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Protein

Ecto-ADP-ribosyltransferase 5

Gene

Art5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NADBy similarity
Binding sitei161 – 1611NADBy similarity
Binding sitei181 – 1811NADBy similarity
Binding sitei215 – 2151NADBy similarity
Active sitei229 – 2291By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 5 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 5
Short name:
ARTC5
Mono(ADP-ribosyl)transferase 5
NAD(P)(+)--arginine ADP-ribosyltransferase 5
Gene namesi
Name:Art5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628834. Art5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 308285Ecto-ADP-ribosyltransferase 5PRO_0000379472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 259By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5XHY4.

Expressioni

Gene expression databases

GenevisibleiQ5XHY4. RN.

Structurei

3D structure databases

ProteinModelPortaliQ5XHY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVE0. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
InParanoidiQ5XHY4.
KOiK19977.
OMAiLHFEPKR.
OrthoDBiEOG7D85WV.
PhylomeDBiQ5XHY4.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XHY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILEDLLMVL SCLALHILWK VQAVPILPLS LVPDTFDDAY VGCSEEMEEK
60 70 80 90 100
AGLLLKEEMA RHALLRESWE AAQEAWAHGR HKLTLPPGFK AQHGVAVMVY
110 120 130 140 150
TNSSNTLYWE LNQAVRTGGR SRELYMRHFP FKALHFYLTR ALQLLRGTGG
160 170 180 190 200
CSREAGEVVF RGVSSLHFEP KRLGDSVRLG QFASSSVDER VARRFGNATF
210 220 230 240 250
FNLRTCFGAP IQALSVFPEE REVLIPPHEV FLVTGFSQDG AQSIVTLWSY
260 270 280 290 300
NQTCSHFNCA YLGGEKRRGC VSSRAGQPES FSTEALALQS GKTLLLAPGE

LQLSRAGP
Length:308
Mass (Da):34,201
Last modified:November 23, 2004 - v1
Checksum:i45B0063435437D2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083915 mRNA. Translation: AAH83915.1.
RefSeqiNP_001013057.1. NM_001013039.1.
UniGeneiRn.19845.

Genome annotation databases

EnsembliENSRNOT00000055243; ENSRNOP00000052118; ENSRNOG00000020242.
GeneIDi259167.
KEGGirno:259167.
UCSCiRGD:628834. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083915 mRNA. Translation: AAH83915.1.
RefSeqiNP_001013057.1. NM_001013039.1.
UniGeneiRn.19845.

3D structure databases

ProteinModelPortaliQ5XHY4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ5XHY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055243; ENSRNOP00000052118; ENSRNOG00000020242.
GeneIDi259167.
KEGGirno:259167.
UCSCiRGD:628834. rat.

Organism-specific databases

CTDi116969.
RGDi628834. Art5.

Phylogenomic databases

eggNOGiENOG410IVE0. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
InParanoidiQ5XHY4.
KOiK19977.
OMAiLHFEPKR.
OrthoDBiEOG7D85WV.
PhylomeDBiQ5XHY4.

Miscellaneous databases

NextBioi624214.
PROiQ5XHY4.

Gene expression databases

GenevisibleiQ5XHY4. RN.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiNAR5_RAT
AccessioniPrimary (citable) accession number: Q5XHY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.