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Protein

Tesmin

Gene

Mtl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in spermatogenesis.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tesmin
Alternative name(s):
Metallothionein-like 5, testis-specific
Gene namesi
Name:Mtl5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309788. Mtl5.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475TesminPRO_0000349273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphoserineCombined sources
Modified residuei67 – 671PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XHX9.
PRIDEiQ5XHX9.

PTM databases

iPTMnetiQ5XHX9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019861.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini263 – 372110CRCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lin-54 family.Curated
Contains 1 CRC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1171. Eukaryota.
ENOG4110UR5. LUCA.
GeneTreeiENSGT00390000013974.
HOGENOMiHOG000082453.
HOVERGENiHBG108153.
InParanoidiQ5XHX9.
OMAiHHLSPTK.
OrthoDBiEOG7DFXBK.
PhylomeDBiQ5XHX9.
TreeFamiTF313189.

Family and domain databases

InterProiIPR005172. CRC.
IPR028307. Lin-54_fam.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR12446. PTHR12446. 1 hit.
PfamiPF03638. TCR. 1 hit.
[Graphical view]
SMARTiSM01114. CXC. 1 hit.
[Graphical view]
PROSITEiPS51634. CRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XHX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDALLGAMT GPEDELGAEL FGSERAFADG LALSPAGGAA DRDELPVLAD
60 70 80 90 100
AYLGATEPGE PLLRALSPPP GAEVPAALLG DFPGLPELRS SDDAAPPPAY
110 120 130 140 150
SVHVLSSLLP GARGPALLPL SAGVRVIPVE IKEAGGGVPG SSPEDAAFQA
160 170 180 190 200
PLAQESCCKF SSSQEAEEAS GCPRKKDSSP MVICQLKGGA QMLCIDNCGA
210 220 230 240 250
RELKALHLLP QYDDQSSFPQ SELPKPMTTL VGRLLPVPAK LNLITQVDNG
260 270 280 290 300
ALPSAVNGAA FPSGPALQGP PKIALAGYCD CFSSGDFCNS CSCNNLRHEL
310 320 330 340 350
ERFKAIKACL DRNPEAFQPK MGKGRLGAAK LRHSKGCNCK RSGCLKNYCE
360 370 380 390 400
CYEAKITCSS ICKCIACKNY EESPERKMLM STPHYMEPGD FESSHHLSPA
410 420 430 440 450
KFSGPPRLRK NRQAFSCISW EVVEATCACL LAQGEEAEQE RCSPSLAEQM
460 470
VLEEFGRCLS QILHIEFKSK GLKIE
Length:475
Mass (Da):50,469
Last modified:September 2, 2008 - v2
Checksum:iFBB0DFBB345DA6A8
GO

Sequence cautioni

The sequence AAH83920.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083920 mRNA. Translation: AAH83920.1. Different initiation.
RefSeqiNP_001012069.2. NM_001012069.2.
UniGeneiRn.105169.

Genome annotation databases

EnsembliENSRNOT00000019861; ENSRNOP00000019861; ENSRNOG00000014671.
GeneIDi309142.
KEGGirno:309142.
UCSCiRGD:1309788. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083920 mRNA. Translation: AAH83920.1. Different initiation.
RefSeqiNP_001012069.2. NM_001012069.2.
UniGeneiRn.105169.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019861.

PTM databases

iPTMnetiQ5XHX9.

Proteomic databases

PaxDbiQ5XHX9.
PRIDEiQ5XHX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019861; ENSRNOP00000019861; ENSRNOG00000014671.
GeneIDi309142.
KEGGirno:309142.
UCSCiRGD:1309788. rat.

Organism-specific databases

CTDi9633.
RGDi1309788. Mtl5.

Phylogenomic databases

eggNOGiKOG1171. Eukaryota.
ENOG4110UR5. LUCA.
GeneTreeiENSGT00390000013974.
HOGENOMiHOG000082453.
HOVERGENiHBG108153.
InParanoidiQ5XHX9.
OMAiHHLSPTK.
OrthoDBiEOG7DFXBK.
PhylomeDBiQ5XHX9.
TreeFamiTF313189.

Miscellaneous databases

NextBioi660236.
PROiQ5XHX9.

Family and domain databases

InterProiIPR005172. CRC.
IPR028307. Lin-54_fam.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR12446. PTHR12446. 1 hit.
PfamiPF03638. TCR. 1 hit.
[Graphical view]
SMARTiSM01114. CXC. 1 hit.
[Graphical view]
PROSITEiPS51634. CRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34 AND SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMTL5_RAT
AccessioniPrimary (citable) accession number: Q5XHX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 11, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.