVWLRRQIS
160 170 180 190 200
KKALLFNNSN EVADFVKSRP LVIVGFFQDL EEEVAELFYD TIKDFPELTF
210 220 230 240 250
GAIQIKNSFG RFHVILDSVL VFKKGRVVKR QELINDSTNK DYLNQVIKQQ
260 270 280 290 300
LTGFVIEFNP ENKDLIYEMN ILNHMLLFIS KNSEPYSTII RHYRQISKEF
310 320 330 340 350
QNKILFVLVN SDEPKNKRIF EYFQISRVNV PSVQILNLSS DARYKMPTDN
360 370 380 390 400
ITFESLKKFC NSFLSRTAKK HKSSEEIPKY WDQEPVKKLV GKNFNVVVFD
410 420 430 440 450
KEKDVFVMFY APWSEKCRVL LPLLEELGIK YQNHSTVIIA KIDITANDIQ
460 470 480 490 500
LANPEQYPFF RLFPTDSQEA VMYKGEHTMK GFCDFLESHV KVRIEEDDEL
510 520 530 540 550
LYIEQNEVAE EEVLAEPEMQ HIDKLPEKPP LKVEDTSKQD RPAKESPALG
560 570 580 590
SISQPEELER RKETAEKEKK VAQPKEQPKP ERKLDIKEEL
Length:590
Mass (Da):68,267
Last modified:November 23, 2004 - v1
Checksum:i6F73FA1B8CD304DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083897 mRNA Translation: AAH83897.1
RefSeqiNP_001013924.1, NM_001013902.1
UniGeneiRn.146183

Genome annotation databases

EnsembliENSRNOT00000020817; ENSRNOP00000020817; ENSRNOG00000015368
GeneIDi293544
KEGGirno:293544
UCSCiRGD:1307822 rat

Similar proteinsi

Entry informationi

Entry nameiPDILT_RAT
AccessioniPrimary (citable) accession number: Q5XI02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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