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Protein

Taperin

Gene

Tprn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Taperin
Gene namesi
Name:Tprn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1562935. Tprn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753TaperinPRO_0000330311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741PhosphoserineCombined sources
Modified residuei458 – 4581PhosphoserineCombined sources
Modified residuei502 – 5021PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XHX2.
PRIDEiQ5XHX2.

PTM databases

PhosphoSiteiQ5XHX2.

Expressioni

Gene expression databases

GenevisibleiQ5XHX2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014489.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi106 – 321216Pro-richAdd
BLAST
Compositional biasi638 – 66932Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the taperin family.Curated

Phylogenomic databases

eggNOGiENOG410IHYC. Eukaryota.
ENOG410ZR6R. LUCA.
GeneTreeiENSGT00530000064035.
HOVERGENiHBG107679.
InParanoidiQ5XHX2.
OMAiRMPAWKR.
OrthoDBiEOG72G18V.
PhylomeDBiQ5XHX2.
TreeFamiTF333324.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
IPR033359. TPRN.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PTHR21685:SF1. PTHR21685:SF1. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XHX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLGRLDPG PRTVMPAWKR EILERRRAKL AALSGGPGSG AAPDGPNERL
60 70 80 90 100
VLAESLGPLS QNPFMRLESE RRRGARPAQQ LLELYCRVPG VRTIRADNIL
110 120 130 140 150
IIESAPGFPP AVPPASSIRA AEVVVYEEPQ PGRVSRLLEK FDSPAAPRRR
160 170 180 190 200
GSPERFRPAL PQLPVAPASA ATRAPTNRSL APAPPVLPSQ PAPPISPVPV
210 220 230 240 250
AQRAGQRSAC CEPAHPDGTA GPGARRSDFL QKTGSNSFTV HPRGLPGSAV
260 270 280 290 300
NRSLSNGPMT QESPAGPANG LSGSPPVPGK WKPKVESKEP SLHPPPSPGT
310 320 330 340 350
PSATPVGPPA FLAPSPASAT PSQRQWVSSA TSANDSFEIR PSSKPDMETI
360 370 380 390 400
PIGDLQARAL ANLRVNSRNS FVLIPKRKAP GNYPSAAGRQ FEEPKGEVGW
410 420 430 440 450
ASQSQGLGSQ LVSTVDGAPA LEKSSLAAEM QWAVREGGCP RPAISDTDKS
460 470 480 490 500
VRRQRPASPP PFLPATTEAE PAEGLGVPGL TKNGQEPVRP GLPVTFIDEV
510 520 530 540 550
DSEEAAFQEA KLPSSAVGVP SQYHLHPSTP GHTSELLNRG SNTFTVVPKR
560 570 580 590 600
KPGTLQEPHL SQTNGQFQQG AEEQDADSLS GPHTTLENAL KKRYPTVNEI
610 620 630 640 650
EVIGGYLALQ KSCLIKAGSS RKKMKISFND KSLHTTFEYP SESSLAQEEA
660 670 680 690 700
EEEEEEEEEE EGEDGEEEEV GPDSEKSFTV LLPRATFVSS VGPESSSGLS
710 720 730 740 750
SYTPKHSMAF SKWQEQTLVQ APTEVELPPK EVMLTPASQN DLSDFRSEPA

LYF
Length:753
Mass (Da):80,272
Last modified:April 29, 2008 - v2
Checksum:i9E754FCBA2FB582A
GO

Sequence cautioni

The sequence AAH83928.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03024111 Genomic DNA. No translation available.
BC083928 mRNA. Translation: AAH83928.1. Different initiation.
RefSeqiNP_001019480.2. NM_001024309.2.
UniGeneiRn.116819.

Genome annotation databases

EnsembliENSRNOT00000014489; ENSRNOP00000014489; ENSRNOG00000010896.
GeneIDi499749.
KEGGirno:499749.
UCSCiRGD:1562935. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03024111 Genomic DNA. No translation available.
BC083928 mRNA. Translation: AAH83928.1. Different initiation.
RefSeqiNP_001019480.2. NM_001024309.2.
UniGeneiRn.116819.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014489.

PTM databases

PhosphoSiteiQ5XHX2.

Proteomic databases

PaxDbiQ5XHX2.
PRIDEiQ5XHX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014489; ENSRNOP00000014489; ENSRNOG00000010896.
GeneIDi499749.
KEGGirno:499749.
UCSCiRGD:1562935. rat.

Organism-specific databases

CTDi286262.
RGDi1562935. Tprn.

Phylogenomic databases

eggNOGiENOG410IHYC. Eukaryota.
ENOG410ZR6R. LUCA.
GeneTreeiENSGT00530000064035.
HOVERGENiHBG107679.
InParanoidiQ5XHX2.
OMAiRMPAWKR.
OrthoDBiEOG72G18V.
PhylomeDBiQ5XHX2.
TreeFamiTF333324.

Miscellaneous databases

NextBioi703870.
PROiQ5XHX2.

Gene expression databases

GenevisibleiQ5XHX2. RN.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
IPR033359. TPRN.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PTHR21685:SF1. PTHR21685:SF1. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-753.
    Tissue: Testis.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274 AND SER-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTPRN_RAT
AccessioniPrimary (citable) accession number: Q5XHX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 11, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.