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Protein

La-related protein 7

Gene

Larp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 7
Alternative name(s):
La ribonucleoprotein domain family member 7
Gene namesi
Name:Larp7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1592474. Larp7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571La-related protein 7PRO_0000281679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei252 – 2521PhosphothreonineBy similarity
Modified residuei254 – 2541PhosphoserineCombined sources
Modified residuei257 – 2571PhosphoserineCombined sources
Modified residuei261 – 2611PhosphothreonineBy similarity
Modified residuei294 – 2941PhosphoserineBy similarity
Modified residuei295 – 2951PhosphoserineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei336 – 3361PhosphothreonineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XI01.
PRIDEiQ5XI01.

PTM databases

iPTMnetiQ5XI01.
PhosphoSiteiQ5XI01.

Interactioni

Subunit structurei

Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi601734. 1 interaction.
STRINGi10116.ENSRNOP00000065357.

Structurei

3D structure databases

ProteinModelPortaliQ5XI01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11795HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini120 – 19879RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 366170Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
HOVERGENiHBG081891.
InParanoidiQ5XI01.
KOiK15191.
PhylomeDBiQ5XI01.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XI01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METENQKTME ESTEKRKEEK KKRSRVKQVL ADIAKQVDFW FGDANLHKDR
60 70 80 90 100
FLREQIEKSR DGYVDISLLV SFNKMKKLTT DGKLIARALK SSSVVELDLE
110 120 130 140 150
GTRIRRKKPL GERPKDEEER TVYVELLPKN VTHSWIERVF GKCGNVVYIS
160 170 180 190 200
IPHYKSTGDP KGFAFVEFET KEQAAKAIEF LNNPPEEAPR KPGIFPKTVK
210 220 230 240 250
NKPIPSLRVA EEKKKKKKKK GRIKKEESVQ AKELVVDSSS SGVSKATKRP
260 270 280 290 300
RTASEGSEAE TPEAPKQPAK KKKKRDKVET GGLPESKAGK RERSSAEDED
310 320 330 340 350
CLPPRPKLKK RAQKDGGGPA ASEVSKEHRD LEFCSTEEEK EPGDRKGDSL
360 370 380 390 400
SKGKRKHKKK HKERHKMGEE VIPLRVLSKT EWMDLKKEYL ALQKASMASL
410 420 430 440 450
KKTISQIKLE SEMETESKAP PGSGQQCSTQ EKVSAQGPQF VTGVIVKILS
460 470 480 490 500
EDPLPGRKQV KDILATISEV VYIDLLEGDT ECHARFKTPE DAQAVMNAQT
510 520 530 540 550
EIKKKHSWNL EILSGDHEQR YWQKILVDRQ AKLNQPREKK RGTEKLITKA
560 570
EKIRLAKTQQ ASQHIRFSEY D
Length:571
Mass (Da):64,949
Last modified:March 20, 2007 - v2
Checksum:iEB52574AB7D6E330
GO

Sequence cautioni

The sequence AAH83898.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083898 mRNA. Translation: AAH83898.1. Different initiation.
RefSeqiNP_001037755.2. NM_001044290.2.
UniGeneiRn.79854.

Genome annotation databases

GeneIDi686883.
KEGGirno:686883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083898 mRNA. Translation: AAH83898.1. Different initiation.
RefSeqiNP_001037755.2. NM_001044290.2.
UniGeneiRn.79854.

3D structure databases

ProteinModelPortaliQ5XI01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi601734. 1 interaction.
STRINGi10116.ENSRNOP00000065357.

PTM databases

iPTMnetiQ5XI01.
PhosphoSiteiQ5XI01.

Proteomic databases

PaxDbiQ5XI01.
PRIDEiQ5XI01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi686883.
KEGGirno:686883.

Organism-specific databases

CTDi51574.
RGDi1592474. Larp7.

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
HOVERGENiHBG081891.
InParanoidiQ5XI01.
KOiK15191.
PhylomeDBiQ5XI01.

Miscellaneous databases

PROiQ5XI01.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 8-15; 347-354 AND 409-418, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254 AND SER-257, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLARP7_RAT
AccessioniPrimary (citable) accession number: Q5XI01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.