Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hormonally up-regulated neu tumor-associated kinase homolog A

Gene

hunk-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841ATPPROSITE-ProRule annotationBy similarity
Active sitei179 – 1791Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 699ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hormonally up-regulated neu tumor-associated kinase homolog A (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase MAK-V A
Short name:
xMAK-V A
Gene namesi
Name:hunk-a
Synonyms:makv-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-968421. hunk.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Hormonally up-regulated neu tumor-associated kinase homolog APRO_0000347328Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5XHI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 313259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG006086.
KOiK08797.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XHI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAAAGDGLS ESPSRFLAGE KPPVHLEETF LPACISNVSR ETLRNFQHTK
60 70 80 90 100
RVGSYLIGRK LGEGSFAKVR EGLHVVTGEK VAIKVIDKKK AKKDTYVTKN
110 120 130 140 150
LRREGQIQQM IRHPNITQLL DILETENSYY LVMELCPGGN LMHKIYEKKR
160 170 180 190 200
LEEHEARKYI RQLILAVEHL HRAGVVHRDL KIENLLLDEN NNIKLIDFGL
210 220 230 240 250
SNCAGILGYS DPFSTQCGSP AYAAPELLAR KKYGPKVDVW SIGVNMYAML
260 270 280 290 300
TGTLPFTVEP FSLRALYQKM VDKDMNPLPT HLSPAAISFL RSLLEPDPLK
310 320 330 340 350
RPNIQQALAN RWLNDNYHGK GLHTYPNRIH LEDLSQSVVL HMSEKLGYKH
360 370 380 390 400
SDVINVILSN RACHTLAVYF LLNRKLEHYL VNMRKPDIND NVCHKNQFHQ
410 420 430 440 450
LEKYKMNKNS YEERRSKDLE KRGEPQQRPI QRKLDKCSPS HRQNACLTPQ
460 470 480 490 500
GHSNKGPVKE RRSSKSERES FGGLSPFHEV RITKTGCMTS CSLEYLEMQS
510 520 530 540 550
PDPRTPKIMR RQDSHSQETV NVNMGSRIRE THLNVVRSFE SVNREDQIES
560 570 580 590 600
LSPNHQYRVI GSPVSFSPRH SSERTLSPIF QFDNTSPSKS HFNQASFTYD
610 620 630 640 650
DKSSPSSPES MSPTSPHSPS CNNNISGNLG SPNCVRSRGR FPMMGIGQML
660 670 680 690
RKRNQVVSPK GEKPLETRMP PLHQMSPGYA SFNSSDMNGF C
Length:691
Mass (Da):78,489
Last modified:November 23, 2004 - v1
Checksum:iC143FDD2974A3798
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791P → A in AAQ85059 (PubMed:14740210).Curated
Sequence conflicti286 – 2861A → G in AAQ85059 (PubMed:14740210).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY318877 mRNA. Translation: AAQ85059.1.
BC084068 mRNA. Translation: AAH84068.1.
RefSeqiNP_001084712.1. NM_001091243.1.
UniGeneiXl.24322.

Genome annotation databases

GeneIDi414676.
KEGGixla:414676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY318877 mRNA. Translation: AAQ85059.1.
BC084068 mRNA. Translation: AAH84068.1.
RefSeqiNP_001084712.1. NM_001091243.1.
UniGeneiXl.24322.

3D structure databases

ProteinModelPortaliQ5XHI9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414676.
KEGGixla:414676.

Organism-specific databases

CTDi30811.
XenbaseiXB-GENE-968421. hunk.

Phylogenomic databases

HOVERGENiHBG006086.
KOiK08797.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and developmental expression of MARK/Par-1/MELK-related protein kinase xMAK-V in Xenopus laevis."
    Ruzov A.S., Mertsalov I.B., Meehan R., Kiselev S.L., Buchman V.L., Korobko I.V.
    Dev. Genes Evol. 214:139-143(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: GastrulaImported.

Entry informationi

Entry nameiHUNKA_XENLA
AccessioniPrimary (citable) accession number: Q5XHI9
Secondary accession number(s): Q6VZ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.