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Protein

Heat shock protein 75 kDa, mitochondrial

Gene

Trap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121ATPBy similarity1
Binding sitei160ATPBy similarity1
Binding sitei173ATPBy similarity1
Binding sitei207ATP; via amide nitrogenBy similarity1
Binding sitei404ATPBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase binding Source: ParkinsonsUK-UCL
  • RNA binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 75 kDa, mitochondrial
Short name:
HSP 75
Alternative name(s):
TNFR-associated protein 1
Tumor necrosis factor type 1 receptor-associated protein
Short name:
TRAP-1
Gene namesi
Name:Trap1
Synonyms:Hsp75
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359733 Trap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 60MitochondrionBy similarityAdd BLAST60
ChainiPRO_000027325061 – 706Heat shock protein 75 kDa, mitochondrialAdd BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineCombined sources1
Modified residuei176PhosphothreonineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei264N6-acetyllysineBy similarity1
Modified residuei326N6-acetyllysineBy similarity1
Modified residuei334N6-acetyllysineBy similarity1
Modified residuei426N6-acetyllysineBy similarity1
Modified residuei433N6-acetyllysineBy similarity1
Modified residuei468N6-acetyllysineBy similarity1
Modified residuei496PhosphothreonineBy similarity1
Modified residuei570PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XHZ0
PRIDEiQ5XHZ0

PTM databases

iPTMnetiQ5XHZ0
PhosphoSitePlusiQ5XHZ0

Expressioni

Gene expression databases

BgeeiENSRNOG00000005418
GenevisibleiQ5XHZ0 RN

Interactioni

Subunit structurei

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.By similarity

GO - Molecular functioni

  • protein kinase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: InterPro

Protein-protein interaction databases

IntActiQ5XHZ0, 1 interactor
MINTiQ5XHZ0
STRINGi10116.ENSRNOP00000008966

Structurei

3D structure databases

ProteinModelPortaliQ5XHZ0
SMRiQ5XHZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
GeneTreeiENSGT00910000144050
HOGENOMiHOG000031987
HOVERGENiHBG103147
InParanoidiQ5XHZ0
KOiK09488
OMAiALYTRKV
OrthoDBiEOG091G03C9
PhylomeDBiQ5XHZ0
TreeFamiTF315234

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XHZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARELRALLL WGRGLQSALR APALAGVRRG KPVLHLQKTT VHFRDPTQSL
60 70 80 90 100
ASGISAGQLY STQAAEDKKE EALHSIISNT EAVQGSVSKH EFQAETKKLL
110 120 130 140 150
DIVARSLYSE KEVFIRELIS NASDALEKLR HKRVCEGQVL PEMEIHLQTD
160 170 180 190 200
AEKGTITIQD TGIGMTKEEL VSNLGTIARS GSKAFLEALQ HQAETSSRII
210 220 230 240 250
GQFGVGFYSA FMVADKVEVY SRPAAPESPG YQWLSDGSGV FEIAEASGVR
260 270 280 290 300
PGTKIIIHLK SDCKDFANES RVQDVVTKYS NFVSFPLYLN GRRINTLQAI
310 320 330 340 350
WMMDPKDISE FQHEEFYRYI AQAYDKPRFI LHYKTDAPLN IRSIFYVPEM
360 370 380 390 400
KPSMFDVSRE LGSSVALYSR KVLIQTKATD ILPKWLRFVR GVVDSEDIPL
410 420 430 440 450
NLSRELLQES ALIRKLRDVL QQRLIKFFID QSKKDAEKYA KFFEDYGLFM
460 470 480 490 500
REGIVTTAEQ DIKEDIAKLL RYESSALPAG QLTSLSDYAS RMQAGTRNIY
510 520 530 540 550
YLCAPNRHLA EHSPYYEAMK QKQTEVLFCY EQFDELTLLH LREFDKKKLI
560 570 580 590 600
SVETDIVVDH YKEEKFEDTS PAGERLSEKE TEELMAWMRN ALGSRVTNVK
610 620 630 640 650
VTFRLDTHPA MVTVLEMGAA RHFLRMQQLA KTQEERAQLL QPTLEINPRH
660 670 680 690 700
TLIKKLNQLR EREPELAQLL VDQIYENAMI AAGLVDDPRA MVGRLNDLLV

KALERH
Length:706
Mass (Da):80,461
Last modified:November 23, 2004 - v1
Checksum:iAE64073BAEE5681C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083909 mRNA Translation: AAH83909.1
RefSeqiNP_001034090.1, NM_001039001.1
UniGeneiRn.144695

Genome annotation databases

EnsembliENSRNOT00000008966; ENSRNOP00000008966; ENSRNOG00000005418
GeneIDi287069
KEGGirno:287069
UCSCiRGD:1359733 rat

Similar proteinsi

Entry informationi

Entry nameiTRAP1_RAT
AccessioniPrimary (citable) accession number: Q5XHZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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