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Protein

Heat shock protein 75 kDa, mitochondrial

Gene

Trap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211ATPBy similarity
Binding sitei160 – 1601ATPBy similarity
Binding sitei173 – 1731ATPBy similarity
Binding sitei207 – 2071ATP; via amide nitrogenBy similarity
Binding sitei404 – 4041ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: ParkinsonsUK-UCL
  • protein kinase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 75 kDa, mitochondrial
Short name:
HSP 75
Alternative name(s):
TNFR-associated protein 1
Tumor necrosis factor type 1 receptor-associated protein
Short name:
TRAP-1
Gene namesi
Name:Trap1
Synonyms:Hsp75
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359733. Trap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6060MitochondrionBy similarityAdd
BLAST
Chaini61 – 706646Heat shock protein 75 kDa, mitochondrialPRO_0000273250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721PhosphoserineCombined sources
Modified residuei176 – 1761PhosphothreonineCombined sources
Modified residuei196 – 1961PhosphoserineBy similarity
Modified residuei264 – 2641N6-acetyllysineBy similarity
Modified residuei326 – 3261N6-acetyllysineBy similarity
Modified residuei334 – 3341N6-acetyllysineBy similarity
Modified residuei426 – 4261N6-acetyllysineBy similarity
Modified residuei433 – 4331N6-acetyllysineBy similarity
Modified residuei468 – 4681N6-acetyllysineBy similarity
Modified residuei496 – 4961PhosphothreonineBy similarity
Modified residuei570 – 5701PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XHZ0.
PRIDEiQ5XHZ0.

PTM databases

iPTMnetiQ5XHZ0.
PhosphoSiteiQ5XHZ0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005418.
GenevisibleiQ5XHZ0. RN.

Interactioni

Subunit structurei

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.By similarity

GO - Molecular functioni

  • protein kinase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

IntActiQ5XHZ0. 1 interaction.
STRINGi10116.ENSRNOP00000008966.

Structurei

3D structure databases

ProteinModelPortaliQ5XHZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031987.
HOVERGENiHBG103147.
InParanoidiQ5XHZ0.
KOiK09488.
OMAiMLLTNMN.
OrthoDBiEOG091G03C9.
PhylomeDBiQ5XHZ0.
TreeFamiTF315234.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XHZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARELRALLL WGRGLQSALR APALAGVRRG KPVLHLQKTT VHFRDPTQSL
60 70 80 90 100
ASGISAGQLY STQAAEDKKE EALHSIISNT EAVQGSVSKH EFQAETKKLL
110 120 130 140 150
DIVARSLYSE KEVFIRELIS NASDALEKLR HKRVCEGQVL PEMEIHLQTD
160 170 180 190 200
AEKGTITIQD TGIGMTKEEL VSNLGTIARS GSKAFLEALQ HQAETSSRII
210 220 230 240 250
GQFGVGFYSA FMVADKVEVY SRPAAPESPG YQWLSDGSGV FEIAEASGVR
260 270 280 290 300
PGTKIIIHLK SDCKDFANES RVQDVVTKYS NFVSFPLYLN GRRINTLQAI
310 320 330 340 350
WMMDPKDISE FQHEEFYRYI AQAYDKPRFI LHYKTDAPLN IRSIFYVPEM
360 370 380 390 400
KPSMFDVSRE LGSSVALYSR KVLIQTKATD ILPKWLRFVR GVVDSEDIPL
410 420 430 440 450
NLSRELLQES ALIRKLRDVL QQRLIKFFID QSKKDAEKYA KFFEDYGLFM
460 470 480 490 500
REGIVTTAEQ DIKEDIAKLL RYESSALPAG QLTSLSDYAS RMQAGTRNIY
510 520 530 540 550
YLCAPNRHLA EHSPYYEAMK QKQTEVLFCY EQFDELTLLH LREFDKKKLI
560 570 580 590 600
SVETDIVVDH YKEEKFEDTS PAGERLSEKE TEELMAWMRN ALGSRVTNVK
610 620 630 640 650
VTFRLDTHPA MVTVLEMGAA RHFLRMQQLA KTQEERAQLL QPTLEINPRH
660 670 680 690 700
TLIKKLNQLR EREPELAQLL VDQIYENAMI AAGLVDDPRA MVGRLNDLLV

KALERH
Length:706
Mass (Da):80,461
Last modified:November 23, 2004 - v1
Checksum:iAE64073BAEE5681C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083909 mRNA. Translation: AAH83909.1.
RefSeqiNP_001034090.1. NM_001039001.1.
UniGeneiRn.144695.

Genome annotation databases

EnsembliENSRNOT00000008966; ENSRNOP00000008966; ENSRNOG00000005418.
GeneIDi287069.
KEGGirno:287069.
UCSCiRGD:1359733. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083909 mRNA. Translation: AAH83909.1.
RefSeqiNP_001034090.1. NM_001039001.1.
UniGeneiRn.144695.

3D structure databases

ProteinModelPortaliQ5XHZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5XHZ0. 1 interaction.
STRINGi10116.ENSRNOP00000008966.

PTM databases

iPTMnetiQ5XHZ0.
PhosphoSiteiQ5XHZ0.

Proteomic databases

PaxDbiQ5XHZ0.
PRIDEiQ5XHZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008966; ENSRNOP00000008966; ENSRNOG00000005418.
GeneIDi287069.
KEGGirno:287069.
UCSCiRGD:1359733. rat.

Organism-specific databases

CTDi10131.
RGDi1359733. Trap1.

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031987.
HOVERGENiHBG103147.
InParanoidiQ5XHZ0.
KOiK09488.
OMAiMLLTNMN.
OrthoDBiEOG091G03C9.
PhylomeDBiQ5XHZ0.
TreeFamiTF315234.

Miscellaneous databases

PROiQ5XHZ0.

Gene expression databases

BgeeiENSRNOG00000005418.
GenevisibleiQ5XHZ0. RN.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRAP1_RAT
AccessioniPrimary (citable) accession number: Q5XHZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.