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Protein

Signal transducing adapter molecule 2

Gene

Stam2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-182971. EGFR downregulation.
R-RNO-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducing adapter molecule 2
Short name:
STAM-2
Gene namesi
Name:Stam2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1311497. Stam2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Signal transducing adapter molecule 2PRO_0000190149Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XHY7.
PRIDEiQ5XHY7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000027447.

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033318.

Structurei

3D structure databases

ProteinModelPortaliQ5XHY7.
SMRiQ5XHY7. Positions 1-150, 196-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 144129VHSPROSITE-ProRule annotationAdd
BLAST
Domaini165 – 18420UIMPROSITE-ProRule annotationAdd
BLAST
Domaini202 – 26160SH3PROSITE-ProRule annotationAdd
BLAST
Domaini360 – 37718ITAMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2202Interaction with USP8By similarity
Regioni334 – 36835Interaction with HGSBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi54 – 6714PxVxL motifAdd
BLAST

Domaini

Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.

Sequence similaritiesi

Belongs to the STAM family.Curated
Contains 1 ITAM domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 UIM (ubiquitin-interacting motif) domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2199. Eukaryota.
ENOG410XTSY. LUCA.
GeneTreeiENSGT00700000104139.
HOGENOMiHOG000231952.
HOVERGENiHBG053175.
InParanoidiQ5XHY7.
KOiK04705.
OMAiYTQQMGM.
OrthoDBiEOG091G0H1Y.
PhylomeDBiQ5XHY7.
TreeFamiTF315007.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF02809. UIM. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00726. UIM. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XHY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDRVGSTP NGAKDCLKAI
60 70 80 90 100
MKRVNHKVPH VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK
110 120 130 140 150
AHPKVCEKLK SLMVEWSEEF QKDPQFSLIS ATIKAMKEEG VTFPSAGSQT
160 170 180 190 200
VSAAAKNGAS LNKNKEDEDI AKAIELSLQE QKQQYPETKA LCPPAESQLS
210 220 230 240 250
NKVARRVRAL YDFEAVEDNE LTFKHGEIIT VLDDSDANWW EGENHRGAGL
260 270 280 290 300
FPSSFVTTDL STEVEAATVD KSNVIDDDVE EIKKSEPEPV YIDEGKMDRA
310 320 330 340 350
LQILQSIDPK DPKPDSQDLL DLEDICQQMG PMIDEKLEEI DRRHSELSEL
360 370 380 390 400
NVKVLEALEL YNKLVNEAPM YSVYSKLHPA PYSATAAGVP VQTYPVQSHG
410 420 430 440 450
GNYLGHGIHQ VPVAQSYNLG PDPMGSSRSL PPNMNSVTAH TIQPPYLSTG
460 470 480 490 500
QDAVSNPSYM TQSSHLQAAA GTAAYTPAMG VSADLSSFQS TASGLPQLAG
510 520
FPVAVPVPPA PQPQASYHQQ PLL
Length:523
Mass (Da):57,159
Last modified:November 23, 2004 - v1
Checksum:i60D6910505391C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083912 mRNA. Translation: AAH83912.1.
RefSeqiNP_001012085.1. NM_001012085.1.
UniGeneiRn.161793.

Genome annotation databases

EnsembliENSRNOT00000037857; ENSRNOP00000033318; ENSRNOG00000027447.
GeneIDi311030.
KEGGirno:311030.
UCSCiRGD:1311497. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083912 mRNA. Translation: AAH83912.1.
RefSeqiNP_001012085.1. NM_001012085.1.
UniGeneiRn.161793.

3D structure databases

ProteinModelPortaliQ5XHY7.
SMRiQ5XHY7. Positions 1-150, 196-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033318.

Proteomic databases

PaxDbiQ5XHY7.
PRIDEiQ5XHY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037857; ENSRNOP00000033318; ENSRNOG00000027447.
GeneIDi311030.
KEGGirno:311030.
UCSCiRGD:1311497. rat.

Organism-specific databases

CTDi10254.
RGDi1311497. Stam2.

Phylogenomic databases

eggNOGiKOG2199. Eukaryota.
ENOG410XTSY. LUCA.
GeneTreeiENSGT00700000104139.
HOGENOMiHOG000231952.
HOVERGENiHBG053175.
InParanoidiQ5XHY7.
KOiK04705.
OMAiYTQQMGM.
OrthoDBiEOG091G0H1Y.
PhylomeDBiQ5XHY7.
TreeFamiTF315007.

Enzyme and pathway databases

ReactomeiR-RNO-182971. EGFR downregulation.
R-RNO-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

PROiQ5XHY7.

Gene expression databases

BgeeiENSRNOG00000027447.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF02809. UIM. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00726. UIM. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAM2_RAT
AccessioniPrimary (citable) accession number: Q5XHY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.